Peptides of the Constant Region of Antibodies Display Fungicidal Activity
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0034105 http://repositorio.unifesp.br/handle/11600/34716 |
Resumo: | Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents. |
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Peptides of the Constant Region of Antibodies Display Fungicidal ActivitySynthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.Univ Parma, Dipartimento Patol & Med Lab, Sez Microbiol, I-43100 Parma, ItalyUniv Parma, Dipartimento Patol & Med Lab, Sez Anat & Istol Patol, I-43100 Parma, ItalyUniv Parma, Dipartimento Genet Biol Microrganismi Antropol, I-43100 Parma, ItalyIst Super Sanita, Dipartimento Malattie Infettive Parassitarie & Im, I-00161 Rome, ItalyUniv Perugia, Dipartimento Med Sperimentale & Sci Biochim, Sez Microbiol, I-06100 Perugia, ItalyUniversidade Federal de São Paulo, Unidade Oncol Expt, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUniv São Paulo, Dept Microbiol, BR-05508 São Paulo, BrazilUniv Parma, Dipartimento Med Sperimentale, I-43100 Parma, ItalyUniversidade Federal de São Paulo, Unidade Oncol Expt, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilWeb of ScienceItalian Ministry of HealthItalian Ministry of Health: 40H39Public Library ScienceUniv ParmaIst Super SanitaUniv PerugiaUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Polonelli, LucianoCiociola, TeclaMagliani, WalterZanello, Pier PaoloD'Adda, TizianaGalati, SerenaDe Bernardis, FlaviaArancia, SilviaGabrielli, ElenaPericolini, EvaVecchiarelli, AnnaArruda, Denise C. [UNIFESP]Pinto, Marcia R.Travassos, Luiz Rodolpho [UNIFESP]Pertinhez, Thelma A.Spisni, AlbertoConti, Stefania2016-01-24T14:26:59Z2016-01-24T14:26:59Z2012-03-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10application/pdfhttp://dx.doi.org/10.1371/journal.pone.0034105Plos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012.10.1371/journal.pone.0034105WOS000303857100067.pdf1932-6203http://repositorio.unifesp.br/handle/11600/34716WOS:000303857100067engPlos Oneinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T11:35:45Zoai:repositorio.unifesp.br/:11600/34716Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T11:35:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
title |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
spellingShingle |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity Polonelli, Luciano |
title_short |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
title_full |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
title_fullStr |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
title_full_unstemmed |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
title_sort |
Peptides of the Constant Region of Antibodies Display Fungicidal Activity |
author |
Polonelli, Luciano |
author_facet |
Polonelli, Luciano Ciociola, Tecla Magliani, Walter Zanello, Pier Paolo D'Adda, Tiziana Galati, Serena De Bernardis, Flavia Arancia, Silvia Gabrielli, Elena Pericolini, Eva Vecchiarelli, Anna Arruda, Denise C. [UNIFESP] Pinto, Marcia R. Travassos, Luiz Rodolpho [UNIFESP] Pertinhez, Thelma A. Spisni, Alberto Conti, Stefania |
author_role |
author |
author2 |
Ciociola, Tecla Magliani, Walter Zanello, Pier Paolo D'Adda, Tiziana Galati, Serena De Bernardis, Flavia Arancia, Silvia Gabrielli, Elena Pericolini, Eva Vecchiarelli, Anna Arruda, Denise C. [UNIFESP] Pinto, Marcia R. Travassos, Luiz Rodolpho [UNIFESP] Pertinhez, Thelma A. Spisni, Alberto Conti, Stefania |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Parma Ist Super Sanita Univ Perugia Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Polonelli, Luciano Ciociola, Tecla Magliani, Walter Zanello, Pier Paolo D'Adda, Tiziana Galati, Serena De Bernardis, Flavia Arancia, Silvia Gabrielli, Elena Pericolini, Eva Vecchiarelli, Anna Arruda, Denise C. [UNIFESP] Pinto, Marcia R. Travassos, Luiz Rodolpho [UNIFESP] Pertinhez, Thelma A. Spisni, Alberto Conti, Stefania |
description |
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03-21 2016-01-24T14:26:59Z 2016-01-24T14:26:59Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0034105 Plos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012. 10.1371/journal.pone.0034105 WOS000303857100067.pdf 1932-6203 http://repositorio.unifesp.br/handle/11600/34716 WOS:000303857100067 |
url |
http://dx.doi.org/10.1371/journal.pone.0034105 http://repositorio.unifesp.br/handle/11600/34716 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012. 10.1371/journal.pone.0034105 WOS000303857100067.pdf 1932-6203 WOS:000303857100067 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos One |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268428419072000 |