Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000001cc8 |
DOI: | 10.1161/01.STR.31.11.2719 |
Texto Completo: | http://dx.doi.org/10.1161/01.STR.31.11.2719 http://repositorio.unifesp.br/handle/11600/45634 |
Resumo: | Background-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials. |
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Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhagemannitolrandomized controlled trialsstroke, acutetreatment outcomeBackground-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials.Univ Debrecen, Dept Neurol, H-4012 Debrecen, HungaryW China Univ Med Sci, Dept Neurol, Univ Hosp 1, Chengdu 610041, Sichuan, Peoples R ChinaUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniv DebrecenW China Univ Med SciUniversidade Federal de São Paulo (UNIFESP)Bereczki, DanielLiu, MingPrado, Gilmar Fernandes do [UNIFESP]Fekete, Istvan2018-06-18T12:12:07Z2018-06-18T12:12:07Z2000-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2719-2722http://dx.doi.org/10.1161/01.STR.31.11.2719Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000.10.1161/01.STR.31.11.27190039-2499http://repositorio.unifesp.br/handle/11600/45634WOS:000165107100033ark:/48912/0013000001cc8engStrokeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:22Zoai:repositorio.unifesp.br/:11600/45634Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:50:31.030194Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
title |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
spellingShingle |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage Bereczki, Daniel mannitol randomized controlled trials stroke, acute treatment outcome Bereczki, Daniel mannitol randomized controlled trials stroke, acute treatment outcome |
title_short |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
title_full |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
title_fullStr |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
title_full_unstemmed |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
title_sort |
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage |
author |
Bereczki, Daniel |
author_facet |
Bereczki, Daniel Bereczki, Daniel Liu, Ming Prado, Gilmar Fernandes do [UNIFESP] Fekete, Istvan Liu, Ming Prado, Gilmar Fernandes do [UNIFESP] Fekete, Istvan |
author_role |
author |
author2 |
Liu, Ming Prado, Gilmar Fernandes do [UNIFESP] Fekete, Istvan |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Univ Debrecen W China Univ Med Sci Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Bereczki, Daniel Liu, Ming Prado, Gilmar Fernandes do [UNIFESP] Fekete, Istvan |
dc.subject.por.fl_str_mv |
mannitol randomized controlled trials stroke, acute treatment outcome |
topic |
mannitol randomized controlled trials stroke, acute treatment outcome |
description |
Background-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-11-01 2018-06-18T12:12:07Z 2018-06-18T12:12:07Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1161/01.STR.31.11.2719 Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000. 10.1161/01.STR.31.11.2719 0039-2499 http://repositorio.unifesp.br/handle/11600/45634 WOS:000165107100033 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000001cc8 |
url |
http://dx.doi.org/10.1161/01.STR.31.11.2719 http://repositorio.unifesp.br/handle/11600/45634 |
identifier_str_mv |
Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000. 10.1161/01.STR.31.11.2719 0039-2499 WOS:000165107100033 ark:/48912/0013000001cc8 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Stroke |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2719-2722 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1822252454138347520 |
dc.identifier.doi.none.fl_str_mv |
10.1161/01.STR.31.11.2719 |