Hepatitis B vaccine - proposal for a standardized assessment of immune response

Detalhes bibliográficos
Autor(a) principal: Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Data de Publicação: 1992
Outros Autores: Silva, Antonio Eduardo Benedito [UNIFESP], Yamamoto, Marico [UNIFESP], Guimaråes, Rubens Xavier [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0036-46651992000200009
http://repositorio.unifesp.br/handle/11600/296
Resumo: The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies
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spelling Hepatitis B vaccine - proposal for a standardized assessment of immune responseVacinação contra Hepatite B - proposta de padronização da avaliação da resposta imunológicaHepatitis BHepatitis B VaccineAnti-HBSAntibodiesThe authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studiesOs autores realizaram estudo comparativo dos diferentes métodos de avaliação da resposta à vacina contra hepatite B. Foram estudados 86 indivíduos, profissionais da área de saúde, que foram submetidos a esquema de vacinação com três doses de vacina plasmática contra hepatite B (H-B-Vax, Merck, Sharp & Dohme), aplicadas por via intramuscular. A avaliação da resposta imunológica à vacina foi realizada três meses após o término do esquema, através tanto de radioimunoensaio como enzimaimunoensaio. Os resultados obtidos demonstraram que a avaliação semi-quantitativa dos anticorpos anti-HBs por enzimaimunoensaio é perfeitamente superponível ao método de referência, que é a determinação quantitativa de anticorpos por radioimunoensaio. Tendo em vista estes achados, os autores propõem uma padronização da avaliação da resposta à vacina, com o objetivo de predizer a ocasião das doses de reforço e tornar os diferentes estudos comparáveis entre siEscola Paulista de MedicinaEscola Paulista de Medicina Gastroenterology LaboratoryUNIFESP, EPM, Gastroenterology LaboratorySciELOInstituto de Medicina TropicalUniversidade Federal de São Paulo (UNIFESP)Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]Silva, Antonio Eduardo Benedito [UNIFESP]Yamamoto, Marico [UNIFESP]Guimaråes, Rubens Xavier [UNIFESP]2015-06-14T13:24:22Z2015-06-14T13:24:22Z1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion137-140application/pdfhttp://dx.doi.org/10.1590/S0036-46651992000200009Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 34, n. 2, p. 137-140, 1992.10.1590/S0036-46651992000200009S0036-46651992000200009.pdf0036-4665S0036-46651992000200009http://repositorio.unifesp.br/handle/11600/296engRevista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T19:57:13Zoai:repositorio.unifesp.br/:11600/296Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T19:57:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Hepatitis B vaccine - proposal for a standardized assessment of immune response
Vacinação contra Hepatite B - proposta de padronização da avaliação da resposta imunológica
title Hepatitis B vaccine - proposal for a standardized assessment of immune response
spellingShingle Hepatitis B vaccine - proposal for a standardized assessment of immune response
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
title_short Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_full Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_fullStr Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_full_unstemmed Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_sort Hepatitis B vaccine - proposal for a standardized assessment of immune response
author Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
author_facet Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Yamamoto, Marico [UNIFESP]
Guimaråes, Rubens Xavier [UNIFESP]
author_role author
author2 Silva, Antonio Eduardo Benedito [UNIFESP]
Yamamoto, Marico [UNIFESP]
Guimaråes, Rubens Xavier [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Yamamoto, Marico [UNIFESP]
Guimaråes, Rubens Xavier [UNIFESP]
dc.subject.por.fl_str_mv Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
topic Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
description The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies
publishDate 1992
dc.date.none.fl_str_mv 1992-04-01
2015-06-14T13:24:22Z
2015-06-14T13:24:22Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0036-46651992000200009
Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 34, n. 2, p. 137-140, 1992.
10.1590/S0036-46651992000200009
S0036-46651992000200009.pdf
0036-4665
S0036-46651992000200009
http://repositorio.unifesp.br/handle/11600/296
url http://dx.doi.org/10.1590/S0036-46651992000200009
http://repositorio.unifesp.br/handle/11600/296
identifier_str_mv Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 34, n. 2, p. 137-140, 1992.
10.1590/S0036-46651992000200009
S0036-46651992000200009.pdf
0036-4665
S0036-46651992000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 137-140
application/pdf
dc.publisher.none.fl_str_mv Instituto de Medicina Tropical
publisher.none.fl_str_mv Instituto de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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