Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-27302013000300004 http://repositorio.unifesp.br/handle/11600/42712 |
Resumo: | Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum. |
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Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and MetabolismHipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e MetabologiaCongenital hypothyroidismneonatal screeningCongenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum.Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Div Endocrinol & Metabol, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Inst Ciencias Biomed, BR-09500900 Sao Paulo, BrazilUniv Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Clin Med, Div Endocrinol & Metabol, Botucatu, SP, BrazilUniv Fed Santa Catarina, Florianopolis, SC, BrazilUniv Fed Parana UFPR, Dept Pediat, Unidade Endocrinol Pediat, Curitiba, Parana, BrazilUniv Sao Paulo FMUSP, Fac Med, Dept Pediat, Sao Paulo, SP, BrazilWeb of ScienceSbem-soc Brasil Endocrinologia & MetabologiaUniversidade de São Paulo (USP)Universidade Federal de Santa Catarina (UFSC)Universidade Federal do Paraná (UFPR)Universidade Federal de São Paulo (UNIFESP)Maciel, Lea Maria ZaniniKimura, Edna Teruko [UNIFESP]Nogueira, Celia ReginaMazeto, Glaucia M. F. S.Magalhaes, Patricia Kuenzle RibeiroNascimento, Marilza LealNesi-Franca, SuzanaVieira, Sandra Elisabete2018-06-15T14:00:11Z2018-06-15T14:00:11Z2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion184-192http://dx.doi.org/10.1590/S0004-27302013000300004Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013.10.1590/S0004-27302013000300004S0004-27302013000300004-en.pdfS0004-27302013000300004-pt.pdf0004-2730S0004-27302013000300004http://repositorio.unifesp.br/handle/11600/42712WOS:000319993400004porArquivos Brasileiros De Endocrinologia E Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:59:31Zoai:repositorio.unifesp.br/:11600/42712Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:59:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism Hipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia |
title |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
spellingShingle |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism Maciel, Lea Maria Zanini Congenital hypothyroidism neonatal screening |
title_short |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
title_full |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
title_fullStr |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
title_full_unstemmed |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
title_sort |
Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism |
author |
Maciel, Lea Maria Zanini |
author_facet |
Maciel, Lea Maria Zanini Kimura, Edna Teruko [UNIFESP] Nogueira, Celia Regina Mazeto, Glaucia M. F. S. Magalhaes, Patricia Kuenzle Ribeiro Nascimento, Marilza Leal Nesi-Franca, Suzana Vieira, Sandra Elisabete |
author_role |
author |
author2 |
Kimura, Edna Teruko [UNIFESP] Nogueira, Celia Regina Mazeto, Glaucia M. F. S. Magalhaes, Patricia Kuenzle Ribeiro Nascimento, Marilza Leal Nesi-Franca, Suzana Vieira, Sandra Elisabete |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de Santa Catarina (UFSC) Universidade Federal do Paraná (UFPR) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Maciel, Lea Maria Zanini Kimura, Edna Teruko [UNIFESP] Nogueira, Celia Regina Mazeto, Glaucia M. F. S. Magalhaes, Patricia Kuenzle Ribeiro Nascimento, Marilza Leal Nesi-Franca, Suzana Vieira, Sandra Elisabete |
dc.subject.por.fl_str_mv |
Congenital hypothyroidism neonatal screening |
topic |
Congenital hypothyroidism neonatal screening |
description |
Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it is a leading preventable mental retardation. Neonatal Screening Programs allow early identification of the disease and the adequate treatment of affected children can avoid the complications related to deprivation of the hormone. Most cases of primary congenital hypothyroidism (85%) are due to thyroid dysgenesis (ectopia, hypoplasia or agenesis) while the remaining result from defects in hormone synthesis. Affected children (> 95%) usually have no symptoms suggesting the disease at birth. The most frequent symptoms and signs are prolonged neonatal jaundice, hoarse cry, lethargy, slow movements, constipation, macroglossia, umbilical hernia, large fontanelle, hypotonia and dry skin. Around the world, various strategies are used for the screening of the CH. In Brazil, screening for CH is mandatory by law and usually done by serum TSH in dried blood collected from the heel. The recommended age for performing this test is after 48 hours of life until the 4th day. Diagnostic confirmation is required dosing TSH and free T-4 or total T-4 in serum. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 2018-06-15T14:00:11Z 2018-06-15T14:00:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-27302013000300004 Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013. 10.1590/S0004-27302013000300004 S0004-27302013000300004-en.pdf S0004-27302013000300004-pt.pdf 0004-2730 S0004-27302013000300004 http://repositorio.unifesp.br/handle/11600/42712 WOS:000319993400004 |
url |
http://dx.doi.org/10.1590/S0004-27302013000300004 http://repositorio.unifesp.br/handle/11600/42712 |
identifier_str_mv |
Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 3, p. 184-192, 2013. 10.1590/S0004-27302013000300004 S0004-27302013000300004-en.pdf S0004-27302013000300004-pt.pdf 0004-2730 S0004-27302013000300004 WOS:000319993400004 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros De Endocrinologia E Metabologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
184-192 |
dc.publisher.none.fl_str_mv |
Sbem-soc Brasil Endocrinologia & Metabologia |
publisher.none.fl_str_mv |
Sbem-soc Brasil Endocrinologia & Metabologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268348553232384 |