Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0102-695X2011005000219 http://repositorio.unifesp.br/handle/11600/7037 |
Resumo: | Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5). |
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Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianusacetylcholinesterase inhibitors, alkaloidsConchocarpus fontanesianuscoumarin RutaceaeConchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).Instituto de Botânica de São Paulo Núcleo de Pesquisa em Fisiologia e BioquímicaInstituto de Botânica de São Paulo Núcleo de Pesquisa Curadoria do Herbário São PauloUniversidade Estadual de Campinas Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e AgrícolasUniversidade Estadual de Campinas Laboratório Thomson Espectrometria de MassaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraUniversidade de São Paulo Instituto de QuímicaUNIFESP, Depto. de Ciências Exatas e da TerraSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sociedade Brasileira de FarmacognosiaInstituto de Botânica de São Paulo Núcleo de Pesquisa em Fisiologia e BioquímicaInstituto de Botânica de São Paulo Núcleo de Pesquisa Curadoria do Herbário São PauloUniversidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Cabral, Rodrigo Sant'AnaSartori, Maura CasariCordeiro, InêsQueiroga, Carmen LuciaEberlin, Marcos NogueiraLago, Joao Henrique Ghilardi [UNIFESP]Moreno, Paulo Roberto HrihorowitschYoung, Maria Claudia Marx2015-06-14T13:43:41Z2015-06-14T13:43:41Z2012-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion374-380application/pdfhttp://dx.doi.org/10.1590/S0102-695X2011005000219Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 374-380, 2012.10.1590/S0102-695X2011005000219S0102-695X2012000200018.pdf0102-695XS0102-695X2012000200018http://repositorio.unifesp.br/handle/11600/7037WOS:000299742200018engRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T19:36:24Zoai:repositorio.unifesp.br/:11600/7037Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T19:36:24Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| spellingShingle |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus Cabral, Rodrigo Sant'Ana acetylcholinesterase inhibitors, alkaloids Conchocarpus fontanesianus coumarin Rutaceae |
| title_short |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_full |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_fullStr |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_full_unstemmed |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_sort |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| author |
Cabral, Rodrigo Sant'Ana |
| author_facet |
Cabral, Rodrigo Sant'Ana Sartori, Maura Casari Cordeiro, Inês Queiroga, Carmen Lucia Eberlin, Marcos Nogueira Lago, Joao Henrique Ghilardi [UNIFESP] Moreno, Paulo Roberto Hrihorowitsch Young, Maria Claudia Marx |
| author_role |
author |
| author2 |
Sartori, Maura Casari Cordeiro, Inês Queiroga, Carmen Lucia Eberlin, Marcos Nogueira Lago, Joao Henrique Ghilardi [UNIFESP] Moreno, Paulo Roberto Hrihorowitsch Young, Maria Claudia Marx |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Botânica de São Paulo Núcleo de Pesquisa em Fisiologia e Bioquímica Instituto de Botânica de São Paulo Núcleo de Pesquisa Curadoria do Herbário São Paulo Universidade Estadual de Campinas (UNICAMP) Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
| dc.contributor.author.fl_str_mv |
Cabral, Rodrigo Sant'Ana Sartori, Maura Casari Cordeiro, Inês Queiroga, Carmen Lucia Eberlin, Marcos Nogueira Lago, Joao Henrique Ghilardi [UNIFESP] Moreno, Paulo Roberto Hrihorowitsch Young, Maria Claudia Marx |
| dc.subject.por.fl_str_mv |
acetylcholinesterase inhibitors, alkaloids Conchocarpus fontanesianus coumarin Rutaceae |
| topic |
acetylcholinesterase inhibitors, alkaloids Conchocarpus fontanesianus coumarin Rutaceae |
| description |
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5). |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-04-01 2015-06-14T13:43:41Z 2015-06-14T13:43:41Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-695X2011005000219 Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 374-380, 2012. 10.1590/S0102-695X2011005000219 S0102-695X2012000200018.pdf 0102-695X S0102-695X2012000200018 http://repositorio.unifesp.br/handle/11600/7037 WOS:000299742200018 |
| url |
http://dx.doi.org/10.1590/S0102-695X2011005000219 http://repositorio.unifesp.br/handle/11600/7037 |
| identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 374-380, 2012. 10.1590/S0102-695X2011005000219 S0102-695X2012000200018.pdf 0102-695X S0102-695X2012000200018 WOS:000299742200018 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista Brasileira de Farmacognosia |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
374-380 application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268414196187136 |