Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

• Autor(a) principal: Oliveira, José Salvador Rodrigues de [UNIFESP]
• Data de Publicação: 1999
• Outros Autores: Bahia, Daniella Marcia Maranhão [UNIFESP], Franco, Marcello Fabiano de [UNIFESP], Balda, C., Stella, S., Kerbauy, José [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1038/sj.bmt.1701527; http://repositorio.unifesp.br/handle/11600/25998
• topic: nephrotic syndrome; bone marrow transplant; GVHD

GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD, Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis, After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.