The human leukocyte antigen G molecule (HLA-G) expression in patients with nasal polyposis

• Autor(a) principal: Avelino, Melissa Ameloti Gomes [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Wastowski, Isabela Jubé, Ferri, Ricardo Gimenes [UNIFESP], Elias, Thaís Gomes Abrahão, Lima, Ana Paula Lindoso, Marinho, Larissa Cardoso [UNIFESP], Pignatari, Shirley Shizue Nagata [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.bjorl.2014.01.001; http://repositorio.unifesp.br/handle/11600/8388
• topic: Nasal polyps; Allergy and immunology; HLA-G antigens; Pólipos nasais; Alergia e imunologia; Antígenos HLA-G

INTRODUCTION:Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. HLA-G molecules are a kind of no classic class I antigen with anti-inflammatory and tolerogenic properties. Little attention has been paid to the role of HLA-G chronic inflammatory disorders.OBJECTIVE:The aim of this study is to investigate the expression of HLA-G in the NP.MATERIALS AND METHODS:Prospective study involving samples of patients presenting with nasal polyposis that were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups and classified as asthmatic or non-asthmatic.RESULTS:Immunohistochemical staining demonstrated a higher expression of the HLA-G molecule in samples from nonatopic than in those from atopic patients, and was significantly lower in the non-asthmatic patients.CONCLUSION:These results indicate that HLA-G may play an important role in the pathology of nasal polyposis. Considering the anti-inflammatory properties of HLA-G, this study suggests that it could reduce susceptibility to atopy and asthma.