IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.leukres.2013.01.019 http://repositorio.unifesp.br/handle/11600/36229 |
Resumo: | The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved. |
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IL10 inversely correlates with the percentage of CD8(+) cells in MDS patientsMyelodysplastic SyndromeIL10CD8(+) cellsImmune SystemThe role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved.Univ Estadual Campinas, Haematol & Hemotherapy Ctr, Hemoctr Unicamp, Inst Nacl Ciencia & Tecnol Sangue, São Paulo, BrazilUniv Estadual Campinas, Sch Med Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Elsevier B.V.Universidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)Lopes, Matheus RodriguesTraina, FabíolaCampos, Paula de MeloPereira, João Kleber NovaisMachado-Neto, João AgostinhoMachado, Helymar da CostaGilli, Simone Cristina OlensckiSaad, Sara Teresinha OlallaFavaro, Patricia [UNIFESP]2016-01-24T14:31:36Z2016-01-24T14:31:36Z2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion541-546application/pdfhttp://dx.doi.org/10.1016/j.leukres.2013.01.019Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013.10.1016/j.leukres.2013.01.019WOS000317264500012.pdf0145-2126http://repositorio.unifesp.br/handle/11600/36229WOS:000317264500012engLeukemia Researchinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T20:26:22Zoai:repositorio.unifesp.br/:11600/36229Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T20:26:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| title |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| spellingShingle |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients Lopes, Matheus Rodrigues Myelodysplastic Syndrome IL10 CD8(+) cells Immune System |
| title_short |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| title_full |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| title_fullStr |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| title_full_unstemmed |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| title_sort |
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients |
| author |
Lopes, Matheus Rodrigues |
| author_facet |
Lopes, Matheus Rodrigues Traina, Fabíola Campos, Paula de Melo Pereira, João Kleber Novais Machado-Neto, João Agostinho Machado, Helymar da Costa Gilli, Simone Cristina Olenscki Saad, Sara Teresinha Olalla Favaro, Patricia [UNIFESP] |
| author_role |
author |
| author2 |
Traina, Fabíola Campos, Paula de Melo Pereira, João Kleber Novais Machado-Neto, João Agostinho Machado, Helymar da Costa Gilli, Simone Cristina Olenscki Saad, Sara Teresinha Olalla Favaro, Patricia [UNIFESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Lopes, Matheus Rodrigues Traina, Fabíola Campos, Paula de Melo Pereira, João Kleber Novais Machado-Neto, João Agostinho Machado, Helymar da Costa Gilli, Simone Cristina Olenscki Saad, Sara Teresinha Olalla Favaro, Patricia [UNIFESP] |
| dc.subject.por.fl_str_mv |
Myelodysplastic Syndrome IL10 CD8(+) cells Immune System |
| topic |
Myelodysplastic Syndrome IL10 CD8(+) cells Immune System |
| description |
The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier B.V. All rights reserved. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-05-01 2016-01-24T14:31:36Z 2016-01-24T14:31:36Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.leukres.2013.01.019 Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013. 10.1016/j.leukres.2013.01.019 WOS000317264500012.pdf 0145-2126 http://repositorio.unifesp.br/handle/11600/36229 WOS:000317264500012 |
| url |
http://dx.doi.org/10.1016/j.leukres.2013.01.019 http://repositorio.unifesp.br/handle/11600/36229 |
| identifier_str_mv |
Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 37, n. 5, p. 541-546, 2013. 10.1016/j.leukres.2013.01.019 WOS000317264500012.pdf 0145-2126 WOS:000317264500012 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Leukemia Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| dc.format.none.fl_str_mv |
541-546 application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
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UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268406354935808 |