Natural antibodies in paracoccidioidomycosis

Detalhes bibliográficos
Autor(a) principal: Unterkircher, Carmelinda Schmidt [UNIFESP]
Data de Publicação: 2004
Outros Autores: Leão, Mariella V.p., Blotta, Maria Heloisa S.l., Camargo, Zoilo Pires de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1517-83822004000100009
http://repositorio.unifesp.br/handle/11600/2150
Resumo: Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.
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spelling Natural antibodies in paracoccidioidomycosisAnticorpos naturais na paracoccidioidomicoseNatural antibodiesParacoccidioides brasiliensisParacoccidioidomycosisAnticorpos naturaisParacoccidioides brasiliensisParacoccidiodomicoseRecent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.Recente atenção tem sido dada aos anticorpos naturais como componentes da imunidade natural e como parte integrante da rede idiotípica. Todavia, seu papel funcional em diferentes infecções tem, raramente, sido estudado. O objetivo deste trabalho foi investigar a presença de anticorpos naturais na paracoccidioidomicose (PCM). Em adição, analisamos os anticorpos específicos anti-P. brasiliensis e sua distribuição em subclasses a fim de adquirir mais conhecimento sobre a resposta imune humoral nesta micose. Nossos achados mostram que a resposta de anticorpos naturais não é acentuada na PCM quando comparada com outras infecções por parasitas e, é restrita a poucas especificidades, sugerindo que o P. brasiliensis estimula moderadamente as células B CD5+. O anticorpo anti-actina foi a principal especificidade encontrada na PCM. Os anticorpos especificos para P. brasiliensis, nos pacientes crônicos, eram, principalmente, da subclasse IgG1.Universidade Estadual Paulista Faculdade de Odontologia Departamento de Biociências e Diagnóstico BucalUniversidade de Taubaté Departamento de MedicinaUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de Patologia ClínicaEscola Paulista de Medicina Disciplina de Biologia CelularUNIFESP, EPM, Disciplina de Biologia CelularSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sociedade Brasileira de MicrobiologiaUniversidade Estadual Paulista (UNESP)Universidade de Taubaté Departamento de MedicinaUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)Unterkircher, Carmelinda Schmidt [UNIFESP]Leão, Mariella V.p.Blotta, Maria Heloisa S.l.Camargo, Zoilo Pires de [UNIFESP]2015-06-14T13:31:11Z2015-06-14T13:31:11Z2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion59-63application/pdfhttp://dx.doi.org/10.1590/S1517-83822004000100009Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 35, n. 1-2, p. 59-63, 2004.10.1590/S1517-83822004000100009S1517-83822004000100009.pdf1517-8382S1517-83822004000100009http://repositorio.unifesp.br/handle/11600/2150WOS:000234802500009engBrazilian Journal of Microbiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T02:04:58Zoai:repositorio.unifesp.br/:11600/2150Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T02:04:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Natural antibodies in paracoccidioidomycosis
Anticorpos naturais na paracoccidioidomicose
title Natural antibodies in paracoccidioidomycosis
spellingShingle Natural antibodies in paracoccidioidomycosis
Unterkircher, Carmelinda Schmidt [UNIFESP]
Natural antibodies
Paracoccidioides brasiliensis
Paracoccidioidomycosis
Anticorpos naturais
Paracoccidioides brasiliensis
Paracoccidiodomicose
title_short Natural antibodies in paracoccidioidomycosis
title_full Natural antibodies in paracoccidioidomycosis
title_fullStr Natural antibodies in paracoccidioidomycosis
title_full_unstemmed Natural antibodies in paracoccidioidomycosis
title_sort Natural antibodies in paracoccidioidomycosis
author Unterkircher, Carmelinda Schmidt [UNIFESP]
author_facet Unterkircher, Carmelinda Schmidt [UNIFESP]
Leão, Mariella V.p.
Blotta, Maria Heloisa S.l.
Camargo, Zoilo Pires de [UNIFESP]
author_role author
author2 Leão, Mariella V.p.
Blotta, Maria Heloisa S.l.
Camargo, Zoilo Pires de [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de Taubaté Departamento de Medicina
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Unterkircher, Carmelinda Schmidt [UNIFESP]
Leão, Mariella V.p.
Blotta, Maria Heloisa S.l.
Camargo, Zoilo Pires de [UNIFESP]
dc.subject.por.fl_str_mv Natural antibodies
Paracoccidioides brasiliensis
Paracoccidioidomycosis
Anticorpos naturais
Paracoccidioides brasiliensis
Paracoccidiodomicose
topic Natural antibodies
Paracoccidioides brasiliensis
Paracoccidioidomycosis
Anticorpos naturais
Paracoccidioides brasiliensis
Paracoccidiodomicose
description Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied. This work was undertaken to investigate the presence of natural antibodies in paracoccidioidomycosis (PCM). In addition, we analyzed anti-P. brasiliensis antibodies and their distribution in IgG subclasses in order to acquire better knowledge about the humoral immune response in this mycosis. Our findings show that the natural antibody response is not very much increased in PCM when compared with other parasite infections and this response is restricted to a few specificities, suggesting that P. brasiliensis moderately triggers CD5+ B cells. The anti-actin antibody was the main antibody specificity found in PCM. Specific antibodies to P. brasiliensis were mainly found in the IgG1 subclass in chronic patients of PCM.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
2015-06-14T13:31:11Z
2015-06-14T13:31:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1517-83822004000100009
Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 35, n. 1-2, p. 59-63, 2004.
10.1590/S1517-83822004000100009
S1517-83822004000100009.pdf
1517-8382
S1517-83822004000100009
http://repositorio.unifesp.br/handle/11600/2150
WOS:000234802500009
url http://dx.doi.org/10.1590/S1517-83822004000100009
http://repositorio.unifesp.br/handle/11600/2150
identifier_str_mv Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 35, n. 1-2, p. 59-63, 2004.
10.1590/S1517-83822004000100009
S1517-83822004000100009.pdf
1517-8382
S1517-83822004000100009
WOS:000234802500009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Microbiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 59-63
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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