Expressao de interleucina-17A em pacientes com polipose nasossinusal

• Autor(a) principal: Avelino, Melissa Ameloti Gomes [UNIFESP]
• Data de Publicação: 2013
• Outros Autores: Wastowski, Isabela Jube, Ferri, Ricardo Gimenes [UNIFESP], Elias, Thais Gomes Abrahao, Lima, Ana Paula Lindoso, Nunes, Larissa Mesquita, Pignatari, Shirley Shizue Nagata [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.5935/1808-8694.20130110; http://repositorio.unifesp.br/handle/11600/7917
• topic: allergy and immunology; interleukin-17; nasal polyps; alergia e imunologia; interleucina-17; polipos nasais

Sinonasal polyposis (SNP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. Interleukin-17A (IL-17A) is a key inflammatory cytokine in many disorders. Little attention has been paid to the role of IL-17A in chronic inflammatory disorders.OBJECTIVE:To investigate the expression of IL-17A in the SNP and verify if this expression is a marker of good or bad prognosis.METHOD:Prospective study with 25 patients presenting with SNP were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups, and asthmatic or non-asthmatic.RESULTS:The IL-17A expression was observed in both atopic and nonatopic patients. The numbers of IL-17A positive cells were greater in nasal polyps of atopic patients than nonatopic (p = 0.0128).CONCLUSION:These results indicate that IL-17A may play an important role in the pathology of SNP. Considering the inflammatory properties of IL-17A, this study suggests that it could increase susceptibility to atopy and asthma.