Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36127 http://dx.doi.org/10.3390/nu5041276 |
Resumo: | We hypothesize that improvements in the gut microbiota are capable of ameliorating gut permeability and, consequently, reducing systemic inflammation and the risk of frailty. This study aims to evaluate some effects of synbiotic supplementation on inflammatory markers and the body composition of the elderly at risk of frailty. in a double-blind study that lasted three months, 17 elderly individuals fulfilling one frailty criteria (grip strength) were randomly distributed into two groups: SYN (n = 9), daily intake of synbiotic (6 g Frutooligossacarides, 10(8) to 10(9) CFU Lactobacillus paracasei, 10(8) to 10(9) CFU Lactobacillus rhamnosus, 10(8) to 10(9) CFU Lactobacillus acidophilus and 10(8) to 10(9) CFU Bifidobacterium lactis), or placebo (maltodextrin; PLA; n = 8). Subjects were analyzed for anthropometric measurements, bioelectric impedance with vectorial analysis (BIVA), IL-6 and TNF-alpha. A comparison between groups did not show any difference for the variables investigated. in turn, individual analysis of electrical impedance (BIVA) demonstrated that the majority of SYN individuals maintained or improved their tissue hydration, when compared to the PLA group after supplementation. in conclusion, three months of synbiotic supplementation did not promote any significant changes in inflammatory cytokines or body composition, but demonstrated a trend towards a preservation of hydration status in apparently healthy elderly individuals. |
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Valentini Neto, JoaoMelo, Camila Maria de [UNIFESP]Lima Ribeiro, Sandra MariaUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:31:28Z2016-01-24T14:31:28Z2013-04-01Nutrients. Basel: Mdpi Ag, v. 5, n. 4, p. 1276-1286, 2013.2072-6643http://repositorio.unifesp.br/handle/11600/36127http://dx.doi.org/10.3390/nu5041276WOS000318019300015.pdf10.3390/nu5041276WOS:000318019300015We hypothesize that improvements in the gut microbiota are capable of ameliorating gut permeability and, consequently, reducing systemic inflammation and the risk of frailty. This study aims to evaluate some effects of synbiotic supplementation on inflammatory markers and the body composition of the elderly at risk of frailty. in a double-blind study that lasted three months, 17 elderly individuals fulfilling one frailty criteria (grip strength) were randomly distributed into two groups: SYN (n = 9), daily intake of synbiotic (6 g Frutooligossacarides, 10(8) to 10(9) CFU Lactobacillus paracasei, 10(8) to 10(9) CFU Lactobacillus rhamnosus, 10(8) to 10(9) CFU Lactobacillus acidophilus and 10(8) to 10(9) CFU Bifidobacterium lactis), or placebo (maltodextrin; PLA; n = 8). Subjects were analyzed for anthropometric measurements, bioelectric impedance with vectorial analysis (BIVA), IL-6 and TNF-alpha. A comparison between groups did not show any difference for the variables investigated. in turn, individual analysis of electrical impedance (BIVA) demonstrated that the majority of SYN individuals maintained or improved their tissue hydration, when compared to the PLA group after supplementation. in conclusion, three months of synbiotic supplementation did not promote any significant changes in inflammatory cytokines or body composition, but demonstrated a trend towards a preservation of hydration status in apparently healthy elderly individuals.Univ São Paulo, Sch Arts Sci & Humanities, BR-03828000 São Paulo, BrazilUniversidade Federal de São Paulo, BR-04020050 São Paulo, BrazilUniversidade Federal de São Paulo, EPM, BR-04020050 São Paulo, BrazilWeb of Science1276-1286engMdpi AgNutrientssymbioticaginginflammationBIVAbody compositionEffects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318019300015.pdfapplication/pdf447997${dspace.ui.url}/bitstream/11600/36127/1/WOS000318019300015.pdf81093daffb46e039f862582342aeb063MD51open accessTEXTWOS000318019300015.pdf.txtWOS000318019300015.pdf.txtExtracted texttext/plain29013${dspace.ui.url}/bitstream/11600/36127/2/WOS000318019300015.pdf.txt39696e47a381b9b0f1e2b8233aeb66d2MD52open access11600/361272022-07-08 10:33:23.833open accessoai:repositorio.unifesp.br:11600/36127Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-07-08T13:33:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
title |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
spellingShingle |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study Valentini Neto, Joao symbiotic aging inflammation BIVA body composition |
title_short |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
title_full |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
title_fullStr |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
title_full_unstemmed |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
title_sort |
Effects of Three-Month Intake of Synbiotic on Inflammation and Body Composition in the Elderly: A Pilot Study |
author |
Valentini Neto, Joao |
author_facet |
Valentini Neto, Joao Melo, Camila Maria de [UNIFESP] Lima Ribeiro, Sandra Maria |
author_role |
author |
author2 |
Melo, Camila Maria de [UNIFESP] Lima Ribeiro, Sandra Maria |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Valentini Neto, Joao Melo, Camila Maria de [UNIFESP] Lima Ribeiro, Sandra Maria |
dc.subject.eng.fl_str_mv |
symbiotic aging inflammation BIVA body composition |
topic |
symbiotic aging inflammation BIVA body composition |
description |
We hypothesize that improvements in the gut microbiota are capable of ameliorating gut permeability and, consequently, reducing systemic inflammation and the risk of frailty. This study aims to evaluate some effects of synbiotic supplementation on inflammatory markers and the body composition of the elderly at risk of frailty. in a double-blind study that lasted three months, 17 elderly individuals fulfilling one frailty criteria (grip strength) were randomly distributed into two groups: SYN (n = 9), daily intake of synbiotic (6 g Frutooligossacarides, 10(8) to 10(9) CFU Lactobacillus paracasei, 10(8) to 10(9) CFU Lactobacillus rhamnosus, 10(8) to 10(9) CFU Lactobacillus acidophilus and 10(8) to 10(9) CFU Bifidobacterium lactis), or placebo (maltodextrin; PLA; n = 8). Subjects were analyzed for anthropometric measurements, bioelectric impedance with vectorial analysis (BIVA), IL-6 and TNF-alpha. A comparison between groups did not show any difference for the variables investigated. in turn, individual analysis of electrical impedance (BIVA) demonstrated that the majority of SYN individuals maintained or improved their tissue hydration, when compared to the PLA group after supplementation. in conclusion, three months of synbiotic supplementation did not promote any significant changes in inflammatory cytokines or body composition, but demonstrated a trend towards a preservation of hydration status in apparently healthy elderly individuals. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-04-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:28Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:28Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Nutrients. Basel: Mdpi Ag, v. 5, n. 4, p. 1276-1286, 2013. |
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http://repositorio.unifesp.br/handle/11600/36127 http://dx.doi.org/10.3390/nu5041276 |
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2072-6643 |
dc.identifier.file.none.fl_str_mv |
WOS000318019300015.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3390/nu5041276 |
dc.identifier.wos.none.fl_str_mv |
WOS:000318019300015 |
identifier_str_mv |
Nutrients. Basel: Mdpi Ag, v. 5, n. 4, p. 1276-1286, 2013. 2072-6643 WOS000318019300015.pdf 10.3390/nu5041276 WOS:000318019300015 |
url |
http://repositorio.unifesp.br/handle/11600/36127 http://dx.doi.org/10.3390/nu5041276 |
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eng |
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1276-1286 |
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Mdpi Ag |
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Mdpi Ag |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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