Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/51400 http://dx.doi.org/10.1371/journal.pone.0182287 |
Resumo: | Purpose Primary Sjogren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjogren's syndrome. This study aimed to determine the value of salivary gland ultrasonography in the diagnosis and prognosis of Sjogren's syndrome by relating ultrasonography severity scores to clinical and laboratory data. Methods Seventy patients who fulfilled the 2002 American-European Consensus Group diagnostic criteria for primary Sjogren's syndrome were selected from 84 patients receiving care in specialized outpatient clinics at our institution from November 2013 to May 2016. Their serology, European League Against Rheumatism Sjogren's syndrome disease activity index (ESSDAI), salivary flow rate, immunoglobulin G, and salivary and serum beta-2 microglobulin levels were measured. Salivary gland ultrasonography was performed by an experienced radiologist, using scores of 1-4 to classify salivary gland impairment. Results Salivary gland ultrasonography scores of 1 or 2 were associated with an ESSDAI <5. Ultrasonography scores of 3 or 4 were associated with an ESSDAI >= 5 (p = 0.064), a positive antinuclear antibody test (p = 0.006), positive anti-Ro/SSA antibodies (p = 0.003), positive anti-La/SSB antibodies (p = 0.077), positive rheumatoid factor (p = 0.034), and immunoglobulin G levels >1600 mg/dL (p = 0.077). Salivary flow rate was lower in patients with scores 3 or 4 (p = 0.001). Conclusion This study provides further evidence that salivary gland ultrasonography can be used not only for diagnosis but also for prognostic evaluation of primary Sjogren's syndrome. These findings confirm what has been reported in the literature. However, further analyses involving larger matched samples are required to support this finding and include salivary gland ultrasonography as part of the diagnostic criteria for Sjogren's syndrome. |
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Fidelix, Tania [UNIFESP]Czapkowski, Adriano [UNIFESP]Azjen, Sergio [UNIFESP]Andriolo, Adagmar [UNIFESP]Trevisani, Virginia F. M. [UNIFESP]2019-08-19T11:49:46Z2019-08-19T11:49:46Z2017Plos One. San Francisco, v. 12, n. 8, p. -, 2017.1932-6203http://repositorio.unifesp.br/handle/11600/51400http://dx.doi.org/10.1371/journal.pone.0182287WOS000406944300026.pdf10.1371/journal.pone.0182287WOS:000406944300026Purpose Primary Sjogren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjogren's syndrome. This study aimed to determine the value of salivary gland ultrasonography in the diagnosis and prognosis of Sjogren's syndrome by relating ultrasonography severity scores to clinical and laboratory data. Methods Seventy patients who fulfilled the 2002 American-European Consensus Group diagnostic criteria for primary Sjogren's syndrome were selected from 84 patients receiving care in specialized outpatient clinics at our institution from November 2013 to May 2016. Their serology, European League Against Rheumatism Sjogren's syndrome disease activity index (ESSDAI), salivary flow rate, immunoglobulin G, and salivary and serum beta-2 microglobulin levels were measured. Salivary gland ultrasonography was performed by an experienced radiologist, using scores of 1-4 to classify salivary gland impairment. Results Salivary gland ultrasonography scores of 1 or 2 were associated with an ESSDAI <5. Ultrasonography scores of 3 or 4 were associated with an ESSDAI >= 5 (p = 0.064), a positive antinuclear antibody test (p = 0.006), positive anti-Ro/SSA antibodies (p = 0.003), positive anti-La/SSB antibodies (p = 0.077), positive rheumatoid factor (p = 0.034), and immunoglobulin G levels >1600 mg/dL (p = 0.077). Salivary flow rate was lower in patients with scores 3 or 4 (p = 0.001). Conclusion This study provides further evidence that salivary gland ultrasonography can be used not only for diagnosis but also for prognostic evaluation of primary Sjogren's syndrome. These findings confirm what has been reported in the literature. However, further analyses involving larger matched samples are required to support this finding and include salivary gland ultrasonography as part of the diagnostic criteria for Sjogren's syndrome.Univ Fed São Paulo UNIFESP, Dept Evidence Based Med, São Paulo, SP, BrazilUniv Fed São Paulo, Dept Radiol, São Paulo, SP, BrazilUniv Fed São Paulo, Dept Lab Med, São Paulo, SP, BrazilUniv Fed São Paulo UNIFESP, Dept Evidence Based Med, São Paulo, SP, BrazilUniv Fed São Paulo, Dept Radiol, São Paulo, SP, BrazilUniv Fed São Paulo, Dept Lab Med, São Paulo, SP, BrazilWeb of Science-engPublic Library ScienceSalivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000406944300026.pdfapplication/pdf1055382${dspace.ui.url}/bitstream/11600/51400/1/WOS000406944300026.pdf4cc64cc78f8e8b9cda704d022b96a6baMD51open accessTEXTWOS000406944300026.pdf.txtWOS000406944300026.pdf.txtExtracted texttext/plain39177${dspace.ui.url}/bitstream/11600/51400/2/WOS000406944300026.pdf.txt8c67172763c57f304d0c0906987febcaMD52open accessTHUMBNAILWOS000406944300026.pdf.jpgWOS000406944300026.pdf.jpgIM Thumbnailimage/jpeg7586${dspace.ui.url}/bitstream/11600/51400/4/WOS000406944300026.pdf.jpg8fead85710b9dd5b9d7a334a9ccc1f10MD54open access11600/514002022-08-01 18:20:09.381open accessoai:repositorio.unifesp.br:11600/51400Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T21:20:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
title |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
spellingShingle |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome Fidelix, Tania [UNIFESP] |
title_short |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
title_full |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
title_fullStr |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
title_full_unstemmed |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
title_sort |
Salivary gland ultrasonography as a predictor of clinical activity in Sjogren's syndrome |
author |
Fidelix, Tania [UNIFESP] |
author_facet |
Fidelix, Tania [UNIFESP] Czapkowski, Adriano [UNIFESP] Azjen, Sergio [UNIFESP] Andriolo, Adagmar [UNIFESP] Trevisani, Virginia F. M. [UNIFESP] |
author_role |
author |
author2 |
Czapkowski, Adriano [UNIFESP] Azjen, Sergio [UNIFESP] Andriolo, Adagmar [UNIFESP] Trevisani, Virginia F. M. [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fidelix, Tania [UNIFESP] Czapkowski, Adriano [UNIFESP] Azjen, Sergio [UNIFESP] Andriolo, Adagmar [UNIFESP] Trevisani, Virginia F. M. [UNIFESP] |
description |
Purpose Primary Sjogren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjogren's syndrome. This study aimed to determine the value of salivary gland ultrasonography in the diagnosis and prognosis of Sjogren's syndrome by relating ultrasonography severity scores to clinical and laboratory data. Methods Seventy patients who fulfilled the 2002 American-European Consensus Group diagnostic criteria for primary Sjogren's syndrome were selected from 84 patients receiving care in specialized outpatient clinics at our institution from November 2013 to May 2016. Their serology, European League Against Rheumatism Sjogren's syndrome disease activity index (ESSDAI), salivary flow rate, immunoglobulin G, and salivary and serum beta-2 microglobulin levels were measured. Salivary gland ultrasonography was performed by an experienced radiologist, using scores of 1-4 to classify salivary gland impairment. Results Salivary gland ultrasonography scores of 1 or 2 were associated with an ESSDAI <5. Ultrasonography scores of 3 or 4 were associated with an ESSDAI >= 5 (p = 0.064), a positive antinuclear antibody test (p = 0.006), positive anti-Ro/SSA antibodies (p = 0.003), positive anti-La/SSB antibodies (p = 0.077), positive rheumatoid factor (p = 0.034), and immunoglobulin G levels >1600 mg/dL (p = 0.077). Salivary flow rate was lower in patients with scores 3 or 4 (p = 0.001). Conclusion This study provides further evidence that salivary gland ultrasonography can be used not only for diagnosis but also for prognostic evaluation of primary Sjogren's syndrome. These findings confirm what has been reported in the literature. However, further analyses involving larger matched samples are required to support this finding and include salivary gland ultrasonography as part of the diagnostic criteria for Sjogren's syndrome. |
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2017 |
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2017 |
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Plos One. San Francisco, v. 12, n. 8, p. -, 2017. |
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http://repositorio.unifesp.br/handle/11600/51400 http://dx.doi.org/10.1371/journal.pone.0182287 |
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1932-6203 |
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