Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

Detalhes bibliográficos
Autor(a) principal: Silva,Luiz Carlos Ferreira da
Data de Publicação: 2018
Outros Autores: Porto,Gabriela Granja, Andrade,Emanuel Sávio de Souza, Laureano Filho,José Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400354
Resumo: Abstract Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results: The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.
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spelling Demineralized bone matrix and calcium-phosphate cement in bone regeneration in ratsBone MatrixBone RegenerationRats.Abstract Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results: The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400354Acta Cirúrgica Brasileira v.33 n.4 2018reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020180040000007info:eu-repo/semantics/openAccessSilva,Luiz Carlos Ferreira daPorto,Gabriela GranjaAndrade,Emanuel Sávio de SouzaLaureano Filho,José Rodrigueseng2018-05-10T00:00:00Zoai:scielo:S0102-86502018000400354Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2018-05-10T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
title Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
spellingShingle Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
Silva,Luiz Carlos Ferreira da
Bone Matrix
Bone Regeneration
Rats.
title_short Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
title_full Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
title_fullStr Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
title_full_unstemmed Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
title_sort Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats
author Silva,Luiz Carlos Ferreira da
author_facet Silva,Luiz Carlos Ferreira da
Porto,Gabriela Granja
Andrade,Emanuel Sávio de Souza
Laureano Filho,José Rodrigues
author_role author
author2 Porto,Gabriela Granja
Andrade,Emanuel Sávio de Souza
Laureano Filho,José Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Luiz Carlos Ferreira da
Porto,Gabriela Granja
Andrade,Emanuel Sávio de Souza
Laureano Filho,José Rodrigues
dc.subject.por.fl_str_mv Bone Matrix
Bone Regeneration
Rats.
topic Bone Matrix
Bone Regeneration
Rats.
description Abstract Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results: The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400354
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000400354
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020180040000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.33 n.4 2018
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
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institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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