Sleep pattern in an experimental model of chronic kidney disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33095 http://dx.doi.org/10.1152/ajprenal.00118.2010 |
Resumo: | Hirotsu C, Tufik S, Bergamaschi CT, Tenorio NM, Araujo P, Andersen ML. Sleep pattern in an experimental model of chronic kidney disease. Am J Physiol Renal Physiol 299: F1379-F1388, 2010. First published September 8, 2010; doi:10.1152/ajprenal.00118.2010.-The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. the objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. in addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. in the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats. |
id |
UFSP_36cf2f7984faaa7941ea9bd13813cc84 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/33095 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Hirotsu, Camila [UNIFESP]Tufik, Sergio [UNIFESP]Bergamaschi, Cassia Toledo [UNIFESP]Tenorio, Neuli Maria [UNIFESP]Araujo, Paula [UNIFESP]Andersen, Monica Levy [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:05:42Z2016-01-24T14:05:42Z2010-12-01American Journal of Physiology-renal Physiology. Bethesda: Amer Physiological Soc, v. 299, n. 6, p. F1379-F1388, 2010.1931-857Xhttp://repositorio.unifesp.br/handle/11600/33095http://dx.doi.org/10.1152/ajprenal.00118.201010.1152/ajprenal.00118.2010WOS:000285084700018Hirotsu C, Tufik S, Bergamaschi CT, Tenorio NM, Araujo P, Andersen ML. Sleep pattern in an experimental model of chronic kidney disease. Am J Physiol Renal Physiol 299: F1379-F1388, 2010. First published September 8, 2010; doi:10.1152/ajprenal.00118.2010.-The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. the objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. in addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. in the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats.Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)Fundacao de Amparo a Pesquisa do Estado de Sao Paolo (Centros de Pesquisa, Inovacao e Difusao)Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, São Paulo, BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paolo (Centros de Pesquisa, Inovacao e Difusao): 98/14303-3Fundacao de Amparo a Pesquisa do Estado de Sao Paolo (Centros de Pesquisa, Inovacao e Difusao): 2010/50129-1Web of ScienceF1379-F1388engAmer Physiological SocAmerican Journal of Physiology-renal Physiologyrenal diseasesleephypertensioncorticosteronedyslipidemiaelectroencephalogramuremiaSleep pattern in an experimental model of chronic kidney diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/330952023-01-12 21:39:41.127metadata only accessoai:repositorio.unifesp.br:11600/33095Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:09:36.097143Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Sleep pattern in an experimental model of chronic kidney disease |
title |
Sleep pattern in an experimental model of chronic kidney disease |
spellingShingle |
Sleep pattern in an experimental model of chronic kidney disease Hirotsu, Camila [UNIFESP] renal disease sleep hypertension corticosterone dyslipidemia electroencephalogram uremia |
title_short |
Sleep pattern in an experimental model of chronic kidney disease |
title_full |
Sleep pattern in an experimental model of chronic kidney disease |
title_fullStr |
Sleep pattern in an experimental model of chronic kidney disease |
title_full_unstemmed |
Sleep pattern in an experimental model of chronic kidney disease |
title_sort |
Sleep pattern in an experimental model of chronic kidney disease |
author |
Hirotsu, Camila [UNIFESP] |
author_facet |
Hirotsu, Camila [UNIFESP] Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Tenorio, Neuli Maria [UNIFESP] Araujo, Paula [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author_role |
author |
author2 |
Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Tenorio, Neuli Maria [UNIFESP] Araujo, Paula [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Hirotsu, Camila [UNIFESP] Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Tenorio, Neuli Maria [UNIFESP] Araujo, Paula [UNIFESP] Andersen, Monica Levy [UNIFESP] |
dc.subject.eng.fl_str_mv |
renal disease sleep hypertension corticosterone dyslipidemia electroencephalogram uremia |
topic |
renal disease sleep hypertension corticosterone dyslipidemia electroencephalogram uremia |
description |
Hirotsu C, Tufik S, Bergamaschi CT, Tenorio NM, Araujo P, Andersen ML. Sleep pattern in an experimental model of chronic kidney disease. Am J Physiol Renal Physiol 299: F1379-F1388, 2010. First published September 8, 2010; doi:10.1152/ajprenal.00118.2010.-The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. the objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. in addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. in the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-12-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:05:42Z |
dc.date.available.fl_str_mv |
2016-01-24T14:05:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Physiology-renal Physiology. Bethesda: Amer Physiological Soc, v. 299, n. 6, p. F1379-F1388, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33095 http://dx.doi.org/10.1152/ajprenal.00118.2010 |
dc.identifier.issn.none.fl_str_mv |
1931-857X |
dc.identifier.doi.none.fl_str_mv |
10.1152/ajprenal.00118.2010 |
dc.identifier.wos.none.fl_str_mv |
WOS:000285084700018 |
identifier_str_mv |
American Journal of Physiology-renal Physiology. Bethesda: Amer Physiological Soc, v. 299, n. 6, p. F1379-F1388, 2010. 1931-857X 10.1152/ajprenal.00118.2010 WOS:000285084700018 |
url |
http://repositorio.unifesp.br/handle/11600/33095 http://dx.doi.org/10.1152/ajprenal.00118.2010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Physiology-renal Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
F1379-F1388 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460257106755584 |