Fungicidal activity of peptides encoded by immunoglobulin genes

Detalhes bibliográficos
Autor(a) principal: Polonelli, Luciano
Data de Publicação: 2017
Outros Autores: Ciociola, Tecla, Sperinde, Martina, Giovati, Laura, D'Adda, Tiziana, Galati, Serena, Travassos, Luiz R. [UNIFESP], Magliani, Walter, Conti, Stefania
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1038/s41598-017-11396-6
https://repositorio.unifesp.br/handle/11600/57372
Resumo: Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.
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spelling Fungicidal activity of peptides encoded by immunoglobulin genesEvidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.Univ Parma, Dept Med & Surg, Parma, ItalyUniv Parma, Dept Chem Life Sci & Environm Sustainabil, Parma, ItalyFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Expt Oncol Unit, Sao Paulo, BrazilWeb of ScienceNature Publishing Group2020-08-04T13:40:12Z2020-08-04T13:40:12Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1038/s41598-017-11396-6Scientific Reports. London, v. 7, p. -, 2017.10.1038/s41598-017-11396-6WOS000409562000043.pdf2045-2322https://repositorio.unifesp.br/handle/11600/57372WOS:000409562000043engScientific ReportsLondoninfo:eu-repo/semantics/openAccessPolonelli, LucianoCiociola, TeclaSperinde, MartinaGiovati, LauraD'Adda, TizianaGalati, SerenaTravassos, Luiz R. [UNIFESP]Magliani, WalterConti, Stefaniareponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T05:30:05Zoai:repositorio.unifesp.br/:11600/57372Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T05:30:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Fungicidal activity of peptides encoded by immunoglobulin genes
title Fungicidal activity of peptides encoded by immunoglobulin genes
spellingShingle Fungicidal activity of peptides encoded by immunoglobulin genes
Polonelli, Luciano
title_short Fungicidal activity of peptides encoded by immunoglobulin genes
title_full Fungicidal activity of peptides encoded by immunoglobulin genes
title_fullStr Fungicidal activity of peptides encoded by immunoglobulin genes
title_full_unstemmed Fungicidal activity of peptides encoded by immunoglobulin genes
title_sort Fungicidal activity of peptides encoded by immunoglobulin genes
author Polonelli, Luciano
author_facet Polonelli, Luciano
Ciociola, Tecla
Sperinde, Martina
Giovati, Laura
D'Adda, Tiziana
Galati, Serena
Travassos, Luiz R. [UNIFESP]
Magliani, Walter
Conti, Stefania
author_role author
author2 Ciociola, Tecla
Sperinde, Martina
Giovati, Laura
D'Adda, Tiziana
Galati, Serena
Travassos, Luiz R. [UNIFESP]
Magliani, Walter
Conti, Stefania
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Polonelli, Luciano
Ciociola, Tecla
Sperinde, Martina
Giovati, Laura
D'Adda, Tiziana
Galati, Serena
Travassos, Luiz R. [UNIFESP]
Magliani, Walter
Conti, Stefania
description Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-08-04T13:40:12Z
2020-08-04T13:40:12Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/s41598-017-11396-6
Scientific Reports. London, v. 7, p. -, 2017.
10.1038/s41598-017-11396-6
WOS000409562000043.pdf
2045-2322
https://repositorio.unifesp.br/handle/11600/57372
WOS:000409562000043
url http://dx.doi.org/10.1038/s41598-017-11396-6
https://repositorio.unifesp.br/handle/11600/57372
identifier_str_mv Scientific Reports. London, v. 7, p. -, 2017.
10.1038/s41598-017-11396-6
WOS000409562000043.pdf
2045-2322
WOS:000409562000043
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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