Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Detalhes bibliográficos
Autor(a) principal: Cardoso-Lopes, Elaine Monteiro
Data de Publicação: 2010
Outros Autores: Maier, James Andreas, da Silva, Marcelo Rogerio, Ragasini, Luis Octavio [UNESP], Simote, Simone Yasue [UNESP], Lopes, Norberto Peporine, Pirani, Jose Rubens, Bolzani, Vanderlan da Silva [UNESP], Marx Young, Maria Claudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/molecules15129205
http://hdl.handle.net/11449/26167
Resumo: Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
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spelling Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer DiseaseEsenbeckia leiocarpaRutaceaealkaloidsacetylcholinesterase inhibitorsEsenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Inst Bot, Sect Plant Physiol & Biochem, BR-01061970 São Paulo, BrazilSão Paulo State Univ, Inst Chem, BR-14801970 Araraquara, SP, BrazilUniv São Paulo, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP, BrazilUniv São Paulo, Dept Bot, Biosci Inst, BR-05422970 São Paulo, BrazilSão Paulo State Univ, Inst Chem, BR-14801970 Araraquara, SP, BrazilFAPESP: 03/02176-7Mdpi AgInst BotUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Cardoso-Lopes, Elaine MonteiroMaier, James Andreasda Silva, Marcelo RogerioRagasini, Luis Octavio [UNESP]Simote, Simone Yasue [UNESP]Lopes, Norberto PeporinePirani, Jose RubensBolzani, Vanderlan da Silva [UNESP]Marx Young, Maria Claudia2014-05-20T14:20:32Z2014-05-20T14:20:32Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9205-9213application/pdfhttp://dx.doi.org/10.3390/molecules15129205Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010.1420-3049http://hdl.handle.net/11449/2616710.3390/molecules15129205WOS:000285709000045WOS000285709000045.pdf4484083685251673Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules3.0980,855info:eu-repo/semantics/openAccess2023-10-23T06:04:39Zoai:repositorio.unesp.br:11449/26167Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:40:46.479028Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
title Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
spellingShingle Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
Cardoso-Lopes, Elaine Monteiro
Esenbeckia leiocarpa
Rutaceae
alkaloids
acetylcholinesterase inhibitors
title_short Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
title_full Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
title_fullStr Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
title_full_unstemmed Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
title_sort Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
author Cardoso-Lopes, Elaine Monteiro
author_facet Cardoso-Lopes, Elaine Monteiro
Maier, James Andreas
da Silva, Marcelo Rogerio
Ragasini, Luis Octavio [UNESP]
Simote, Simone Yasue [UNESP]
Lopes, Norberto Peporine
Pirani, Jose Rubens
Bolzani, Vanderlan da Silva [UNESP]
Marx Young, Maria Claudia
author_role author
author2 Maier, James Andreas
da Silva, Marcelo Rogerio
Ragasini, Luis Octavio [UNESP]
Simote, Simone Yasue [UNESP]
Lopes, Norberto Peporine
Pirani, Jose Rubens
Bolzani, Vanderlan da Silva [UNESP]
Marx Young, Maria Claudia
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Inst Bot
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Cardoso-Lopes, Elaine Monteiro
Maier, James Andreas
da Silva, Marcelo Rogerio
Ragasini, Luis Octavio [UNESP]
Simote, Simone Yasue [UNESP]
Lopes, Norberto Peporine
Pirani, Jose Rubens
Bolzani, Vanderlan da Silva [UNESP]
Marx Young, Maria Claudia
dc.subject.por.fl_str_mv Esenbeckia leiocarpa
Rutaceae
alkaloids
acetylcholinesterase inhibitors
topic Esenbeckia leiocarpa
Rutaceae
alkaloids
acetylcholinesterase inhibitors
description Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
2014-05-20T14:20:32Z
2014-05-20T14:20:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/molecules15129205
Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010.
1420-3049
http://hdl.handle.net/11449/26167
10.3390/molecules15129205
WOS:000285709000045
WOS000285709000045.pdf
4484083685251673
url http://dx.doi.org/10.3390/molecules15129205
http://hdl.handle.net/11449/26167
identifier_str_mv Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010.
1420-3049
10.3390/molecules15129205
WOS:000285709000045
WOS000285709000045.pdf
4484083685251673
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molecules
3.098
0,855
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9205-9213
application/pdf
dc.publisher.none.fl_str_mv Mdpi Ag
publisher.none.fl_str_mv Mdpi Ag
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
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repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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