OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | https://dx.doi.org/10.1016/j.fertnstert.2010.02.036 https://repositorio.unifesp.br/handle/11600/33004 |
Resumo: | To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). the expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.) |
| id |
UFSP_0f8acdead264a990b14dd001f9738e7a |
|---|---|
| oai_identifier_str |
oai:repositorio.unifesp.br/:11600/33004 |
| network_acronym_str |
UFSP |
| network_name_str |
Repositório Institucional da UNIFESP |
| repository_id_str |
3465 |
| spelling |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndromeTurner syndromeGonadal dysgenesisOCT4 geneSRY geneTSPY geneY-chromosomeTo show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). the expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.)Universidade Federal de São Paulo, Dept Med, Div Endocrinol, São Paulo, BrazilABC Sch Med, Dept Gynecol & Obstet, Div Gynecol Pathol & Human Reprod, Santo Andre, BrazilUniversidade Federal de São Paulo, Dept Med, Div Endocrinol, São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)ABC Sch MedBianco, Bianca Alves Vieira [UNIFESP]Oliveira, Kelly Cristina de [UNIFESP]Guedes, Alexis Dourado [UNIFESP]Barbosa, Caio ParenteLipay, Monica Vannucci Nunes [UNIFESP]Verreschi, Ieda Therezinha do Nascimento [UNIFESP]2016-01-24T14:05:35Z2016-01-24T14:05:35Z2010-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2347-2349https://dx.doi.org/10.1016/j.fertnstert.2010.02.036Fertility and Sterility. New York: Elsevier B.V., v. 94, n. 6, p. 2347-2349, 2010.10.1016/j.fertnstert.2010.02.0360015-0282https://repositorio.unifesp.br/handle/11600/33004WOS:000283441400090engFertility and Sterilityinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-07-31T19:19:54Zoai:repositorio.unifesp.br/:11600/33004Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-07-31T19:19:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| title |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| spellingShingle |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome Bianco, Bianca Alves Vieira [UNIFESP] Turner syndrome Gonadal dysgenesis OCT4 gene SRY gene TSPY gene Y-chromosome |
| title_short |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| title_full |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| title_fullStr |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| title_full_unstemmed |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| title_sort |
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome |
| author |
Bianco, Bianca Alves Vieira [UNIFESP] |
| author_facet |
Bianco, Bianca Alves Vieira [UNIFESP] Oliveira, Kelly Cristina de [UNIFESP] Guedes, Alexis Dourado [UNIFESP] Barbosa, Caio Parente Lipay, Monica Vannucci Nunes [UNIFESP] Verreschi, Ieda Therezinha do Nascimento [UNIFESP] |
| author_role |
author |
| author2 |
Oliveira, Kelly Cristina de [UNIFESP] Guedes, Alexis Dourado [UNIFESP] Barbosa, Caio Parente Lipay, Monica Vannucci Nunes [UNIFESP] Verreschi, Ieda Therezinha do Nascimento [UNIFESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) ABC Sch Med |
| dc.contributor.author.fl_str_mv |
Bianco, Bianca Alves Vieira [UNIFESP] Oliveira, Kelly Cristina de [UNIFESP] Guedes, Alexis Dourado [UNIFESP] Barbosa, Caio Parente Lipay, Monica Vannucci Nunes [UNIFESP] Verreschi, Ieda Therezinha do Nascimento [UNIFESP] |
| dc.subject.por.fl_str_mv |
Turner syndrome Gonadal dysgenesis OCT4 gene SRY gene TSPY gene Y-chromosome |
| topic |
Turner syndrome Gonadal dysgenesis OCT4 gene SRY gene TSPY gene Y-chromosome |
| description |
To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). the expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.) |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010-11-01 2016-01-24T14:05:35Z 2016-01-24T14:05:35Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://dx.doi.org/10.1016/j.fertnstert.2010.02.036 Fertility and Sterility. New York: Elsevier B.V., v. 94, n. 6, p. 2347-2349, 2010. 10.1016/j.fertnstert.2010.02.036 0015-0282 https://repositorio.unifesp.br/handle/11600/33004 WOS:000283441400090 |
| url |
https://dx.doi.org/10.1016/j.fertnstert.2010.02.036 https://repositorio.unifesp.br/handle/11600/33004 |
| identifier_str_mv |
Fertility and Sterility. New York: Elsevier B.V., v. 94, n. 6, p. 2347-2349, 2010. 10.1016/j.fertnstert.2010.02.036 0015-0282 WOS:000283441400090 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Fertility and Sterility |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| dc.format.none.fl_str_mv |
2347-2349 |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1814268439700701184 |