Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

• Autor(a) principal: Lira, Fabio Santos de [UNIFESP]
• Data de Publicação: 2012
• Outros Autores: Rosa Neto, José Cesar [UNIFESP], Pimentel, Gustavo Duarte [UNIFESP], Santos, Ronaldo Vagner Thomatieli dos [UNIFESP], Carnier, June [UNIFESP], Sanches, Priscila de Lima [UNIFESP], Piano, Aline de [UNIFESP], Souza, Claudio T. de, Tock, Lian [UNIFESP], Tufik, Sergio [UNIFESP], Mello, Marco Tulio de [UNIFESP], Seelaender, Marilia Cerqueira Leite [UNIFESP], Nascimento, Claudia Maria da Penha Oller do [UNIFESP], Oyama, Lila Missae [UNIFESP], Dâmaso, Ana Raimunda [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/0013000005q2r
• DOI: 10.1186/1475-2891-11-74
• Texto Completo: https://dx.doi.org/10.1186/1475-2891-11-74; https://repositorio.unifesp.br/handle/11600/35277
• topic: Obesity; Cytokines; Endotoxin; Insulin resistance; Interdisciplinary therapy

Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.