A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fertnstert.2009.11.037 http://repositorio.unifesp.br/handle/11600/32545 |
Resumo: | Objective: To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis.Design: Pharmacologic interventions in an experimental model of peritoneal endometriosis.Setting: Research laboratory in the Federal University of Rio de Janeiro.Animal(s): Twenty female Sprague-Dawley rats with experimentally induced endometriosis.Intervention(s): After implantation and establishment of autologous endometrium onto the peritoneum abdominal wall, rats were randomized into groups and treated with parecoxib or the vehicle by IM injection for 30 days.Main Outcome Measure(s): Vascular density, the expression of vascular endothelial growth factor (VEGF) and its receptor Flk-1, the distribution of activated macrophages, the expression of COX-2, and the prostaglandin concentration in the endometriotic lesions treated with parecoxib were analyzed.Result(s): the treatment significantly decreased the implant size, and histologic examination indicated mostly atrophy and regression. A reduction in microvessel density and in the number of macrophages, associated with decreased expression of VEGF and Flk-1, also were observed. the treatment group showed a low concentration of prostaglandin E(2).Conclusion(s): These results suggest that the use of COX-2 selective inhibitors could be effective to suppress the establishment and growth of endometriosis, partially through their antiangiogenic activity. (Fertil Steril (R) 2010; 93: 2674-9. (C) 2010 by American Society for Reproductive Medicine.) |
id |
UFSP_51e5def3149dde911541a1cfe98221c1 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/32545 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat modelAngiogenesisCOX-2 inhibitorendometriosisPGE(2)vascularizationVEGFObjective: To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis.Design: Pharmacologic interventions in an experimental model of peritoneal endometriosis.Setting: Research laboratory in the Federal University of Rio de Janeiro.Animal(s): Twenty female Sprague-Dawley rats with experimentally induced endometriosis.Intervention(s): After implantation and establishment of autologous endometrium onto the peritoneum abdominal wall, rats were randomized into groups and treated with parecoxib or the vehicle by IM injection for 30 days.Main Outcome Measure(s): Vascular density, the expression of vascular endothelial growth factor (VEGF) and its receptor Flk-1, the distribution of activated macrophages, the expression of COX-2, and the prostaglandin concentration in the endometriotic lesions treated with parecoxib were analyzed.Result(s): the treatment significantly decreased the implant size, and histologic examination indicated mostly atrophy and regression. A reduction in microvessel density and in the number of macrophages, associated with decreased expression of VEGF and Flk-1, also were observed. the treatment group showed a low concentration of prostaglandin E(2).Conclusion(s): These results suggest that the use of COX-2 selective inhibitors could be effective to suppress the establishment and growth of endometriosis, partially through their antiangiogenic activity. (Fertil Steril (R) 2010; 93: 2674-9. (C) 2010 by American Society for Reproductive Medicine.)Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Ilha Fundao, Programa Pesquisa Biol Celular & Desenvolvimento, BR-21941590 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Ciencias Biomed, Programa Pesquisa Desenvolvimento Farmacos, BR-21941590 Rio de Janeiro, BrazilUniv São Paulo, Fac Med, Dept Obstet & Ginecol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Elsevier B.V.Universidade Federal do Rio de Janeiro (UFRJ)Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Machado, Daniel EscorsimBerardo, Plinio TostesLandgraf, Richardt Gama [UNIFESP]Fernandes, Patricia DiasPalmero, CeliaAlves, Leandro MirandaAbrao, Mauricio SimoesNasciutti, Luiz Eurico2016-01-24T13:59:41Z2016-01-24T13:59:41Z2010-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2674-2679http://dx.doi.org/10.1016/j.fertnstert.2009.11.037Fertility and Sterility. New York: Elsevier B.V., v. 93, n. 8, p. 2674-2679, 2010.10.1016/j.fertnstert.2009.11.0370015-0282http://repositorio.unifesp.br/handle/11600/32545WOS:000277608700030engFertility and Sterilityinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T11:59:41Zoai:repositorio.unifesp.br/:11600/32545Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T11:59:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
title |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
spellingShingle |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model Machado, Daniel Escorsim Angiogenesis COX-2 inhibitor endometriosis PGE(2) vascularization VEGF |
title_short |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
title_full |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
title_fullStr |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
title_full_unstemmed |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
title_sort |
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model |
author |
Machado, Daniel Escorsim |
author_facet |
Machado, Daniel Escorsim Berardo, Plinio Tostes Landgraf, Richardt Gama [UNIFESP] Fernandes, Patricia Dias Palmero, Celia Alves, Leandro Miranda Abrao, Mauricio Simoes Nasciutti, Luiz Eurico |
author_role |
author |
author2 |
Berardo, Plinio Tostes Landgraf, Richardt Gama [UNIFESP] Fernandes, Patricia Dias Palmero, Celia Alves, Leandro Miranda Abrao, Mauricio Simoes Nasciutti, Luiz Eurico |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio de Janeiro (UFRJ) Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Machado, Daniel Escorsim Berardo, Plinio Tostes Landgraf, Richardt Gama [UNIFESP] Fernandes, Patricia Dias Palmero, Celia Alves, Leandro Miranda Abrao, Mauricio Simoes Nasciutti, Luiz Eurico |
dc.subject.por.fl_str_mv |
Angiogenesis COX-2 inhibitor endometriosis PGE(2) vascularization VEGF |
topic |
Angiogenesis COX-2 inhibitor endometriosis PGE(2) vascularization VEGF |
description |
Objective: To analyze the antiangiogenic effects of the selective cyclooxygenase-2 (COX-2) inhibitor parecoxib on the growth of endometrial implants in a rat model of peritoneal endometriosis.Design: Pharmacologic interventions in an experimental model of peritoneal endometriosis.Setting: Research laboratory in the Federal University of Rio de Janeiro.Animal(s): Twenty female Sprague-Dawley rats with experimentally induced endometriosis.Intervention(s): After implantation and establishment of autologous endometrium onto the peritoneum abdominal wall, rats were randomized into groups and treated with parecoxib or the vehicle by IM injection for 30 days.Main Outcome Measure(s): Vascular density, the expression of vascular endothelial growth factor (VEGF) and its receptor Flk-1, the distribution of activated macrophages, the expression of COX-2, and the prostaglandin concentration in the endometriotic lesions treated with parecoxib were analyzed.Result(s): the treatment significantly decreased the implant size, and histologic examination indicated mostly atrophy and regression. A reduction in microvessel density and in the number of macrophages, associated with decreased expression of VEGF and Flk-1, also were observed. the treatment group showed a low concentration of prostaglandin E(2).Conclusion(s): These results suggest that the use of COX-2 selective inhibitors could be effective to suppress the establishment and growth of endometriosis, partially through their antiangiogenic activity. (Fertil Steril (R) 2010; 93: 2674-9. (C) 2010 by American Society for Reproductive Medicine.) |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05-15 2016-01-24T13:59:41Z 2016-01-24T13:59:41Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fertnstert.2009.11.037 Fertility and Sterility. New York: Elsevier B.V., v. 93, n. 8, p. 2674-2679, 2010. 10.1016/j.fertnstert.2009.11.037 0015-0282 http://repositorio.unifesp.br/handle/11600/32545 WOS:000277608700030 |
url |
http://dx.doi.org/10.1016/j.fertnstert.2009.11.037 http://repositorio.unifesp.br/handle/11600/32545 |
identifier_str_mv |
Fertility and Sterility. New York: Elsevier B.V., v. 93, n. 8, p. 2674-2679, 2010. 10.1016/j.fertnstert.2009.11.037 0015-0282 WOS:000277608700030 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fertility and Sterility |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
dc.format.none.fl_str_mv |
2674-2679 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268413606887424 |