Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1359/jbmr.090735 http://repositorio.unifesp.br/handle/11600/32302 |
Resumo: | Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research. |
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Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis TreatmentCHRONIC KIDNEY DISEASEPREDIALYSISCORONARY CALCIFICATIONBONE MINERAL METABOLISMBONE-FORMATION RATEVascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research.Universidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilUniv São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilWeb of ScienceWiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Tomiyama, Cristianne [UNIFESP]Carvalho, Aluizio B. [UNIFESP]Higa, Andrea [UNIFESP]Jorgetti, VandaDraibe, Sergio A. [UNIFESP]Canziani, Maria Eugenia F. [UNIFESP]2016-01-24T13:59:22Z2016-01-24T13:59:22Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion499-504http://dx.doi.org/10.1359/jbmr.090735Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010.10.1359/jbmr.0907350884-0431http://repositorio.unifesp.br/handle/11600/32302WOS:000276767700010engJournal of Bone and Mineral Researchinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-02-15T10:56:35Zoai:repositorio.unifesp.br/:11600/32302Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:56:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
title |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
spellingShingle |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment Tomiyama, Cristianne [UNIFESP] CHRONIC KIDNEY DISEASE PREDIALYSIS CORONARY CALCIFICATION BONE MINERAL METABOLISM BONE-FORMATION RATE |
title_short |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
title_full |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
title_fullStr |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
title_full_unstemmed |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
title_sort |
Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment |
author |
Tomiyama, Cristianne [UNIFESP] |
author_facet |
Tomiyama, Cristianne [UNIFESP] Carvalho, Aluizio B. [UNIFESP] Higa, Andrea [UNIFESP] Jorgetti, Vanda Draibe, Sergio A. [UNIFESP] Canziani, Maria Eugenia F. [UNIFESP] |
author_role |
author |
author2 |
Carvalho, Aluizio B. [UNIFESP] Higa, Andrea [UNIFESP] Jorgetti, Vanda Draibe, Sergio A. [UNIFESP] Canziani, Maria Eugenia F. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Tomiyama, Cristianne [UNIFESP] Carvalho, Aluizio B. [UNIFESP] Higa, Andrea [UNIFESP] Jorgetti, Vanda Draibe, Sergio A. [UNIFESP] Canziani, Maria Eugenia F. [UNIFESP] |
dc.subject.por.fl_str_mv |
CHRONIC KIDNEY DISEASE PREDIALYSIS CORONARY CALCIFICATION BONE MINERAL METABOLISM BONE-FORMATION RATE |
topic |
CHRONIC KIDNEY DISEASE PREDIALYSIS CORONARY CALCIFICATION BONE MINERAL METABOLISM BONE-FORMATION RATE |
description |
Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 2016-01-24T13:59:22Z 2016-01-24T13:59:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1359/jbmr.090735 Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010. 10.1359/jbmr.090735 0884-0431 http://repositorio.unifesp.br/handle/11600/32302 WOS:000276767700010 |
url |
http://dx.doi.org/10.1359/jbmr.090735 http://repositorio.unifesp.br/handle/11600/32302 |
identifier_str_mv |
Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010. 10.1359/jbmr.090735 0884-0431 WOS:000276767700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Bone and Mineral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
dc.format.none.fl_str_mv |
499-504 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268333730562048 |