Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment

Detalhes bibliográficos
Autor(a) principal: Tomiyama, Cristianne [UNIFESP]
Data de Publicação: 2010
Outros Autores: Carvalho, Aluizio B. [UNIFESP], Higa, Andrea [UNIFESP], Jorgetti, Vanda, Draibe, Sergio A. [UNIFESP], Canziani, Maria Eugenia F. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1359/jbmr.090735
http://repositorio.unifesp.br/handle/11600/32302
Resumo: Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research.
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spelling Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis TreatmentCHRONIC KIDNEY DISEASEPREDIALYSISCORONARY CALCIFICATIONBONE MINERAL METABOLISMBONE-FORMATION RATEVascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research.Universidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilUniv São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Internal Med, Div Nephrol, São Paulo, BrazilWeb of ScienceWiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Tomiyama, Cristianne [UNIFESP]Carvalho, Aluizio B. [UNIFESP]Higa, Andrea [UNIFESP]Jorgetti, VandaDraibe, Sergio A. [UNIFESP]Canziani, Maria Eugenia F. [UNIFESP]2016-01-24T13:59:22Z2016-01-24T13:59:22Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion499-504http://dx.doi.org/10.1359/jbmr.090735Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010.10.1359/jbmr.0907350884-0431http://repositorio.unifesp.br/handle/11600/32302WOS:000276767700010engJournal of Bone and Mineral Researchinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-02-15T10:56:35Zoai:repositorio.unifesp.br/:11600/32302Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-15T10:56:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
title Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
spellingShingle Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
Tomiyama, Cristianne [UNIFESP]
CHRONIC KIDNEY DISEASE
PREDIALYSIS
CORONARY CALCIFICATION
BONE MINERAL METABOLISM
BONE-FORMATION RATE
title_short Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
title_full Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
title_fullStr Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
title_full_unstemmed Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
title_sort Coronary Calcification Is Associated With Lower Bone Formation Rate in CKD Patients Not Yet in Dialysis Treatment
author Tomiyama, Cristianne [UNIFESP]
author_facet Tomiyama, Cristianne [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Higa, Andrea [UNIFESP]
Jorgetti, Vanda
Draibe, Sergio A. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
author_role author
author2 Carvalho, Aluizio B. [UNIFESP]
Higa, Andrea [UNIFESP]
Jorgetti, Vanda
Draibe, Sergio A. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Tomiyama, Cristianne [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Higa, Andrea [UNIFESP]
Jorgetti, Vanda
Draibe, Sergio A. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
dc.subject.por.fl_str_mv CHRONIC KIDNEY DISEASE
PREDIALYSIS
CORONARY CALCIFICATION
BONE MINERAL METABOLISM
BONE-FORMATION RATE
topic CHRONIC KIDNEY DISEASE
PREDIALYSIS
CORONARY CALCIFICATION
BONE MINERAL METABOLISM
BONE-FORMATION RATE
description Vascular calcification is a strong prognostic marker of mortality in hemodialysis patients and has been associated with bone metabolism disorders in this population. in earlier stages of chronic kidney disease (CKD), vascular calcification also has been documented. This study evaluated the association between coronary artery calcification (CAC) and bone histomorphometric parameters in CKD predialysis patients assessed by multislice coronary tomography and by undecalcified bone biopsy. CAC was detected in 33 (66%) patients, and their median calcium score was 89.7 (0.4-2299.3 AU). the most frequent bone histologic alterations observed included low trabecular bone volume, increased eroded and osteoclast surfaces, and low bone-formation rate (BFR/BS). Multiple logistic regression analysis, adjusted for age, sex, and diabetes, showed that BFR/BS was independently associated with the presence of coronary calcification [p=.009; odd ratio (OR) = 0.15; 95% confidence interval (Cl) 0.036-0.619] This study showed a high prevalence of CAC in asymptomatic predialysis CKD patients. Also, there was an independent association of low bone formation and CAC in this population. in conclusion, our results provide evidence that low bone-formation rate constitutes another nontraditional risk factor for cardiovascular disease in CKD patients. 2010 American Society for Bone and Mineral Research.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2016-01-24T13:59:22Z
2016-01-24T13:59:22Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1359/jbmr.090735
Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010.
10.1359/jbmr.090735
0884-0431
http://repositorio.unifesp.br/handle/11600/32302
WOS:000276767700010
url http://dx.doi.org/10.1359/jbmr.090735
http://repositorio.unifesp.br/handle/11600/32302
identifier_str_mv Journal of Bone and Mineral Research. Hoboken: John Wiley & Sons Inc, v. 25, n. 3, p. 499-504, 2010.
10.1359/jbmr.090735
0884-0431
WOS:000276767700010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Bone and Mineral Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 499-504
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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