Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage

Detalhes bibliográficos
Autor(a) principal: Bereczki, Daniel
Data de Publicação: 2000
Outros Autores: Liu, Ming, Prado, Gilmar Fernandes do [UNIFESP], Fekete, Istvan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000001cc8
DOI: 10.1161/01.STR.31.11.2719
Texto Completo: http://dx.doi.org/10.1161/01.STR.31.11.2719
http://repositorio.unifesp.br/handle/11600/45634
Resumo: Background-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials.
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spelling Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhagemannitolrandomized controlled trialsstroke, acutetreatment outcomeBackground-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials.Univ Debrecen, Dept Neurol, H-4012 Debrecen, HungaryW China Univ Med Sci, Dept Neurol, Univ Hosp 1, Chengdu 610041, Sichuan, Peoples R ChinaUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Internal Med, Sao Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniv DebrecenW China Univ Med SciUniversidade Federal de São Paulo (UNIFESP)Bereczki, DanielLiu, MingPrado, Gilmar Fernandes do [UNIFESP]Fekete, Istvan2018-06-18T12:12:07Z2018-06-18T12:12:07Z2000-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2719-2722http://dx.doi.org/10.1161/01.STR.31.11.2719Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000.10.1161/01.STR.31.11.27190039-2499http://repositorio.unifesp.br/handle/11600/45634WOS:000165107100033ark:/48912/0013000001cc8engStrokeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:22Zoai:repositorio.unifesp.br/:11600/45634Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:50:31.030194Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
title Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
spellingShingle Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
Bereczki, Daniel
mannitol
randomized controlled trials
stroke, acute
treatment outcome
Bereczki, Daniel
mannitol
randomized controlled trials
stroke, acute
treatment outcome
title_short Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
title_full Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
title_fullStr Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
title_full_unstemmed Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
title_sort Cochrane report - A systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage
author Bereczki, Daniel
author_facet Bereczki, Daniel
Bereczki, Daniel
Liu, Ming
Prado, Gilmar Fernandes do [UNIFESP]
Fekete, Istvan
Liu, Ming
Prado, Gilmar Fernandes do [UNIFESP]
Fekete, Istvan
author_role author
author2 Liu, Ming
Prado, Gilmar Fernandes do [UNIFESP]
Fekete, Istvan
author2_role author
author
author
dc.contributor.none.fl_str_mv Univ Debrecen
W China Univ Med Sci
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Bereczki, Daniel
Liu, Ming
Prado, Gilmar Fernandes do [UNIFESP]
Fekete, Istvan
dc.subject.por.fl_str_mv mannitol
randomized controlled trials
stroke, acute
treatment outcome
topic mannitol
randomized controlled trials
stroke, acute
treatment outcome
description Background-Mannitol was reported to decrease cerebral edema associated with tissue damage and is used to treat acute stroke in many countries.Summary of Review-We tested whether there is any evidence from unconfounded randomized clinical trials that treatment with mannitol reduces short- and long-term case fatality and dependency if administered after ischemic stroke or cerebral parenchymal hemorrhage. Trials were identified by the standard search strategy of the Cochrane Collaboration Stroke Review Group. A supplementary MEDLINE search was performed, and the Chinese Stroke Trials Register and the Latin-American databank LILACS were checked. A search was performed of master's and PhD degree theses in the databank of Sao Paulo University and in abstracts of medical congresses on neurology and neurosurgery during 1965-1997 in Brazil. Investigators were contacted for unpublished information. Only truly randomized unconfounded clinical trials were eligible for inclusion. Two of the reviewers independently extracted data from the trials. Data synthesis and analysis was performed with the use of the Cochrane Review Manager software RevMan version 4.0.4).Conclusions-Only 1 trial fulfilled the inclusion criteria. The number of included patients was small, and the follow-up was short. Case fatality, the proportion of dependent patients, and side effects were not reported and were not available from the investigators. As a result of lack of appropriate randomized trials, currently no conclusion can be drawn on the effects of mannitol in acute stroke. The routine use of mannitol in all patients with acute stroke is not supported by evidence from randomized controlled clinical trials.
publishDate 2000
dc.date.none.fl_str_mv 2000-11-01
2018-06-18T12:12:07Z
2018-06-18T12:12:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1161/01.STR.31.11.2719
Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000.
10.1161/01.STR.31.11.2719
0039-2499
http://repositorio.unifesp.br/handle/11600/45634
WOS:000165107100033
dc.identifier.dark.fl_str_mv ark:/48912/0013000001cc8
url http://dx.doi.org/10.1161/01.STR.31.11.2719
http://repositorio.unifesp.br/handle/11600/45634
identifier_str_mv Stroke. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 11, p. 2719-2722, 2000.
10.1161/01.STR.31.11.2719
0039-2499
WOS:000165107100033
ark:/48912/0013000001cc8
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Stroke
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2719-2722
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822252454138347520
dc.identifier.doi.none.fl_str_mv 10.1161/01.STR.31.11.2719