The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage

Detalhes bibliográficos
Autor(a) principal: Picão, Renata Cristina [UNIFESP]
Data de Publicação: 2013
Outros Autores: Cardoso, Juliana Pereira [UNIFESP], Campana, Eloiza Helena [UNIFESP], Nicoletti, Adriana Giannini [UNIFESP], Petrolini, Fernanda Villas Boas [UNIFESP], Assis, Diego Magno [UNIFESP], Juliano, Luiz [UNIFESP], Gales, Ana Cristina [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001
http://repositorio.unifesp.br/handle/11600/36224
Resumo: We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.
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spelling The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewageCarbapenemasesbla(KPC) disseminationWastewaterWe investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.Universidade Federal de São Paulo, Dept Med, Div Infectol, Lab ALERTA, São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilFundacao Parque Zool São Paulo, Lab Microbiol Aplicada, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Infectol, Lab ALERTA, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biofis, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sanofi-AventisThermo FisherbioMerieuxFAPESP: 2009/11051-0CNPq: 307816/2009-5CNPq: 302981/2011-0Elsevier B.V.Universidade Federal de São Paulo (UNIFESP)Universidade Federal do Rio de Janeiro (UFRJ)Fundacao Parque Zool São PauloPicão, Renata Cristina [UNIFESP]Cardoso, Juliana Pereira [UNIFESP]Campana, Eloiza Helena [UNIFESP]Nicoletti, Adriana Giannini [UNIFESP]Petrolini, Fernanda Villas Boas [UNIFESP]Assis, Diego Magno [UNIFESP]Juliano, Luiz [UNIFESP]Gales, Ana Cristina [UNIFESP]2016-01-24T14:31:36Z2016-01-24T14:31:36Z2013-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion80-85application/pdfhttp://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013.10.1016/j.diagmicrobio.2013.02.001WOS000318325900016.pdf0732-8893http://repositorio.unifesp.br/handle/11600/36224WOS:000318325900016engDiagnostic Microbiology and Infectious Diseaseinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T18:41:56Zoai:repositorio.unifesp.br/:11600/36224Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T18:41:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
title The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
spellingShingle The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
Picão, Renata Cristina [UNIFESP]
Carbapenemases
bla(KPC) dissemination
Wastewater
title_short The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
title_full The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
title_fullStr The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
title_full_unstemmed The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
title_sort The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
author Picão, Renata Cristina [UNIFESP]
author_facet Picão, Renata Cristina [UNIFESP]
Cardoso, Juliana Pereira [UNIFESP]
Campana, Eloiza Helena [UNIFESP]
Nicoletti, Adriana Giannini [UNIFESP]
Petrolini, Fernanda Villas Boas [UNIFESP]
Assis, Diego Magno [UNIFESP]
Juliano, Luiz [UNIFESP]
Gales, Ana Cristina [UNIFESP]
author_role author
author2 Cardoso, Juliana Pereira [UNIFESP]
Campana, Eloiza Helena [UNIFESP]
Nicoletti, Adriana Giannini [UNIFESP]
Petrolini, Fernanda Villas Boas [UNIFESP]
Assis, Diego Magno [UNIFESP]
Juliano, Luiz [UNIFESP]
Gales, Ana Cristina [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Fundacao Parque Zool São Paulo
dc.contributor.author.fl_str_mv Picão, Renata Cristina [UNIFESP]
Cardoso, Juliana Pereira [UNIFESP]
Campana, Eloiza Helena [UNIFESP]
Nicoletti, Adriana Giannini [UNIFESP]
Petrolini, Fernanda Villas Boas [UNIFESP]
Assis, Diego Magno [UNIFESP]
Juliano, Luiz [UNIFESP]
Gales, Ana Cristina [UNIFESP]
dc.subject.por.fl_str_mv Carbapenemases
bla(KPC) dissemination
Wastewater
topic Carbapenemases
bla(KPC) dissemination
Wastewater
description We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2-producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the bla(KPC-2) gene harbored on a transposon that was carried by conjugative plasmids. the presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. (C) 2013 Elsevier Inc. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-01
2016-01-24T14:31:36Z
2016-01-24T14:31:36Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001
Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013.
10.1016/j.diagmicrobio.2013.02.001
WOS000318325900016.pdf
0732-8893
http://repositorio.unifesp.br/handle/11600/36224
WOS:000318325900016
url http://dx.doi.org/10.1016/j.diagmicrobio.2013.02.001
http://repositorio.unifesp.br/handle/11600/36224
identifier_str_mv Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 76, n. 1, p. 80-85, 2013.
10.1016/j.diagmicrobio.2013.02.001
WOS000318325900016.pdf
0732-8893
WOS:000318325900016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diagnostic Microbiology and Infectious Disease
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 80-85
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268297767550976

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