Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/molecules15129205 http://hdl.handle.net/11449/26167 |
Resumo: | Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. |
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Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer DiseaseEsenbeckia leiocarpaRutaceaealkaloidsacetylcholinesterase inhibitorsEsenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Inst Bot, Sect Plant Physiol & Biochem, BR-01061970 São Paulo, BrazilSão Paulo State Univ, Inst Chem, BR-14801970 Araraquara, SP, BrazilUniv São Paulo, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP, BrazilUniv São Paulo, Dept Bot, Biosci Inst, BR-05422970 São Paulo, BrazilSão Paulo State Univ, Inst Chem, BR-14801970 Araraquara, SP, BrazilFAPESP: 03/02176-7Mdpi AgInst BotUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Cardoso-Lopes, Elaine MonteiroMaier, James Andreasda Silva, Marcelo RogerioRagasini, Luis Octavio [UNESP]Simote, Simone Yasue [UNESP]Lopes, Norberto PeporinePirani, Jose RubensBolzani, Vanderlan da Silva [UNESP]Marx Young, Maria Claudia2014-05-20T14:20:32Z2014-05-20T14:20:32Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9205-9213application/pdfhttp://dx.doi.org/10.3390/molecules15129205Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010.1420-3049http://hdl.handle.net/11449/2616710.3390/molecules15129205WOS:000285709000045WOS000285709000045.pdf4484083685251673Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules3.0980,855info:eu-repo/semantics/openAccess2023-10-23T06:04:39Zoai:repositorio.unesp.br:11449/26167Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:40:46.479028Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
title |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
spellingShingle |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease Cardoso-Lopes, Elaine Monteiro Esenbeckia leiocarpa Rutaceae alkaloids acetylcholinesterase inhibitors |
title_short |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
title_full |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
title_fullStr |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
title_full_unstemmed |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
title_sort |
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease |
author |
Cardoso-Lopes, Elaine Monteiro |
author_facet |
Cardoso-Lopes, Elaine Monteiro Maier, James Andreas da Silva, Marcelo Rogerio Ragasini, Luis Octavio [UNESP] Simote, Simone Yasue [UNESP] Lopes, Norberto Peporine Pirani, Jose Rubens Bolzani, Vanderlan da Silva [UNESP] Marx Young, Maria Claudia |
author_role |
author |
author2 |
Maier, James Andreas da Silva, Marcelo Rogerio Ragasini, Luis Octavio [UNESP] Simote, Simone Yasue [UNESP] Lopes, Norberto Peporine Pirani, Jose Rubens Bolzani, Vanderlan da Silva [UNESP] Marx Young, Maria Claudia |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Inst Bot Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Cardoso-Lopes, Elaine Monteiro Maier, James Andreas da Silva, Marcelo Rogerio Ragasini, Luis Octavio [UNESP] Simote, Simone Yasue [UNESP] Lopes, Norberto Peporine Pirani, Jose Rubens Bolzani, Vanderlan da Silva [UNESP] Marx Young, Maria Claudia |
dc.subject.por.fl_str_mv |
Esenbeckia leiocarpa Rutaceae alkaloids acetylcholinesterase inhibitors |
topic |
Esenbeckia leiocarpa Rutaceae alkaloids acetylcholinesterase inhibitors |
description |
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC(50) = 2.5 mu M), similar to that of the reference compound galanthamine (IC(50) = 1.7 mu M). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2014-05-20T14:20:32Z 2014-05-20T14:20:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/molecules15129205 Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010. 1420-3049 http://hdl.handle.net/11449/26167 10.3390/molecules15129205 WOS:000285709000045 WOS000285709000045.pdf 4484083685251673 |
url |
http://dx.doi.org/10.3390/molecules15129205 http://hdl.handle.net/11449/26167 |
identifier_str_mv |
Molecules. Basel: Mdpi Ag, v. 15, n. 12, p. 9205-9213, 2010. 1420-3049 10.3390/molecules15129205 WOS:000285709000045 WOS000285709000045.pdf 4484083685251673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecules 3.098 0,855 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9205-9213 application/pdf |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128548838309888 |