The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/001300000h7fw |
| DOI: | 10.1590/S1516-44462012000200014 |
| Texto Completo: | http://dx.doi.org/10.1590/S1516-44462012000200014 http://repositorio.unifesp.br/handle/11600/7139 |
Resumo: | OBJECTIVE: To report structural and functional neuroimaging studies exploring the potential role of the orbitofrontal cortex (OFC) in the pathophysiology of the most prevalent psychiatric disorders (PD). METHOD: A non-systematic literature review was conducted by means of MEDLINE using the following terms as parameters: orbitofrontal cortex, schizophrenia, bipolar disorder, major depression, anxiety disorders, personality disorders and drug addiction. The electronic search was done up to July 2011. DISCUSSION: Structural and functional OFC abnormalities have been reported in many PD, namely schizophrenia, mood disorders, anxiety disorders, personality disorders and drug addiction. Structural magnetic resonance imaging studies have reported reduced OFC volume in patients with schizophrenia, mood disorders, PTSD, panic disorder, cluster B personality disorders and drug addiction. Furthermore, functional magnetic resonance imaging studies using cognitive paradigms have shown impaired OFC activity in all PD listed above. CONCLUSION: Neuroimaging studies have observed an important OFC involvement in a number of PD. However, future studies are clearly needed to characterize the specific role of OFC on each PD as well as understanding its role in both normal and pathological behavior, mood regulation and cognitive functioning. |
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The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findingsO envolvimento do cortex orbitofrontal em transtornos psiquiátricos: uma atualização dos achados de neuroimagensorbitofrontal cortexschizophreniamood disordersanxiety disorderspersonality disordersneuroimagingcortex orbitofrontalesquizofreniatranstornos afetivostranstornos ansiosostranstornos de personalidadeaquisição de neuroimagensOBJECTIVE: To report structural and functional neuroimaging studies exploring the potential role of the orbitofrontal cortex (OFC) in the pathophysiology of the most prevalent psychiatric disorders (PD). METHOD: A non-systematic literature review was conducted by means of MEDLINE using the following terms as parameters: orbitofrontal cortex, schizophrenia, bipolar disorder, major depression, anxiety disorders, personality disorders and drug addiction. The electronic search was done up to July 2011. DISCUSSION: Structural and functional OFC abnormalities have been reported in many PD, namely schizophrenia, mood disorders, anxiety disorders, personality disorders and drug addiction. Structural magnetic resonance imaging studies have reported reduced OFC volume in patients with schizophrenia, mood disorders, PTSD, panic disorder, cluster B personality disorders and drug addiction. Furthermore, functional magnetic resonance imaging studies using cognitive paradigms have shown impaired OFC activity in all PD listed above. CONCLUSION: Neuroimaging studies have observed an important OFC involvement in a number of PD. However, future studies are clearly needed to characterize the specific role of OFC on each PD as well as understanding its role in both normal and pathological behavior, mood regulation and cognitive functioning.OBJETIVO: Relatar estudos de neuroimagens estruturais e funcionais explorando o papel potencial do córtex orbitofrontal (COF) na fisiopatologia dos transtornos psiquiátricos (TP) mais prevalentes. MÉTODO: Foi realizada uma revisão não sistemática da literatura no MEDLINE, usando como parâmetros os seguintes termos: córtex orbitofrontal, esquizofrenia, transtorno bipolar, depressão maior, transtornos ansiosos, transtornos de personalidade e dependência a drogas. A pesquisa eletrônica foi feita até julho de 2011. DISCUSSÃO: Foram relatadas anormalidades estruturais e funcionais do COF em muitos TP, particularmente esquizofrenia, transtornos afetivos, transtornos ansiosos, transtornos de personalidade e dependência a drogas. Estudos de aquisição de imagens estruturais por ressonância magnética relataram a redução do volume do COF em pacientes portadores de esquizofrenia, transtornos afetivos, TEPT, transtorno do pânico, transtornos de personalidade do grupo B e dependência a drogas. Além disso, estudos de aquisição de imagens funcionais por ressonância magnética empregando paradigmas cognitivos demonstraram alterações na atividade do COF em todos os TP anteriormente relacionados. CONCLUSÃO: Estudos de neuroimagens observaram um envolvimento importante do COF em vários TP. Entretanto, estudos futuros são claramente necessários para caracterizar o papel específico do COF em cada TP, assim como para a compreensão de seu papel tanto no comportamento normal como no patológico, na regulação do humor e no funcionamento cognitivo.Universidade Federal de São Paulo (UNIFESP) Interdisciplinary Laboratory of NeurosciencesUniversidade Federal da Bahia Affective Disorders CenterInstituto Sinapse de Neurociências ClínicasCentro de Pesquisa e Ensaios Clínicos Sinapse-BairralUNIFESP, Interdisciplinary Laboratory of NeurosciencesSciELOAssociação Brasileira de Psiquiatria - ABPUniversidade Federal de São Paulo (UNIFESP)Universidade Federal da Bahia Affective Disorders CenterInstituto Sinapse de Neurociências ClínicasCentro de Pesquisa e Ensaios Clínicos Sinapse-BairralJackowski, Andrea Parolin [UNIFESP]Araujo Filho, Gerardo Maria de [UNIFESP]Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP]Araújo, Célia Maria de [UNIFESP]Reis, Marília [UNIFESP]Nery, Fabiana [UNIFESP]Batista, Ilza Rosa [UNIFESP]Silva, Ivaldo da [UNIFESP]Lacerda, Acioly Luiz Tavares de [UNIFESP]2015-06-14T13:44:45Z2015-06-14T13:44:45Z2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion207-212application/pdfhttp://dx.doi.org/10.1590/S1516-44462012000200014JACKOWSKI, Andrea Parolin et al . The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 2, p. 207-212, jun. 201210.1590/S1516-44462012000200014S1516-44462012000200014.pdf1516-4446S1516-44462012000200014http://repositorio.unifesp.br/handle/11600/7139WOS:000305572300014ark:/48912/001300000h7fwengRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T01:32:30Zoai:repositorio.unifesp.br/:11600/7139Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:18:41.399042Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings O envolvimento do cortex orbitofrontal em transtornos psiquiátricos: uma atualização dos achados de neuroimagens |
| title |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| spellingShingle |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings Jackowski, Andrea Parolin [UNIFESP] orbitofrontal cortex schizophrenia mood disorders anxiety disorders personality disorders neuroimaging cortex orbitofrontal esquizofrenia transtornos afetivos transtornos ansiosos transtornos de personalidade aquisição de neuroimagens Jackowski, Andrea Parolin [UNIFESP] orbitofrontal cortex schizophrenia mood disorders anxiety disorders personality disorders neuroimaging cortex orbitofrontal esquizofrenia transtornos afetivos transtornos ansiosos transtornos de personalidade aquisição de neuroimagens |
| title_short |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| title_full |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| title_fullStr |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| title_full_unstemmed |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| title_sort |
The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings |
| author |
Jackowski, Andrea Parolin [UNIFESP] |
| author_facet |
Jackowski, Andrea Parolin [UNIFESP] Jackowski, Andrea Parolin [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araújo, Célia Maria de [UNIFESP] Reis, Marília [UNIFESP] Nery, Fabiana [UNIFESP] Batista, Ilza Rosa [UNIFESP] Silva, Ivaldo da [UNIFESP] Lacerda, Acioly Luiz Tavares de [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araújo, Célia Maria de [UNIFESP] Reis, Marília [UNIFESP] Nery, Fabiana [UNIFESP] Batista, Ilza Rosa [UNIFESP] Silva, Ivaldo da [UNIFESP] Lacerda, Acioly Luiz Tavares de [UNIFESP] |
| author_role |
author |
| author2 |
Araujo Filho, Gerardo Maria de [UNIFESP] Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araújo, Célia Maria de [UNIFESP] Reis, Marília [UNIFESP] Nery, Fabiana [UNIFESP] Batista, Ilza Rosa [UNIFESP] Silva, Ivaldo da [UNIFESP] Lacerda, Acioly Luiz Tavares de [UNIFESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal da Bahia Affective Disorders Center Instituto Sinapse de Neurociências Clínicas Centro de Pesquisa e Ensaios Clínicos Sinapse-Bairral |
| dc.contributor.author.fl_str_mv |
Jackowski, Andrea Parolin [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araújo, Célia Maria de [UNIFESP] Reis, Marília [UNIFESP] Nery, Fabiana [UNIFESP] Batista, Ilza Rosa [UNIFESP] Silva, Ivaldo da [UNIFESP] Lacerda, Acioly Luiz Tavares de [UNIFESP] |
| dc.subject.por.fl_str_mv |
orbitofrontal cortex schizophrenia mood disorders anxiety disorders personality disorders neuroimaging cortex orbitofrontal esquizofrenia transtornos afetivos transtornos ansiosos transtornos de personalidade aquisição de neuroimagens |
| topic |
orbitofrontal cortex schizophrenia mood disorders anxiety disorders personality disorders neuroimaging cortex orbitofrontal esquizofrenia transtornos afetivos transtornos ansiosos transtornos de personalidade aquisição de neuroimagens |
| description |
OBJECTIVE: To report structural and functional neuroimaging studies exploring the potential role of the orbitofrontal cortex (OFC) in the pathophysiology of the most prevalent psychiatric disorders (PD). METHOD: A non-systematic literature review was conducted by means of MEDLINE using the following terms as parameters: orbitofrontal cortex, schizophrenia, bipolar disorder, major depression, anxiety disorders, personality disorders and drug addiction. The electronic search was done up to July 2011. DISCUSSION: Structural and functional OFC abnormalities have been reported in many PD, namely schizophrenia, mood disorders, anxiety disorders, personality disorders and drug addiction. Structural magnetic resonance imaging studies have reported reduced OFC volume in patients with schizophrenia, mood disorders, PTSD, panic disorder, cluster B personality disorders and drug addiction. Furthermore, functional magnetic resonance imaging studies using cognitive paradigms have shown impaired OFC activity in all PD listed above. CONCLUSION: Neuroimaging studies have observed an important OFC involvement in a number of PD. However, future studies are clearly needed to characterize the specific role of OFC on each PD as well as understanding its role in both normal and pathological behavior, mood regulation and cognitive functioning. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-06-01 2015-06-14T13:44:45Z 2015-06-14T13:44:45Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-44462012000200014 JACKOWSKI, Andrea Parolin et al . The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 2, p. 207-212, jun. 2012 10.1590/S1516-44462012000200014 S1516-44462012000200014.pdf 1516-4446 S1516-44462012000200014 http://repositorio.unifesp.br/handle/11600/7139 WOS:000305572300014 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300000h7fw |
| url |
http://dx.doi.org/10.1590/S1516-44462012000200014 http://repositorio.unifesp.br/handle/11600/7139 |
| identifier_str_mv |
JACKOWSKI, Andrea Parolin et al . The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 2, p. 207-212, jun. 2012 10.1590/S1516-44462012000200014 S1516-44462012000200014.pdf 1516-4446 S1516-44462012000200014 WOS:000305572300014 ark:/48912/001300000h7fw |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista Brasileira de Psiquiatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
207-212 application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria - ABP |
| publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria - ABP |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
| _version_ |
1822219216708698112 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S1516-44462012000200014 |