Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/30750 http://dx.doi.org/10.2119/2007-00112.Fernandes |
Resumo: | The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 mu M compared with 12.7 +/- 1.5 mu M, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension, Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia. |
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Fernandes, Fernanda B. [UNIFESP]Plavnik, Frida L. [UNIFESP]Teixeira, Andressa M. S. [UNIFESP]Christofalo, Dejaldo M. J. [UNIFESP]Ajzen, Sergio A. [UNIFESP]Higa, Elisa M. S. [UNIFESP]Ronchi, Fernanda A. [UNIFESP]Sesso, Ricardo C. C. [UNIFESP]Casarini, Dulce E. [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T13:51:30Z2016-01-24T13:51:30Z2008-07-01Molecular Medicine. Manhasset: Feinstein Inst Med Res, v. 14, n. 7-8, p. 429-435, 2008.1076-1551http://repositorio.unifesp.br/handle/11600/30750http://dx.doi.org/10.2119/2007-00112.Fernandes10.2119/2007-00112.FernandesWOS:000257727000009The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 mu M compared with 12.7 +/- 1.5 mu M, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension, Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia.Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Image Diagnost, São Paulo, BrazilUniversidade Federal de São Paulo, Oswaldo Ramos Fdn, São Paulo, BrazilUniversidade Federal de São Paulo, Emergency Div, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Image Diagnost, São Paulo, BrazilUniversidade Federal de São Paulo, Oswaldo Ramos Fdn, São Paulo, BrazilUniversidade Federal de São Paulo, Emergency Div, São Paulo, BrazilWeb of Science429-435engFeinstein Inst Med ResMolecular MedicineAssociation of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial functioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/307502023-01-12 22:03:33.686metadata only accessoai:repositorio.unifesp.br:11600/30750Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-13T01:03:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
title |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
spellingShingle |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function Fernandes, Fernanda B. [UNIFESP] |
title_short |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
title_full |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
title_fullStr |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
title_full_unstemmed |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
title_sort |
Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function |
author |
Fernandes, Fernanda B. [UNIFESP] |
author_facet |
Fernandes, Fernanda B. [UNIFESP] Plavnik, Frida L. [UNIFESP] Teixeira, Andressa M. S. [UNIFESP] Christofalo, Dejaldo M. J. [UNIFESP] Ajzen, Sergio A. [UNIFESP] Higa, Elisa M. S. [UNIFESP] Ronchi, Fernanda A. [UNIFESP] Sesso, Ricardo C. C. [UNIFESP] Casarini, Dulce E. [UNIFESP] |
author_role |
author |
author2 |
Plavnik, Frida L. [UNIFESP] Teixeira, Andressa M. S. [UNIFESP] Christofalo, Dejaldo M. J. [UNIFESP] Ajzen, Sergio A. [UNIFESP] Higa, Elisa M. S. [UNIFESP] Ronchi, Fernanda A. [UNIFESP] Sesso, Ricardo C. C. [UNIFESP] Casarini, Dulce E. [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Fernandes, Fernanda B. [UNIFESP] Plavnik, Frida L. [UNIFESP] Teixeira, Andressa M. S. [UNIFESP] Christofalo, Dejaldo M. J. [UNIFESP] Ajzen, Sergio A. [UNIFESP] Higa, Elisa M. S. [UNIFESP] Ronchi, Fernanda A. [UNIFESP] Sesso, Ricardo C. C. [UNIFESP] Casarini, Dulce E. [UNIFESP] |
description |
The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 mu M compared with 12.7 +/- 1.5 mu M, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension, Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-07-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:51:30Z |
dc.date.available.fl_str_mv |
2016-01-24T13:51:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Molecular Medicine. Manhasset: Feinstein Inst Med Res, v. 14, n. 7-8, p. 429-435, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/30750 http://dx.doi.org/10.2119/2007-00112.Fernandes |
dc.identifier.issn.none.fl_str_mv |
1076-1551 |
dc.identifier.doi.none.fl_str_mv |
10.2119/2007-00112.Fernandes |
dc.identifier.wos.none.fl_str_mv |
WOS:000257727000009 |
identifier_str_mv |
Molecular Medicine. Manhasset: Feinstein Inst Med Res, v. 14, n. 7-8, p. 429-435, 2008. 1076-1551 10.2119/2007-00112.Fernandes WOS:000257727000009 |
url |
http://repositorio.unifesp.br/handle/11600/30750 http://dx.doi.org/10.2119/2007-00112.Fernandes |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Molecular Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
429-435 |
dc.publisher.none.fl_str_mv |
Feinstein Inst Med Res |
publisher.none.fl_str_mv |
Feinstein Inst Med Res |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764121925484544 |