The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients

Detalhes bibliográficos
Autor(a) principal: Tomiyama, Cristianne [UNIFESP]
Data de Publicação: 2006
Outros Autores: Higa, Andrea [UNIFESP], Dalboni, Maria Aparecida [UNIFESP], Cendoroglo, Miguel [UNIFESP], Draibe, Sergio A. [UNIFESP], Cuppari, Lilian [UNIFESP], Carvalho, Aluizio B. [UNIFESP], Neto, Emilio M. [UNIFESP], Canziani, Maria Eugenia F. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1093/ndt/gfl291
http://repositorio.unifesp.br/handle/11600/29109
Resumo: Background. Coronary heart disease (CHD) is the leading cause of death among end-stage renal disease patients. There is evidence that coronary calcification is a marker of atherosclerotic vascular disease and is predictive of cardiovascular events, especially in patients on renal replacement therapy. It has recently been suggested that CHD begins in the pre-dialysis period. However, data regarding coronary calcification in this population is scarce. This study was aimed at evaluating such coronary calcification and identifying related factors.Methods. A total of 96 chronic kidney disease out-patients who were not on dialysis were included. Patients presenting neoplastic, infectious or inflammatory diseases were excluded. Demographic characteristics, clinical profiles, laboratory test results and multislice computed tomography scans were evaluated.Results. the median age was 55 years (range 20-69 years), 67% were men and the median creatinine clearance was 37 ml/min/1.73 m(2). Coronary calcification, defined as a coronary artery calcification score (CACS) > 0 Agatston units (AU), was seen in 61 patients (median 89.1 AU, range 0.37-2299.3 AU). On average, these patients were older, more often had diabetes, higher body mass indices and higher Framingham risk indices, as well as presenting higher proteinuria, intact parathyroid hormone (iPTH), blood glucose and triglyceride levels compared with those without calcification. Multiple logistic regression analysis, adjusted for age and diabetes, identified iPTH and triglyceride levels as independent determinants of calcification. Severe calcification (CACS > 400 AU) was seen in 22 patients, who were also older and more frequently had a history of cardiovascular disease (CVD), as well as having higher levels of phosphorus, blood glucose and soluble Fas (sFas). Multiple logistic regression analysis, adjusted for age and diabetes, identified phosphorus and sFas levels as independent determinants of severe coronary calcification.Conclusion. Coronary calcification is highly prevalent in pre-dialysis patients and correlates with traditional and non-traditional risk factors for CVD.
id UFSP_2b2128c0b38df917128be11e6560b2b4
oai_identifier_str oai:repositorio.unifesp.br/:11600/29109
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patientschronic kidney diseasecoronary arteriosclerosismultislice computed tomographyvascular calcificationBackground. Coronary heart disease (CHD) is the leading cause of death among end-stage renal disease patients. There is evidence that coronary calcification is a marker of atherosclerotic vascular disease and is predictive of cardiovascular events, especially in patients on renal replacement therapy. It has recently been suggested that CHD begins in the pre-dialysis period. However, data regarding coronary calcification in this population is scarce. This study was aimed at evaluating such coronary calcification and identifying related factors.Methods. A total of 96 chronic kidney disease out-patients who were not on dialysis were included. Patients presenting neoplastic, infectious or inflammatory diseases were excluded. Demographic characteristics, clinical profiles, laboratory test results and multislice computed tomography scans were evaluated.Results. the median age was 55 years (range 20-69 years), 67% were men and the median creatinine clearance was 37 ml/min/1.73 m(2). Coronary calcification, defined as a coronary artery calcification score (CACS) > 0 Agatston units (AU), was seen in 61 patients (median 89.1 AU, range 0.37-2299.3 AU). On average, these patients were older, more often had diabetes, higher body mass indices and higher Framingham risk indices, as well as presenting higher proteinuria, intact parathyroid hormone (iPTH), blood glucose and triglyceride levels compared with those without calcification. Multiple logistic regression analysis, adjusted for age and diabetes, identified iPTH and triglyceride levels as independent determinants of calcification. Severe calcification (CACS > 400 AU) was seen in 22 patients, who were also older and more frequently had a history of cardiovascular disease (CVD), as well as having higher levels of phosphorus, blood glucose and soluble Fas (sFas). Multiple logistic regression analysis, adjusted for age and diabetes, identified phosphorus and sFas levels as independent determinants of severe coronary calcification.Conclusion. Coronary calcification is highly prevalent in pre-dialysis patients and correlates with traditional and non-traditional risk factors for CVD.Universidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilBrazil Diagnost Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilWeb of ScienceOxford Univ PressUniversidade Federal de São Paulo (UNIFESP)Brazil Diagnost CtrTomiyama, Cristianne [UNIFESP]Higa, Andrea [UNIFESP]Dalboni, Maria Aparecida [UNIFESP]Cendoroglo, Miguel [UNIFESP]Draibe, Sergio A. [UNIFESP]Cuppari, Lilian [UNIFESP]Carvalho, Aluizio B. [UNIFESP]Neto, Emilio M. [UNIFESP]Canziani, Maria Eugenia F. [UNIFESP]2016-01-24T12:41:25Z2016-01-24T12:41:25Z2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2464-2471http://dx.doi.org/10.1093/ndt/gfl291Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 21, n. 9, p. 2464-2471, 2006.10.1093/ndt/gfl2910931-0509http://repositorio.unifesp.br/handle/11600/29109WOS:000240694200021engNephrology Dialysis Transplantationinfo:eu-repo/semantics/openAccesshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T10:41:25Zoai:repositorio.unifesp.br/:11600/29109Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T10:41:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
title The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
spellingShingle The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
Tomiyama, Cristianne [UNIFESP]
chronic kidney disease
coronary arteriosclerosis
multislice computed tomography
vascular calcification
title_short The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
title_full The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
title_fullStr The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
title_full_unstemmed The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
title_sort The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients
author Tomiyama, Cristianne [UNIFESP]
author_facet Tomiyama, Cristianne [UNIFESP]
Higa, Andrea [UNIFESP]
Dalboni, Maria Aparecida [UNIFESP]
Cendoroglo, Miguel [UNIFESP]
Draibe, Sergio A. [UNIFESP]
Cuppari, Lilian [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Neto, Emilio M. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
author_role author
author2 Higa, Andrea [UNIFESP]
Dalboni, Maria Aparecida [UNIFESP]
Cendoroglo, Miguel [UNIFESP]
Draibe, Sergio A. [UNIFESP]
Cuppari, Lilian [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Neto, Emilio M. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Brazil Diagnost Ctr
dc.contributor.author.fl_str_mv Tomiyama, Cristianne [UNIFESP]
Higa, Andrea [UNIFESP]
Dalboni, Maria Aparecida [UNIFESP]
Cendoroglo, Miguel [UNIFESP]
Draibe, Sergio A. [UNIFESP]
Cuppari, Lilian [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Neto, Emilio M. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
dc.subject.por.fl_str_mv chronic kidney disease
coronary arteriosclerosis
multislice computed tomography
vascular calcification
topic chronic kidney disease
coronary arteriosclerosis
multislice computed tomography
vascular calcification
description Background. Coronary heart disease (CHD) is the leading cause of death among end-stage renal disease patients. There is evidence that coronary calcification is a marker of atherosclerotic vascular disease and is predictive of cardiovascular events, especially in patients on renal replacement therapy. It has recently been suggested that CHD begins in the pre-dialysis period. However, data regarding coronary calcification in this population is scarce. This study was aimed at evaluating such coronary calcification and identifying related factors.Methods. A total of 96 chronic kidney disease out-patients who were not on dialysis were included. Patients presenting neoplastic, infectious or inflammatory diseases were excluded. Demographic characteristics, clinical profiles, laboratory test results and multislice computed tomography scans were evaluated.Results. the median age was 55 years (range 20-69 years), 67% were men and the median creatinine clearance was 37 ml/min/1.73 m(2). Coronary calcification, defined as a coronary artery calcification score (CACS) > 0 Agatston units (AU), was seen in 61 patients (median 89.1 AU, range 0.37-2299.3 AU). On average, these patients were older, more often had diabetes, higher body mass indices and higher Framingham risk indices, as well as presenting higher proteinuria, intact parathyroid hormone (iPTH), blood glucose and triglyceride levels compared with those without calcification. Multiple logistic regression analysis, adjusted for age and diabetes, identified iPTH and triglyceride levels as independent determinants of calcification. Severe calcification (CACS > 400 AU) was seen in 22 patients, who were also older and more frequently had a history of cardiovascular disease (CVD), as well as having higher levels of phosphorus, blood glucose and soluble Fas (sFas). Multiple logistic regression analysis, adjusted for age and diabetes, identified phosphorus and sFas levels as independent determinants of severe coronary calcification.Conclusion. Coronary calcification is highly prevalent in pre-dialysis patients and correlates with traditional and non-traditional risk factors for CVD.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-01
2016-01-24T12:41:25Z
2016-01-24T12:41:25Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/ndt/gfl291
Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 21, n. 9, p. 2464-2471, 2006.
10.1093/ndt/gfl291
0931-0509
http://repositorio.unifesp.br/handle/11600/29109
WOS:000240694200021
url http://dx.doi.org/10.1093/ndt/gfl291
http://repositorio.unifesp.br/handle/11600/29109
identifier_str_mv Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 21, n. 9, p. 2464-2471, 2006.
10.1093/ndt/gfl291
0931-0509
WOS:000240694200021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nephrology Dialysis Transplantation
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.format.none.fl_str_mv 2464-2471
dc.publisher.none.fl_str_mv Oxford Univ Press
publisher.none.fl_str_mv Oxford Univ Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268373324791808