Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease

Detalhes bibliográficos
Autor(a) principal: Bichuetti, Denis Bernardi [UNIFESP]
Data de Publicação: 2013
Outros Autores: Oliveira, Enedina Maria Lobato de [UNIFESP], Souza, Nilton Amorin de, Tintoré, Mar, Gabbai, Alberto Alain [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/0004-282X20130020
http://repositorio.unifesp.br/handle/11600/7734
Resumo: Although neuromyelitis optica (NMO) is known to be a more severe disease than relapsing-remitting multiple sclerosis (RRMS), few studies comparing both conditions in a single center have been done.Methods: Comparison of our previously published cohort of 41 NMO patients with 177 RRMS patients followed in the same center, from 1994 to 2007. Results: Mean age of onset was 32.6 for NMO and 30.2 for RRMS (p=0.2062) with mean disease duration of 7.4 years for NMO and 10.3 years for RRMS. Patients with NMO had a higher annualized relapse rate (1.0 versus 0.8, p=0.0013) and progression index (0.9 versus 0.6, p≪0.0001), with more patients reaching expanded disability status scale (EDSS) 6.0 (39 versus 17%, p=0.0036). The odds ratio for reaching EDSS 6.0 and being deceased due to NMO in comparison to RRMS were, respectively, 3.14 and 12.15. Conclusion: Patients with NMO have a more severe disease than patients with RRMS, including higher risk of dying of a demyelinating disease.
id UFSP_173da34be44f457a999ab76378013afe
oai_identifier_str oai:repositorio.unifesp.br/:11600/7734
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating diseasePacientes com neuromielite óptica apresentam doença mais incapacitante que pacientes com esclerose múltipla, incluindo maior chance de falecerem de uma doença desmielinizanteneuromyelitis opticamultiple sclerosisdemyelinating diseasesrisk factorsneuromielite ópticaesclerose múltipladoenças desmielinizantesfatores de riscoAlthough neuromyelitis optica (NMO) is known to be a more severe disease than relapsing-remitting multiple sclerosis (RRMS), few studies comparing both conditions in a single center have been done.Methods: Comparison of our previously published cohort of 41 NMO patients with 177 RRMS patients followed in the same center, from 1994 to 2007. Results: Mean age of onset was 32.6 for NMO and 30.2 for RRMS (p=0.2062) with mean disease duration of 7.4 years for NMO and 10.3 years for RRMS. Patients with NMO had a higher annualized relapse rate (1.0 versus 0.8, p=0.0013) and progression index (0.9 versus 0.6, p≪0.0001), with more patients reaching expanded disability status scale (EDSS) 6.0 (39 versus 17%, p=0.0036). The odds ratio for reaching EDSS 6.0 and being deceased due to NMO in comparison to RRMS were, respectively, 3.14 and 12.15. Conclusion: Patients with NMO have a more severe disease than patients with RRMS, including higher risk of dying of a demyelinating disease.Embora a neuromielite óptica (NMO) seja reconhecida como mais grave que a esclerose múltipla remitente recorrente (EMRR), existem poucos estudos comparando as duas doenças em um único centro.Métodos: Comparação de nossa coorte publicada de 41 pacientes com NMO com 177 pacientes com EMRR seguidos no mesmo centro, de 1994 a 2007. Resultados: A média de idade inicial foi de 32,6 anos em NMO e 30,2 anos em EMRR (p=0,2062), com tempo médio de doença de 7,4 anos para NMO e 10,3 anos EMRR. Pacientes com NMO apresentaram maior taxa anualizada de surtos (1,0 versus 0,8, p=0,0013) e índice de progressão (0,9 versus 0,6, p≪0,0001), com mais pacientes atingindo EDSS 6,0 (39 versus 17%, p=0,0036). Os riscos relativos de se alcançar 6,0 EDSS e falecer em decorrência de NMO em comparação com EMRR, foram, respectivamente, 3,14 e 12,15. Conclusão: Pacientes com NMO têm uma doença mais grave do que os pacientes com EMRR, incluindo maior risco de morrer de uma doença desmielinizante.Universidade Federal de São Paulo (UNIFESP) Setor de NeuroimunologiaHospital Universitari Vall d?Hebron Center d?Esclerosi Múltiple de Catalunya-CEMcatUNIFESP, Setor de NeuroimunologiaSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Hospital Universitari Vall d?Hebron Center d?Esclerosi Múltiple de Catalunya-CEMcatBichuetti, Denis Bernardi [UNIFESP]Oliveira, Enedina Maria Lobato de [UNIFESP]Souza, Nilton Amorin deTintoré, MarGabbai, Alberto Alain [UNIFESP]2015-06-14T13:45:24Z2015-06-14T13:45:24Z2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion275-279application/pdfhttp://dx.doi.org/10.1590/0004-282X20130020Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 5, p. 275-279, 2013.10.1590/0004-282X20130020S0004-282X2013000500275.pdf0004-282XS0004-282X2013000500275http://repositorio.unifesp.br/handle/11600/7734engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T12:02:16Zoai:repositorio.unifesp.br/:11600/7734Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T12:02:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
Pacientes com neuromielite óptica apresentam doença mais incapacitante que pacientes com esclerose múltipla, incluindo maior chance de falecerem de uma doença desmielinizante
title Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
spellingShingle Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
Bichuetti, Denis Bernardi [UNIFESP]
neuromyelitis optica
multiple sclerosis
demyelinating diseases
risk factors
neuromielite óptica
esclerose múltipla
doenças desmielinizantes
fatores de risco
title_short Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
title_full Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
title_fullStr Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
title_full_unstemmed Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
title_sort Patients with neuromyelitis optica have a more severe disease than patients with relapsingremitting multiple sclerosis, including higher risk of dying of a demyelinating disease
author Bichuetti, Denis Bernardi [UNIFESP]
author_facet Bichuetti, Denis Bernardi [UNIFESP]
Oliveira, Enedina Maria Lobato de [UNIFESP]
Souza, Nilton Amorin de
Tintoré, Mar
Gabbai, Alberto Alain [UNIFESP]
author_role author
author2 Oliveira, Enedina Maria Lobato de [UNIFESP]
Souza, Nilton Amorin de
Tintoré, Mar
Gabbai, Alberto Alain [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hospital Universitari Vall d?Hebron Center d?Esclerosi Múltiple de Catalunya-CEMcat
dc.contributor.author.fl_str_mv Bichuetti, Denis Bernardi [UNIFESP]
Oliveira, Enedina Maria Lobato de [UNIFESP]
Souza, Nilton Amorin de
Tintoré, Mar
Gabbai, Alberto Alain [UNIFESP]
dc.subject.por.fl_str_mv neuromyelitis optica
multiple sclerosis
demyelinating diseases
risk factors
neuromielite óptica
esclerose múltipla
doenças desmielinizantes
fatores de risco
topic neuromyelitis optica
multiple sclerosis
demyelinating diseases
risk factors
neuromielite óptica
esclerose múltipla
doenças desmielinizantes
fatores de risco
description Although neuromyelitis optica (NMO) is known to be a more severe disease than relapsing-remitting multiple sclerosis (RRMS), few studies comparing both conditions in a single center have been done.Methods: Comparison of our previously published cohort of 41 NMO patients with 177 RRMS patients followed in the same center, from 1994 to 2007. Results: Mean age of onset was 32.6 for NMO and 30.2 for RRMS (p=0.2062) with mean disease duration of 7.4 years for NMO and 10.3 years for RRMS. Patients with NMO had a higher annualized relapse rate (1.0 versus 0.8, p=0.0013) and progression index (0.9 versus 0.6, p≪0.0001), with more patients reaching expanded disability status scale (EDSS) 6.0 (39 versus 17%, p=0.0036). The odds ratio for reaching EDSS 6.0 and being deceased due to NMO in comparison to RRMS were, respectively, 3.14 and 12.15. Conclusion: Patients with NMO have a more severe disease than patients with RRMS, including higher risk of dying of a demyelinating disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-01
2015-06-14T13:45:24Z
2015-06-14T13:45:24Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0004-282X20130020
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 5, p. 275-279, 2013.
10.1590/0004-282X20130020
S0004-282X2013000500275.pdf
0004-282X
S0004-282X2013000500275
http://repositorio.unifesp.br/handle/11600/7734
url http://dx.doi.org/10.1590/0004-282X20130020
http://repositorio.unifesp.br/handle/11600/7734
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 5, p. 275-279, 2013.
10.1590/0004-282X20130020
S0004-282X2013000500275.pdf
0004-282X
S0004-282X2013000500275
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 275-279
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268361438134272

Registros relacionados