Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57565 http://dx.doi.org/10.1590/S1984-82502016000300005 |
Resumo: | The purpose of the work was to assess the incidence of potential drug interactions (pDDI), major pDDI, and the use of potentially inappropriate medication (PIM) at hospital admission, during hospitalization, and at discharge to evaluate whether hospital admission provides an opportunity for improving pharmacotherapy in elderly patients at a University hospital that has a clinical pharmacist. A prospective cohort study was carried out using data from the medical records of patients admitted to an internal medicine ward. All admissions and prescriptions were monitored between March and August 2006. Micromedex (R) DrugReax (R) and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs, respectively. A comparison of admission and discharge prescriptions showed the following: an increase in the proportion of patients using antithrombotic agents (76 versus 144; p< 0.001), lipid modifying agents (58 versus 81; p= 0.024), drugs for acid-related disorders (99 versus 152; p< 0.001), and particularly omeprazole (61 versus 87; p= 0.015); a decrease in the number of patients prescribed psycholeptics (73 versus 32; p< 0.001) and diazepam (54 versus 13; p< 0.001); and a decrease in the proportion of patients exposed to polypharmacy (16.1% versus 10.1%; p= 0.025), at least one pDDI (44.5% versus 32.8%; p= 0.002), major pDDI (19.9% versus 12.2%; p= 0.010) or PIM (85.8% versus 51.9%; p< 0.001). The conclusion is that admission to a hospital ward that has a clinical pharmacist was associated with a reduction in the number of patients exposed to polypharmacy, pDDI, major pDDI, and the use of PIMs among elderly inpatients. |
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de Melo, Daniela Oliveira [UNIFESP]Storpirtis, SilviaRibeiro, Eliane2020-08-14T13:44:16Z2020-08-14T13:44:16Z2016Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 52, n. 3, p. 391-401, 2016.1984-8250https://repositorio.unifesp.br/handle/11600/57565http://dx.doi.org/10.1590/S1984-82502016000300005WOS000390332400005.pdfS1984-8250201600030039110.1590/S1984-82502016000300005WOS:000390332400005The purpose of the work was to assess the incidence of potential drug interactions (pDDI), major pDDI, and the use of potentially inappropriate medication (PIM) at hospital admission, during hospitalization, and at discharge to evaluate whether hospital admission provides an opportunity for improving pharmacotherapy in elderly patients at a University hospital that has a clinical pharmacist. A prospective cohort study was carried out using data from the medical records of patients admitted to an internal medicine ward. All admissions and prescriptions were monitored between March and August 2006. Micromedex (R) DrugReax (R) and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs, respectively. A comparison of admission and discharge prescriptions showed the following: an increase in the proportion of patients using antithrombotic agents (76 versus 144; p< 0.001), lipid modifying agents (58 versus 81; p= 0.024), drugs for acid-related disorders (99 versus 152; p< 0.001), and particularly omeprazole (61 versus 87; p= 0.015); a decrease in the number of patients prescribed psycholeptics (73 versus 32; p< 0.001) and diazepam (54 versus 13; p< 0.001); and a decrease in the proportion of patients exposed to polypharmacy (16.1% versus 10.1%; p= 0.025), at least one pDDI (44.5% versus 32.8%; p= 0.002), major pDDI (19.9% versus 12.2%; p= 0.010) or PIM (85.8% versus 51.9%; p< 0.001). The conclusion is that admission to a hospital ward that has a clinical pharmacist was associated with a reduction in the number of patients exposed to polypharmacy, pDDI, major pDDI, and the use of PIMs among elderly inpatients.School of Pharmaceutical Sciences and the University Hospital of the University of Sao PauloCoordination for the Improvement of Higher Education Personnel (CAPES)Univ Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Sao Paulo, BrazilUniv Sao Paulo, Dept Pharm, Coll Pharmaceut Sci, Sao Paulo, BrazilUniv Sao Paulo, Univ Hosp, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Sao Paulo, BrazilCAPES: 140956/2006-9Web of Science391-401engUniv Sao Paulo, Conjunto QuimicasBrazilian Journal Of Pharmaceutical SciencesDoes hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo523info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000390332400005.pdfWOS000390332400005.pdfapplication/pdf374349${dspace.ui.url}/bitstream/11600/57565/1/WOS000390332400005.pdf36e5d0387c2429fb4cbffb41aee2c2f5MD51open accessTEXTWOS000390332400005.pdf.txtWOS000390332400005.pdf.txtExtracted texttext/plain42915${dspace.ui.url}/bitstream/11600/57565/8/WOS000390332400005.pdf.txt9c6b4e71dc40e0c0325e636ec30c133cMD58open accessTHUMBNAILWOS000390332400005.pdf.jpgWOS000390332400005.pdf.jpgIM Thumbnailimage/jpeg7980${dspace.ui.url}/bitstream/11600/57565/10/WOS000390332400005.pdf.jpg710da2806cd906e2ec3a18dac0475993MD510open access11600/575652023-06-05 19:23:50.47open accessoai:repositorio.unifesp.br:11600/57565Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:23:50Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
title |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
spellingShingle |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? de Melo, Daniela Oliveira [UNIFESP] |
title_short |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
title_full |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
title_fullStr |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
title_full_unstemmed |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
title_sort |
Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients? |
author |
de Melo, Daniela Oliveira [UNIFESP] |
author_facet |
de Melo, Daniela Oliveira [UNIFESP] Storpirtis, Silvia Ribeiro, Eliane |
author_role |
author |
author2 |
Storpirtis, Silvia Ribeiro, Eliane |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
de Melo, Daniela Oliveira [UNIFESP] Storpirtis, Silvia Ribeiro, Eliane |
description |
The purpose of the work was to assess the incidence of potential drug interactions (pDDI), major pDDI, and the use of potentially inappropriate medication (PIM) at hospital admission, during hospitalization, and at discharge to evaluate whether hospital admission provides an opportunity for improving pharmacotherapy in elderly patients at a University hospital that has a clinical pharmacist. A prospective cohort study was carried out using data from the medical records of patients admitted to an internal medicine ward. All admissions and prescriptions were monitored between March and August 2006. Micromedex (R) DrugReax (R) and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs, respectively. A comparison of admission and discharge prescriptions showed the following: an increase in the proportion of patients using antithrombotic agents (76 versus 144; p< 0.001), lipid modifying agents (58 versus 81; p= 0.024), drugs for acid-related disorders (99 versus 152; p< 0.001), and particularly omeprazole (61 versus 87; p= 0.015); a decrease in the number of patients prescribed psycholeptics (73 versus 32; p< 0.001) and diazepam (54 versus 13; p< 0.001); and a decrease in the proportion of patients exposed to polypharmacy (16.1% versus 10.1%; p= 0.025), at least one pDDI (44.5% versus 32.8%; p= 0.002), major pDDI (19.9% versus 12.2%; p= 0.010) or PIM (85.8% versus 51.9%; p< 0.001). The conclusion is that admission to a hospital ward that has a clinical pharmacist was associated with a reduction in the number of patients exposed to polypharmacy, pDDI, major pDDI, and the use of PIMs among elderly inpatients. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-08-14T13:44:16Z |
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2020-08-14T13:44:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 52, n. 3, p. 391-401, 2016. |
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https://repositorio.unifesp.br/handle/11600/57565 http://dx.doi.org/10.1590/S1984-82502016000300005 |
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1984-8250 |
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WOS000390332400005.pdf |
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S1984-82502016000300391 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1984-82502016000300005 |
dc.identifier.wos.none.fl_str_mv |
WOS:000390332400005 |
identifier_str_mv |
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 52, n. 3, p. 391-401, 2016. 1984-8250 WOS000390332400005.pdf S1984-82502016000300391 10.1590/S1984-82502016000300005 WOS:000390332400005 |
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https://repositorio.unifesp.br/handle/11600/57565 http://dx.doi.org/10.1590/S1984-82502016000300005 |
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Brazilian Journal Of Pharmaceutical Sciences |
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391-401 |
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Univ Sao Paulo, Conjunto Quimicas |
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Univ Sao Paulo, Conjunto Quimicas |
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