Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction

Detalhes bibliográficos
Autor(a) principal: Bonetti, Tatiana C. S. [UNIFESP]
Data de Publicação: 2013
Outros Autores: Borges, Edson, Braga, Daniela P. A. F., Iaconelli, Assumpto, Kleine, Joao P. [UNIFESP], Silva, Ismael D. C. G. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.rbmo.2012.10.001
http://repositorio.unifesp.br/handle/11600/35654
Resumo: The developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency. the receptor for advanced glycation end products (RAGE) is a member of the superfamily of immunoglobulin cell-surface molecules that are constitutively expressed during embryonic development. RAGE is down-regulated in homeostasis in adult life. This study measured the concentration of soluble RAGE (sRAGE) in follicular fluid obtained from the leading follicle after ovarian stimulation of 54 women undergoing intracytoplasmic sperm injection. Corresponding embryos and sRAGE concentrations in follicular fluid were evaluated and correlations were investigated by multi-adjusted regression analysis. High intrafollicular sRAGE concentrations predicted poor-quality embryos (n = 45, OR = 0.986; P = 0.026), adjusted for patient age, body mass index and oocyte quality, showing an inverse association between intrafollicular sRAGE concentrations and embryo development. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier B.V. All rights reserved.
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spelling Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproductionembryo qualityfollicular fluidICSIsRAGEThe developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency. the receptor for advanced glycation end products (RAGE) is a member of the superfamily of immunoglobulin cell-surface molecules that are constitutively expressed during embryonic development. RAGE is down-regulated in homeostasis in adult life. This study measured the concentration of soluble RAGE (sRAGE) in follicular fluid obtained from the leading follicle after ovarian stimulation of 54 women undergoing intracytoplasmic sperm injection. Corresponding embryos and sRAGE concentrations in follicular fluid were evaluated and correlations were investigated by multi-adjusted regression analysis. High intrafollicular sRAGE concentrations predicted poor-quality embryos (n = 45, OR = 0.986; P = 0.026), adjusted for patient age, body mass index and oocyte quality, showing an inverse association between intrafollicular sRAGE concentrations and embryo development. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Gynecol, Mol Gynecol & Prote Lab, BR-04039032 São Paulo, BrazilFertil Assisted Fertilizat Ctr, BR-01401002 São Paulo, BrazilEduc & Res Ctr Assisted Reprod, Sapientiae Inst, BR-04503040 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Gynecol, Mol Gynecol & Prote Lab, BR-04039032 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 2007/58467-0CNPq: 579224/2008-2Elsevier B.V.Universidade Federal de São Paulo (UNIFESP)Fertil Assisted Fertilizat CtrEduc & Res Ctr Assisted ReprodBonetti, Tatiana C. S. [UNIFESP]Borges, EdsonBraga, Daniela P. A. F.Iaconelli, AssumptoKleine, Joao P. [UNIFESP]Silva, Ismael D. C. G. [UNIFESP]2016-01-24T14:30:49Z2016-01-24T14:30:49Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion62-67http://dx.doi.org/10.1016/j.rbmo.2012.10.001Reproductive Biomedicine Online. Oxford: Elsevier B.V., v. 26, n. 1, p. 62-67, 2013.10.1016/j.rbmo.2012.10.0011472-6483http://repositorio.unifesp.br/handle/11600/35654WOS:000313562900010engReproductive Biomedicine Onlineinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-02-15T10:56:35Zoai:repositorio.unifesp.br/:11600/35654Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:56:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
title Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
spellingShingle Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
Bonetti, Tatiana C. S. [UNIFESP]
embryo quality
follicular fluid
ICSI
sRAGE
title_short Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
title_full Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
title_fullStr Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
title_full_unstemmed Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
title_sort Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction
author Bonetti, Tatiana C. S. [UNIFESP]
author_facet Bonetti, Tatiana C. S. [UNIFESP]
Borges, Edson
Braga, Daniela P. A. F.
Iaconelli, Assumpto
Kleine, Joao P. [UNIFESP]
Silva, Ismael D. C. G. [UNIFESP]
author_role author
author2 Borges, Edson
Braga, Daniela P. A. F.
Iaconelli, Assumpto
Kleine, Joao P. [UNIFESP]
Silva, Ismael D. C. G. [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Fertil Assisted Fertilizat Ctr
Educ & Res Ctr Assisted Reprod
dc.contributor.author.fl_str_mv Bonetti, Tatiana C. S. [UNIFESP]
Borges, Edson
Braga, Daniela P. A. F.
Iaconelli, Assumpto
Kleine, Joao P. [UNIFESP]
Silva, Ismael D. C. G. [UNIFESP]
dc.subject.por.fl_str_mv embryo quality
follicular fluid
ICSI
sRAGE
topic embryo quality
follicular fluid
ICSI
sRAGE
description The developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency. the receptor for advanced glycation end products (RAGE) is a member of the superfamily of immunoglobulin cell-surface molecules that are constitutively expressed during embryonic development. RAGE is down-regulated in homeostasis in adult life. This study measured the concentration of soluble RAGE (sRAGE) in follicular fluid obtained from the leading follicle after ovarian stimulation of 54 women undergoing intracytoplasmic sperm injection. Corresponding embryos and sRAGE concentrations in follicular fluid were evaluated and correlations were investigated by multi-adjusted regression analysis. High intrafollicular sRAGE concentrations predicted poor-quality embryos (n = 45, OR = 0.986; P = 0.026), adjusted for patient age, body mass index and oocyte quality, showing an inverse association between intrafollicular sRAGE concentrations and embryo development. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier B.V. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2016-01-24T14:30:49Z
2016-01-24T14:30:49Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.rbmo.2012.10.001
Reproductive Biomedicine Online. Oxford: Elsevier B.V., v. 26, n. 1, p. 62-67, 2013.
10.1016/j.rbmo.2012.10.001
1472-6483
http://repositorio.unifesp.br/handle/11600/35654
WOS:000313562900010
url http://dx.doi.org/10.1016/j.rbmo.2012.10.001
http://repositorio.unifesp.br/handle/11600/35654
identifier_str_mv Reproductive Biomedicine Online. Oxford: Elsevier B.V., v. 26, n. 1, p. 62-67, 2013.
10.1016/j.rbmo.2012.10.001
1472-6483
WOS:000313562900010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproductive Biomedicine Online
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 62-67
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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