Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/30670 http://dx.doi.org/10.1016/j.ejheart.2008.03.016 |
Resumo: | Background: Sustained beta-adrenoreceptor activation promotes cardiac hypertrophy and cellular injury.Aims: To evaluate the cardioprotective effect of exercise on damage induced by beta-adrenergic hyperactivity.Methods: Male Wistar rats were randomised into four groups (n=8 per group): sedentary non-treated control (C), sedentary treated with isoproterenol 0.3 mg/kg/day administered subcutaneously for 8 days (1), exercised non-treated (E) and exercised plus isoproterenol administered during the last eight days of exercise (IE). Exercised animals ran on a treadmill for 1 h daily 6 times a week for 13 weeks.Results: Isoproterenol caused increases in left ventricle (LV) wet and dry weight/body weight ratio, LV water content and cardiomyocyte transverse diameter. Additionally, isoproterenol induced severe cellular lesions, necrosis, and apoptosis, increased collagen content and reduced capillary and fibre fractional areas. Notably, all of these abnormalities were completely prevented by exercise.Conclusion: Our data have demonstrated that complete cardioprotection is possible through exercise training; by preventing p-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. |
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Serra, Andrey Jorge [UNIFESP]Higuchi, Maria L.Ihara, Silvia Saiuli Miki [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Santos, Marilia H. H.Bombig, Maria Teresa Nogueira [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T13:51:23Z2016-01-24T13:51:23Z2008-06-01European Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 10, n. 6, p. 534-539, 2008.1388-9842http://repositorio.unifesp.br/handle/11600/30670http://dx.doi.org/10.1016/j.ejheart.2008.03.01610.1016/j.ejheart.2008.03.016WOS:000257618500003Background: Sustained beta-adrenoreceptor activation promotes cardiac hypertrophy and cellular injury.Aims: To evaluate the cardioprotective effect of exercise on damage induced by beta-adrenergic hyperactivity.Methods: Male Wistar rats were randomised into four groups (n=8 per group): sedentary non-treated control (C), sedentary treated with isoproterenol 0.3 mg/kg/day administered subcutaneously for 8 days (1), exercised non-treated (E) and exercised plus isoproterenol administered during the last eight days of exercise (IE). Exercised animals ran on a treadmill for 1 h daily 6 times a week for 13 weeks.Results: Isoproterenol caused increases in left ventricle (LV) wet and dry weight/body weight ratio, LV water content and cardiomyocyte transverse diameter. Additionally, isoproterenol induced severe cellular lesions, necrosis, and apoptosis, increased collagen content and reduced capillary and fibre fractional areas. Notably, all of these abnormalities were completely prevented by exercise.Conclusion: Our data have demonstrated that complete cardioprotection is possible through exercise training; by preventing p-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Div Cardiol, Dept Med, São Paulo, BrazilUniv São Paulo, INCOR, Inst Heart, BR-05508 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Cardiovasc, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Cardiol, Dept Med, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Cardiovasc, Dept Physiol, São Paulo, BrazilWeb of Science534-539engElsevier B.V.European Journal of Heart Failurehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessmyocardial hypertrophyisoproterenolexercise trainingcardioprotectionExercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/306702023-01-30 22:20:24.716metadata only accessoai:repositorio.unifesp.br:11600/30670Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-31T01:20:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
title |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
spellingShingle |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions Serra, Andrey Jorge [UNIFESP] myocardial hypertrophy isoproterenol exercise training cardioprotection |
title_short |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
title_full |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
title_fullStr |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
title_full_unstemmed |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
title_sort |
Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions |
author |
Serra, Andrey Jorge [UNIFESP] |
author_facet |
Serra, Andrey Jorge [UNIFESP] Higuchi, Maria L. Ihara, Silvia Saiuli Miki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Marilia H. H. Bombig, Maria Teresa Nogueira [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author_role |
author |
author2 |
Higuchi, Maria L. Ihara, Silvia Saiuli Miki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Marilia H. H. Bombig, Maria Teresa Nogueira [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Serra, Andrey Jorge [UNIFESP] Higuchi, Maria L. Ihara, Silvia Saiuli Miki [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Marilia H. H. Bombig, Maria Teresa Nogueira [UNIFESP] Tucci, Paulo José Ferreira [UNIFESP] |
dc.subject.eng.fl_str_mv |
myocardial hypertrophy isoproterenol exercise training cardioprotection |
topic |
myocardial hypertrophy isoproterenol exercise training cardioprotection |
description |
Background: Sustained beta-adrenoreceptor activation promotes cardiac hypertrophy and cellular injury.Aims: To evaluate the cardioprotective effect of exercise on damage induced by beta-adrenergic hyperactivity.Methods: Male Wistar rats were randomised into four groups (n=8 per group): sedentary non-treated control (C), sedentary treated with isoproterenol 0.3 mg/kg/day administered subcutaneously for 8 days (1), exercised non-treated (E) and exercised plus isoproterenol administered during the last eight days of exercise (IE). Exercised animals ran on a treadmill for 1 h daily 6 times a week for 13 weeks.Results: Isoproterenol caused increases in left ventricle (LV) wet and dry weight/body weight ratio, LV water content and cardiomyocyte transverse diameter. Additionally, isoproterenol induced severe cellular lesions, necrosis, and apoptosis, increased collagen content and reduced capillary and fibre fractional areas. Notably, all of these abnormalities were completely prevented by exercise.Conclusion: Our data have demonstrated that complete cardioprotection is possible through exercise training; by preventing p-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:51:23Z |
dc.date.available.fl_str_mv |
2016-01-24T13:51:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
European Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 10, n. 6, p. 534-539, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/30670 http://dx.doi.org/10.1016/j.ejheart.2008.03.016 |
dc.identifier.issn.none.fl_str_mv |
1388-9842 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejheart.2008.03.016 |
dc.identifier.wos.none.fl_str_mv |
WOS:000257618500003 |
identifier_str_mv |
European Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 10, n. 6, p. 534-539, 2008. 1388-9842 10.1016/j.ejheart.2008.03.016 WOS:000257618500003 |
url |
http://repositorio.unifesp.br/handle/11600/30670 http://dx.doi.org/10.1016/j.ejheart.2008.03.016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
European Journal of Heart Failure |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
534-539 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764281834373120 |