Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism

Detalhes bibliográficos
Autor(a) principal: Maciel, Lea Maria Zanini
Data de Publicação: 2013
Outros Autores: Kimura, Edna Teruko [UNIFESP], Nogueira, Celia Regina, Mazeto, Glaucia M. F. S., Magalhaes, Patricia Kuenzle Ribeiro, Nascimento, Marilza Leal, Nesi-Franca, Suzana, Vieira, Sandra Elisabete
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302013000300004
http://repositorio.unifesp.br/handle/11600/42712
Resumo: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum.
id UFSP_426a36f8443ed328394d73e4b56d71c1
oai_identifier_str oai:repositorio.unifesp.br/:11600/42712
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and MetabolismHipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e MetabologiaCongenital hypothyroidismneonatal screeningCongenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum.Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Div Endocrinol & Metabol, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Inst Ciencias Biomed, BR-09500900 Sao Paulo, BrazilUniv Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Clin Med, Div Endocrinol & Metabol, Botucatu, SP, BrazilUniv Fed Santa Catarina, Florianopolis, SC, BrazilUniv Fed Parana UFPR, Dept Pediat, Unidade Endocrinol Pediat, Curitiba, Parana, BrazilUniv Sao Paulo FMUSP, Fac Med, Dept Pediat, Sao Paulo, SP, BrazilWeb of ScienceSbem-soc Brasil Endocrinologia & MetabologiaUniversidade de São Paulo (USP)Universidade Federal de Santa Catarina (UFSC)Universidade Federal do Paraná (UFPR)Universidade Federal de São Paulo (UNIFESP)Maciel, Lea Maria ZaniniKimura, Edna Teruko [UNIFESP]Nogueira, Celia ReginaMazeto, Glaucia M. F. S.Magalhaes, Patricia Kuenzle RibeiroNascimento, Marilza LealNesi-Franca, SuzanaVieira, Sandra Elisabete2018-06-15T14:00:11Z2018-06-15T14:00:11Z2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion184-192http://dx.doi.org/10.1590/S0004-27302013000300004Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013.10.1590/S0004-27302013000300004S0004-27302013000300004-en.pdfS0004-27302013000300004-pt.pdf0004-2730S0004-27302013000300004http://repositorio.unifesp.br/handle/11600/42712WOS:000319993400004porArquivos Brasileiros De Endocrinologia E Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:31Zoai:repositorio.unifesp.br/:11600/42712Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:59:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
Hipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia
title Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
spellingShingle Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
Maciel, Lea Maria Zanini
Congenital hypothyroidism
neonatal screening
title_short Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
title_full Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
title_fullStr Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
title_full_unstemmed Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
title_sort Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
author Maciel, Lea Maria Zanini
author_facet Maciel, Lea Maria Zanini
Kimura, Edna Teruko [UNIFESP]
Nogueira, Celia Regina
Mazeto, Glaucia M. F. S.
Magalhaes, Patricia Kuenzle Ribeiro
Nascimento, Marilza Leal
Nesi-Franca, Suzana
Vieira, Sandra Elisabete
author_role author
author2 Kimura, Edna Teruko [UNIFESP]
Nogueira, Celia Regina
Mazeto, Glaucia M. F. S.
Magalhaes, Patricia Kuenzle Ribeiro
Nascimento, Marilza Leal
Nesi-Franca, Suzana
Vieira, Sandra Elisabete
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de Santa Catarina (UFSC)
Universidade Federal do Paraná (UFPR)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Maciel, Lea Maria Zanini
Kimura, Edna Teruko [UNIFESP]
Nogueira, Celia Regina
Mazeto, Glaucia M. F. S.
Magalhaes, Patricia Kuenzle Ribeiro
Nascimento, Marilza Leal
Nesi-Franca, Suzana
Vieira, Sandra Elisabete
dc.subject.por.fl_str_mv Congenital hypothyroidism
neonatal screening
topic Congenital hypothyroidism
neonatal screening
description Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
2018-06-15T14:00:11Z
2018-06-15T14:00:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302013000300004
Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013.
10.1590/S0004-27302013000300004
S0004-27302013000300004-en.pdf
S0004-27302013000300004-pt.pdf
0004-2730
S0004-27302013000300004
http://repositorio.unifesp.br/handle/11600/42712
WOS:000319993400004
url http://dx.doi.org/10.1590/S0004-27302013000300004
http://repositorio.unifesp.br/handle/11600/42712
identifier_str_mv Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013.
10.1590/S0004-27302013000300004
S0004-27302013000300004-en.pdf
S0004-27302013000300004-pt.pdf
0004-2730
S0004-27302013000300004
WOS:000319993400004
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros De Endocrinologia E Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 184-192
dc.publisher.none.fl_str_mv Sbem-soc Brasil Endocrinologia & Metabologia
publisher.none.fl_str_mv Sbem-soc Brasil Endocrinologia & Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268348553232384