Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33709 http://dx.doi.org/10.1371/journal.pone.0019690 |
Resumo: | Paracoccidioidomycosis is a mycotic disease caused by a dimorphic fungus, Paracoccidioides brasiliensis (Pb), that starts with inhalation of the fungus; thus, lung cells such as DC are part of the first line of defense against this microorganism. Migration of DC to the lymph nodes is the first step in initiating T cell responses. the mechanisms involved in resistance to Pb infection are poorly understood, but it is likely that DC play a pivotal role in the induction of effector T cells that control Pb infection. in this study, we showed that after Pb Infection, an important modification of lung DC receptor expression occurred. We observed an increased expression of CCR7 and CD103 on lung DC after infection, as well as MHC-II. After Pb infection, bone marrow-derived DC as well lung DC, migrate to lymph nodes. Migration of lung DC could represent an important mechanism of pathogenesis during PCM infection. in resume our data showed that Pb induced DC migration. Furthermore, we demonstrated that bone marrow-derived DC stimulated by Pb migrate to the lymph nodes and activate a T helper (Th) response. To the best of our knowledge, this is the first reported data showing that Pb induces migration of DC and activate a T helper (Th) response. |
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Santos, Suelen Silvana dosFerreira, Karen Spadari [UNIFESP]Almeida, Sandro RogerioUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:16:46Z2016-01-24T14:16:46Z2011-05-18Plos One. San Francisco: Public Library Science, v. 6, n. 5, 8 p., 2011.1932-6203http://repositorio.unifesp.br/handle/11600/33709http://dx.doi.org/10.1371/journal.pone.0019690WOS000290720200026.pdf10.1371/journal.pone.0019690WOS:000290720200026Paracoccidioidomycosis is a mycotic disease caused by a dimorphic fungus, Paracoccidioides brasiliensis (Pb), that starts with inhalation of the fungus; thus, lung cells such as DC are part of the first line of defense against this microorganism. Migration of DC to the lymph nodes is the first step in initiating T cell responses. the mechanisms involved in resistance to Pb infection are poorly understood, but it is likely that DC play a pivotal role in the induction of effector T cells that control Pb infection. in this study, we showed that after Pb Infection, an important modification of lung DC receptor expression occurred. We observed an increased expression of CCR7 and CD103 on lung DC after infection, as well as MHC-II. After Pb infection, bone marrow-derived DC as well lung DC, migrate to lymph nodes. Migration of lung DC could represent an important mechanism of pathogenesis during PCM infection. in resume our data showed that Pb induced DC migration. Furthermore, we demonstrated that bone marrow-derived DC stimulated by Pb migrate to the lymph nodes and activate a T helper (Th) response. To the best of our knowledge, this is the first reported data showing that Pb induces migration of DC and activate a T helper (Th) response.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao de de Amparo a Pesquisa do Estado de São PauloUniv São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, BrazilFundacao de de Amparo a Pesquisa do Estado de São Paulo: 07/57594-9Web of Science8engPublic Library SciencePlos OneParacoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000290720200026.pdfapplication/pdf1033610${dspace.ui.url}/bitstream/11600/33709/1/WOS000290720200026.pdfb9b6769a85af97ab6177f9952b5856c4MD51open accessTEXTWOS000290720200026.pdf.txtWOS000290720200026.pdf.txtExtracted texttext/plain28589${dspace.ui.url}/bitstream/11600/33709/9/WOS000290720200026.pdf.txtfae78583d419d817211e8bf564adede3MD59open accessTHUMBNAILWOS000290720200026.pdf.jpgWOS000290720200026.pdf.jpgIM Thumbnailimage/jpeg7821${dspace.ui.url}/bitstream/11600/33709/11/WOS000290720200026.pdf.jpgcdb2abd56f3525f241be24d59c2d66ddMD511open access11600/337092023-06-05 19:21:03.276open accessoai:repositorio.unifesp.br:11600/33709Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:21:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
title |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
spellingShingle |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes Santos, Suelen Silvana dos |
title_short |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
title_full |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
title_fullStr |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
title_full_unstemmed |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
title_sort |
Paracoccidioides brasilinsis-Induced Migration of Dendritic Cells and Subsequent T-Cell Activation in the Lung-Draining Lymph Nodes |
author |
Santos, Suelen Silvana dos |
author_facet |
Santos, Suelen Silvana dos Ferreira, Karen Spadari [UNIFESP] Almeida, Sandro Rogerio |
author_role |
author |
author2 |
Ferreira, Karen Spadari [UNIFESP] Almeida, Sandro Rogerio |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santos, Suelen Silvana dos Ferreira, Karen Spadari [UNIFESP] Almeida, Sandro Rogerio |
description |
Paracoccidioidomycosis is a mycotic disease caused by a dimorphic fungus, Paracoccidioides brasiliensis (Pb), that starts with inhalation of the fungus; thus, lung cells such as DC are part of the first line of defense against this microorganism. Migration of DC to the lymph nodes is the first step in initiating T cell responses. the mechanisms involved in resistance to Pb infection are poorly understood, but it is likely that DC play a pivotal role in the induction of effector T cells that control Pb infection. in this study, we showed that after Pb Infection, an important modification of lung DC receptor expression occurred. We observed an increased expression of CCR7 and CD103 on lung DC after infection, as well as MHC-II. After Pb infection, bone marrow-derived DC as well lung DC, migrate to lymph nodes. Migration of lung DC could represent an important mechanism of pathogenesis during PCM infection. in resume our data showed that Pb induced DC migration. Furthermore, we demonstrated that bone marrow-derived DC stimulated by Pb migrate to the lymph nodes and activate a T helper (Th) response. To the best of our knowledge, this is the first reported data showing that Pb induces migration of DC and activate a T helper (Th) response. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-05-18 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:16:46Z |
dc.date.available.fl_str_mv |
2016-01-24T14:16:46Z |
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info:eu-repo/semantics/publishedVersion |
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format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Plos One. San Francisco: Public Library Science, v. 6, n. 5, 8 p., 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33709 http://dx.doi.org/10.1371/journal.pone.0019690 |
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1932-6203 |
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WOS000290720200026.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0019690 |
dc.identifier.wos.none.fl_str_mv |
WOS:000290720200026 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 6, n. 5, 8 p., 2011. 1932-6203 WOS000290720200026.pdf 10.1371/journal.pone.0019690 WOS:000290720200026 |
url |
http://repositorio.unifesp.br/handle/11600/33709 http://dx.doi.org/10.1371/journal.pone.0019690 |
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Public Library Science |
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Public Library Science |
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