Brazilian flora extracts as source of novel antileishmanial and antifungal compounds
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/4516 http://dx.doi.org/10.1590/S0074-02762008000500006 |
Resumo: | Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis. |
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Tempone, André GustavoSartorelli, Patricia [UNIFESP]Teixeira, DenisePrado, Frederico OCalixto, Ivete ArlLorenzi, HarriMelhem, Márcia ScInstituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia AplicadaUniversidade Federal de São Paulo (UNIFESP)Instituto Plantarum de Estudos da Flora2015-06-14T13:38:41Z2015-06-14T13:38:41Z2008-08-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008.0074-0276http://repositorio.unifesp.br/handle/11600/4516http://dx.doi.org/10.1590/S0074-02762008000500006S0074-02762008000500006.pdfS0074-0276200800050000610.1590/S0074-02762008000500006Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis.Instituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia AplicadaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraInstituto Plantarum de Estudos da FloraUNIFESP, Depto. de Ciências Exatas e da TerraSciELO443-449engInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo CruzLeishmaniaCandidaplantsantimicrobialdrugstherapyBrazilian flora extracts as source of novel antileishmanial and antifungal compoundsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0074-02762008000500006.pdfapplication/pdf424858${dspace.ui.url}/bitstream/11600/4516/1/S0074-02762008000500006.pdf6f314890311ccdb1556471554bed7c25MD51open accessTEXTS0074-02762008000500006.pdf.txtS0074-02762008000500006.pdf.txtExtracted texttext/plain31538${dspace.ui.url}/bitstream/11600/4516/9/S0074-02762008000500006.pdf.txt9e8ce7041d2eb1ad2a75a7cd10b19186MD59open accessTHUMBNAILS0074-02762008000500006.pdf.jpgS0074-02762008000500006.pdf.jpgIM Thumbnailimage/jpeg6503${dspace.ui.url}/bitstream/11600/4516/11/S0074-02762008000500006.pdf.jpge7fc3728c26155fe493edc44dabadc3aMD511open access11600/45162023-06-05 19:30:06.607open accessoai:repositorio.unifesp.br:11600/4516Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:30:06Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
title |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
spellingShingle |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds Tempone, André Gustavo Leishmania Candida plants antimicrobial drugs therapy |
title_short |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
title_full |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
title_fullStr |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
title_full_unstemmed |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
title_sort |
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds |
author |
Tempone, André Gustavo |
author_facet |
Tempone, André Gustavo Sartorelli, Patricia [UNIFESP] Teixeira, Denise Prado, Frederico O Calixto, Ivete Arl Lorenzi, Harri Melhem, Márcia Sc |
author_role |
author |
author2 |
Sartorelli, Patricia [UNIFESP] Teixeira, Denise Prado, Frederico O Calixto, Ivete Arl Lorenzi, Harri Melhem, Márcia Sc |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Instituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia Aplicada Universidade Federal de São Paulo (UNIFESP) Instituto Plantarum de Estudos da Flora |
dc.contributor.author.fl_str_mv |
Tempone, André Gustavo Sartorelli, Patricia [UNIFESP] Teixeira, Denise Prado, Frederico O Calixto, Ivete Arl Lorenzi, Harri Melhem, Márcia Sc |
dc.subject.eng.fl_str_mv |
Leishmania Candida plants antimicrobial drugs therapy |
topic |
Leishmania Candida plants antimicrobial drugs therapy |
description |
Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-08-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:38:41Z |
dc.date.available.fl_str_mv |
2015-06-14T13:38:41Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/4516 http://dx.doi.org/10.1590/S0074-02762008000500006 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.file.none.fl_str_mv |
S0074-02762008000500006.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0074-02762008000500006 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762008000500006 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008. 0074-0276 S0074-02762008000500006.pdf S0074-02762008000500006 10.1590/S0074-02762008000500006 |
url |
http://repositorio.unifesp.br/handle/11600/4516 http://dx.doi.org/10.1590/S0074-02762008000500006 |
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eng |
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Memórias do Instituto Oswaldo Cruz |
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info:eu-repo/semantics/openAccess |
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openAccess |
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443-449 |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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