Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1111/jgs.12416 http://repositorio.unifesp.br/handle/11600/36676 |
Resumo: | ObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk. |
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Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Studycognitive impairmentpulse pressureambulatory blood pressureblood pressurehypertensionObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.Kings Coll London, Inst Psychiat, London, EnglandUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, EnglandUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilMed Res Council Study Hlth & Dev, London, EnglandUniv Cent Lancashire, Sch Hlth, Preston PR1 2HE, Lancs, EnglandUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilWeb of ScienceWellcome TrustBritish Heart FoundationUK Medical Research CouncilDiabetes UKNational Institute for Health Research (NIHR) Biomedical Research CentreDementia Biomedical Research Unit at South LondonMaudsley NHS Foundation TrustKing's College LondonWiley-BlackwellKings Coll LondonUniv London Imperial Coll Sci Technol & MedUniversidade Federal de São Paulo (UNIFESP)Med Res Council Study Hlth & DevUniv Cent LancashireTaylor, ClareTillin, ThereseChaturvedi, NishDewey, MichaelFerri, Cleusa Pinheiro [UNIFESP]Hughes, AlunPrince, MartinRichards, MarcusShah, AjitStewart, Robert2016-01-24T14:34:19Z2016-01-24T14:34:19Z2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1489-1498application/pdfhttp://dx.doi.org/10.1111/jgs.12416Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013.10.1111/jgs.12416WOS000324307200007.pdf0002-8614http://repositorio.unifesp.br/handle/11600/36676WOS:000324307200007engJournal of the American Geriatrics Societyinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T15:27:05Zoai:repositorio.unifesp.br/:11600/36676Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T15:27:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
title |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
spellingShingle |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study Taylor, Clare cognitive impairment pulse pressure ambulatory blood pressure blood pressure hypertension |
title_short |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
title_full |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
title_fullStr |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
title_full_unstemmed |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
title_sort |
Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study |
author |
Taylor, Clare |
author_facet |
Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa Pinheiro [UNIFESP] Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert |
author_role |
author |
author2 |
Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa Pinheiro [UNIFESP] Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Kings Coll London Univ London Imperial Coll Sci Technol & Med Universidade Federal de São Paulo (UNIFESP) Med Res Council Study Hlth & Dev Univ Cent Lancashire |
dc.contributor.author.fl_str_mv |
Taylor, Clare Tillin, Therese Chaturvedi, Nish Dewey, Michael Ferri, Cleusa Pinheiro [UNIFESP] Hughes, Alun Prince, Martin Richards, Marcus Shah, Ajit Stewart, Robert |
dc.subject.por.fl_str_mv |
cognitive impairment pulse pressure ambulatory blood pressure blood pressure hypertension |
topic |
cognitive impairment pulse pressure ambulatory blood pressure blood pressure hypertension |
description |
ObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 2016-01-24T14:34:19Z 2016-01-24T14:34:19Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jgs.12416 Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013. 10.1111/jgs.12416 WOS000324307200007.pdf 0002-8614 http://repositorio.unifesp.br/handle/11600/36676 WOS:000324307200007 |
url |
http://dx.doi.org/10.1111/jgs.12416 http://repositorio.unifesp.br/handle/11600/36676 |
identifier_str_mv |
Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013. 10.1111/jgs.12416 WOS000324307200007.pdf 0002-8614 WOS:000324307200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the American Geriatrics Society |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
dc.format.none.fl_str_mv |
1489-1498 application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268444875423744 |