NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54727 http://dx.doi.org/10.1002/slct.201700009 |
Resumo: | Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users. |
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Tasic, Ljubicade Moraes Pontes, Joao Guilhermede Souza, Rafael NogueiraMarreiro Brasil, Antonio Jadsonde Faria Cruz, Guilherme CrispimAsevedo, ElsonDal Mas, CarolinePoppi, Ronei JesusBrietzke, Elisa [UNIFESP]Furuie Hayashi, Mirian Akemi [UNIFESP]Tavares Lacerda, Acioly Luiz [UNIFESP]2020-07-17T14:02:17Z2020-07-17T14:02:17Z2017Chemistryselect. Weinheim, v. 2, n. 10, p. 2927-2930, 2017.2365-6549https://repositorio.unifesp.br/handle/11600/54727http://dx.doi.org/10.1002/slct.20170000910.1002/slct.201700009WOS:000398582400007Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Univ Estadual Campinas, Chem Inst, Dept Organ Chem, Lab Quim Biol, POB 6154, BR-13083970 Campinas, SP, BrazilUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, BrazilUniv Estadual Campinas, Chem Inst, Dept Analyt Chem, Lab Quimiometria Quim Analit, Campinas, SP, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, BrazilFAPESP: 2014/18938-8CNPq: 454234/2014-7Web of Science2927-2930engWiley-V C H Verlag GmbhChemistryselectcrack-cocainedrug abusemetabolomicsNMR-spectroscopyschizophreniaNMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWeinheim210info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/547272021-09-30 15:49:24.949metadata only accessoai:repositorio.unifesp.br:11600/54727Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-30T18:49:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
title |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
spellingShingle |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes Tasic, Ljubica crack-cocaine drug abuse metabolomics NMR-spectroscopy schizophrenia |
title_short |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
title_full |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
title_fullStr |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
title_full_unstemmed |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
title_sort |
NMR Spectroscopy Metabolomics Applied to Crack Cocaine Users and Patients with Schizophrenia: Similar Behavior but Different Molecular Causes |
author |
Tasic, Ljubica |
author_facet |
Tasic, Ljubica de Moraes Pontes, Joao Guilherme de Souza, Rafael Nogueira Marreiro Brasil, Antonio Jadson de Faria Cruz, Guilherme Crispim Asevedo, Elson Dal Mas, Caroline Poppi, Ronei Jesus Brietzke, Elisa [UNIFESP] Furuie Hayashi, Mirian Akemi [UNIFESP] Tavares Lacerda, Acioly Luiz [UNIFESP] |
author_role |
author |
author2 |
de Moraes Pontes, Joao Guilherme de Souza, Rafael Nogueira Marreiro Brasil, Antonio Jadson de Faria Cruz, Guilherme Crispim Asevedo, Elson Dal Mas, Caroline Poppi, Ronei Jesus Brietzke, Elisa [UNIFESP] Furuie Hayashi, Mirian Akemi [UNIFESP] Tavares Lacerda, Acioly Luiz [UNIFESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tasic, Ljubica de Moraes Pontes, Joao Guilherme de Souza, Rafael Nogueira Marreiro Brasil, Antonio Jadson de Faria Cruz, Guilherme Crispim Asevedo, Elson Dal Mas, Caroline Poppi, Ronei Jesus Brietzke, Elisa [UNIFESP] Furuie Hayashi, Mirian Akemi [UNIFESP] Tavares Lacerda, Acioly Luiz [UNIFESP] |
dc.subject.eng.fl_str_mv |
crack-cocaine drug abuse metabolomics NMR-spectroscopy schizophrenia |
topic |
crack-cocaine drug abuse metabolomics NMR-spectroscopy schizophrenia |
description |
Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-17T14:02:17Z |
dc.date.available.fl_str_mv |
2020-07-17T14:02:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Chemistryselect. Weinheim, v. 2, n. 10, p. 2927-2930, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54727 http://dx.doi.org/10.1002/slct.201700009 |
dc.identifier.issn.none.fl_str_mv |
2365-6549 |
dc.identifier.doi.none.fl_str_mv |
10.1002/slct.201700009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000398582400007 |
identifier_str_mv |
Chemistryselect. Weinheim, v. 2, n. 10, p. 2927-2930, 2017. 2365-6549 10.1002/slct.201700009 WOS:000398582400007 |
url |
https://repositorio.unifesp.br/handle/11600/54727 http://dx.doi.org/10.1002/slct.201700009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Chemistryselect |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2927-2930 |
dc.coverage.none.fl_str_mv |
Weinheim |
dc.publisher.none.fl_str_mv |
Wiley-V C H Verlag Gmbh |
publisher.none.fl_str_mv |
Wiley-V C H Verlag Gmbh |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764174873329664 |