Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0102-865020160120000002 https://repositorio.unifesp.br/handle/11600/56577 |
Resumo: | PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy's criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died) |
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Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamineLiver Failure, AcuteGalactosamineModels, AnimalRatsPURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy's criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died)group 2 (44 rats received a dose of 1.4 g/kg of d-galactosamine and blood and histological samples were collected for analysis at 12, 24, 48, 72 and 120 hours after the injection)and the control group as well (6 rats). RESULTS: Twelve hours after applying d-galactosamine, AST/ALT, bilirubin, factor V, PT and INR were already altered. The peak was reached at 48 hours. INR > 6.5 was found 12 hours after the injection and factor V < 30% after 24 hours. All the laboratory variables presented statistical differences, except urea (p = 0.758). There were statistical differences among all the histological variables analyzed. CONCLUSION: King's College and Clichy's criteria were fulfilled 12 hours after the d-galactosamine injection and this time may represent the best time to intervene in this acute liver failure animal model.Univ Fed Sao Paulo UNIFESP, Postgrad Program Interdisciplinary Surg Sci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Sch Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Surg, Lab Surg Tech & Expt Surg, Sao Paulo, BrazilPostgraduate Program in Interdisciplinary Surgical Science, Universidade Federal de São Paulo (UNIFESP), BrazilDepartment of Surgery, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, BrazilPediatric Department, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, BrazilDepartment of Pathology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, BrazilSchool of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, BrazilWeb of ScienceActa Cirurgica Brasileira2020-07-31T12:47:05Z2020-07-31T12:47:05Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion783-792application/pdfhttp://dx.doi.org/10.1590/S0102-865020160120000002Acta Cirurgica Brasileira. Sao Paulo, v. 31, n. 12, p. 783-792, 2016.10.1590/S0102-865020160120000002S0102-86502016001200783.pdf0102-8650S0102-86502016001200783https://repositorio.unifesp.br/handle/11600/56577WOS:000393790500002engActa Cirurgica BrasileiraSao Pauloinfo:eu-repo/semantics/openAccessEboli, Ligia Patricia de Carvalho Batista [UNIFESP]Salzedas-Netto, Alcides Augusto [UNIFESP]Azevedo, Ramiro Antero de [UNIFESP]Lanzoni, Valeria Pereira [UNIFESP]Paula, Tatiana Sugayama de [UNIFESP]Goldenberg, Alberto [UNIFESP]Gonzalez, Adriano Miziara [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T10:25:46Zoai:repositorio.unifesp.br/:11600/56577Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T10:25:46Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| title |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| spellingShingle |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine Eboli, Ligia Patricia de Carvalho Batista [UNIFESP] Liver Failure, Acute Galactosamine Models, Animal Rats |
| title_short |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| title_full |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| title_fullStr |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| title_full_unstemmed |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| title_sort |
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine |
| author |
Eboli, Ligia Patricia de Carvalho Batista [UNIFESP] |
| author_facet |
Eboli, Ligia Patricia de Carvalho Batista [UNIFESP] Salzedas-Netto, Alcides Augusto [UNIFESP] Azevedo, Ramiro Antero de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Paula, Tatiana Sugayama de [UNIFESP] Goldenberg, Alberto [UNIFESP] Gonzalez, Adriano Miziara [UNIFESP] |
| author_role |
author |
| author2 |
Salzedas-Netto, Alcides Augusto [UNIFESP] Azevedo, Ramiro Antero de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Paula, Tatiana Sugayama de [UNIFESP] Goldenberg, Alberto [UNIFESP] Gonzalez, Adriano Miziara [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Eboli, Ligia Patricia de Carvalho Batista [UNIFESP] Salzedas-Netto, Alcides Augusto [UNIFESP] Azevedo, Ramiro Antero de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Paula, Tatiana Sugayama de [UNIFESP] Goldenberg, Alberto [UNIFESP] Gonzalez, Adriano Miziara [UNIFESP] |
| dc.subject.por.fl_str_mv |
Liver Failure, Acute Galactosamine Models, Animal Rats |
| topic |
Liver Failure, Acute Galactosamine Models, Animal Rats |
| description |
PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy's criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three groups: group 1 (11 rats received 1.4 g/kg of d-galactosamine intraperitoneally and were observed until they died) |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:05Z 2020-07-31T12:47:05Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-865020160120000002 Acta Cirurgica Brasileira. Sao Paulo, v. 31, n. 12, p. 783-792, 2016. 10.1590/S0102-865020160120000002 S0102-86502016001200783.pdf 0102-8650 S0102-86502016001200783 https://repositorio.unifesp.br/handle/11600/56577 WOS:000393790500002 |
| url |
http://dx.doi.org/10.1590/S0102-865020160120000002 https://repositorio.unifesp.br/handle/11600/56577 |
| identifier_str_mv |
Acta Cirurgica Brasileira. Sao Paulo, v. 31, n. 12, p. 783-792, 2016. 10.1590/S0102-865020160120000002 S0102-86502016001200783.pdf 0102-8650 S0102-86502016001200783 WOS:000393790500002 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
783-792 application/pdf |
| dc.coverage.none.fl_str_mv |
Sao Paulo |
| dc.publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
| publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1814268340236976128 |