Thrombocytemia as a predictor of portal hypertension in schistosomiasis
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43492 http://dx.doi.org/10.1023/A:1005535808464 |
Resumo: | Sufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma -glutamyltransferase, serum alpha (2)-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included. |
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Souza, Marilia Rodrigues Freitas de [UNIFESP]Toledo, Carlos Fischer de [UNIFESP]Borges, Durval Rosa [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T17:17:24Z2018-06-15T17:17:24Z2000-10-01Digestive Diseases And Sciences. Dordrecht: Springer, v. 45, n. 10, p. 1964-1970, 2000.0163-2116http://repositorio.unifesp.br/11600/43492http://dx.doi.org/10.1023/A:100553580846410.1023/A:1005535808464WOS:000165435500011Sufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma -glutamyltransferase, serum alpha (2)-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included.Univ Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, Div Gastroenterol, Sao Paulo, BrazilWeb of Science1964-1970engSpringerDigestive Diseases And Scienceshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0info:eu-repo/semantics/openAccessplateletsschistosomiasisportal hypertensionhypersplenismThrombocytemia as a predictor of portal hypertension in schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/434922021-10-04 21:23:54.948metadata only accessoai:repositorio.unifesp.br:11600/43492Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-05T00:23:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
title |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
spellingShingle |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis Souza, Marilia Rodrigues Freitas de [UNIFESP] platelets schistosomiasis portal hypertension hypersplenism |
title_short |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
title_full |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
title_fullStr |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
title_full_unstemmed |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
title_sort |
Thrombocytemia as a predictor of portal hypertension in schistosomiasis |
author |
Souza, Marilia Rodrigues Freitas de [UNIFESP] |
author_facet |
Souza, Marilia Rodrigues Freitas de [UNIFESP] Toledo, Carlos Fischer de [UNIFESP] Borges, Durval Rosa [UNIFESP] |
author_role |
author |
author2 |
Toledo, Carlos Fischer de [UNIFESP] Borges, Durval Rosa [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Souza, Marilia Rodrigues Freitas de [UNIFESP] Toledo, Carlos Fischer de [UNIFESP] Borges, Durval Rosa [UNIFESP] |
dc.subject.eng.fl_str_mv |
platelets schistosomiasis portal hypertension hypersplenism |
topic |
platelets schistosomiasis portal hypertension hypersplenism |
description |
Sufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma -glutamyltransferase, serum alpha (2)-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-10-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T17:17:24Z |
dc.date.available.fl_str_mv |
2018-06-15T17:17:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Digestive Diseases And Sciences. Dordrecht: Springer, v. 45, n. 10, p. 1964-1970, 2000. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43492 http://dx.doi.org/10.1023/A:1005535808464 |
dc.identifier.issn.none.fl_str_mv |
0163-2116 |
dc.identifier.doi.none.fl_str_mv |
10.1023/A:1005535808464 |
dc.identifier.wos.none.fl_str_mv |
WOS:000165435500011 |
identifier_str_mv |
Digestive Diseases And Sciences. Dordrecht: Springer, v. 45, n. 10, p. 1964-1970, 2000. 0163-2116 10.1023/A:1005535808464 WOS:000165435500011 |
url |
http://repositorio.unifesp.br/11600/43492 http://dx.doi.org/10.1023/A:1005535808464 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Digestive Diseases And Sciences |
dc.rights.driver.fl_str_mv |
http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1964-1970 |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764137008201728 |