Schizophrenia and chromosome 6p

• Autor(a) principal: Turecki, Gustavo
• Data de Publicação: 1997
• Outros Autores: Rouleau, Guy A., Joober, Ridha, Mari, Jair de Jesus [UNIFESP], Morgan, Kenneth
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1002/(SICI)1096-8628(19970418)74:2<195; http://repositorio.unifesp.br/handle/11600/25715
• topic: psychiatric disorder; linkage analysis; meta-analysis

Several studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia, Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested, Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies mere selected for the analysis using defined criteria, Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. in addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results, These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia, (C) 1997 Wiley-Lies, Inc.