Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis

• Autor(a) principal: McNeill, Alisdair
• Data de Publicação: 2013
• Outros Autores: Wu, Ruey-Meei, Tzen, Kai-Yuan, Aguiar, Patricia C., Arbelo, Jose M., Barone, Paolo, Bhatia, Kailash, Barsottini, Orlando [UNIFESP], Bonifati, Vincenzo, Bostantjopoulou, Sevasti, Bressan, Rodrigo, Cossu, Giovanni, Cortelli, Pietro, Felicio, Andre, Ferraz, Henrique B. [UNIFESP], Herrera, Joanna, Houlden, Henry, Hoexter, Marcelo, Isla, Concepcion, Lees, Andrew, Lorenzo-Betancor, Oswaldo, Mencacci, Niccolo E., Pastor, Pau, Pappata, Sabina, Pellecchia, Maria Teresa, Silveria-Moriyama, Laura, Varrone, Andrea, Foltynie, Tom, Schapira, Anthony H. V.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/36546; http://dx.doi.org/10.1371/journal.pone.0069190

Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. the right: left asymmetry index and striatal asymmetry index was calculated.Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). the asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions: the asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.