Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study

Detalhes bibliográficos
Autor(a) principal: Taylor, Clare
Data de Publicação: 2013
Outros Autores: Tillin, Therese, Chaturvedi, Nish, Dewey, Michael, Ferri, Cleusa Pinheiro [UNIFESP], Hughes, Alun, Prince, Martin, Richards, Marcus, Shah, Ajit, Stewart, Robert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/jgs.12416
http://repositorio.unifesp.br/handle/11600/36676
Resumo: ObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.
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spelling Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Studycognitive impairmentpulse pressureambulatory blood pressureblood pressurehypertensionObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.Kings Coll London, Inst Psychiat, London, EnglandUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, EnglandUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilMed Res Council Study Hlth & Dev, London, EnglandUniv Cent Lancashire, Sch Hlth, Preston PR1 2HE, Lancs, EnglandUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilWeb of ScienceWellcome TrustBritish Heart FoundationUK Medical Research CouncilDiabetes UKNational Institute for Health Research (NIHR) Biomedical Research CentreDementia Biomedical Research Unit at South LondonMaudsley NHS Foundation TrustKing's College LondonWiley-BlackwellKings Coll LondonUniv London Imperial Coll Sci Technol & MedUniversidade Federal de São Paulo (UNIFESP)Med Res Council Study Hlth & DevUniv Cent LancashireTaylor, ClareTillin, ThereseChaturvedi, NishDewey, MichaelFerri, Cleusa Pinheiro [UNIFESP]Hughes, AlunPrince, MartinRichards, MarcusShah, AjitStewart, Robert2016-01-24T14:34:19Z2016-01-24T14:34:19Z2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1489-1498application/pdfhttp://dx.doi.org/10.1111/jgs.12416Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013.10.1111/jgs.12416WOS000324307200007.pdf0002-8614http://repositorio.unifesp.br/handle/11600/36676WOS:000324307200007engJournal of the American Geriatrics Societyinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T15:27:05Zoai:repositorio.unifesp.br/:11600/36676Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T15:27:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
title Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
spellingShingle Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
Taylor, Clare
cognitive impairment
pulse pressure
ambulatory blood pressure
blood pressure
hypertension
title_short Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
title_full Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
title_fullStr Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
title_full_unstemmed Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
title_sort Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study
author Taylor, Clare
author_facet Taylor, Clare
Tillin, Therese
Chaturvedi, Nish
Dewey, Michael
Ferri, Cleusa Pinheiro [UNIFESP]
Hughes, Alun
Prince, Martin
Richards, Marcus
Shah, Ajit
Stewart, Robert
author_role author
author2 Tillin, Therese
Chaturvedi, Nish
Dewey, Michael
Ferri, Cleusa Pinheiro [UNIFESP]
Hughes, Alun
Prince, Martin
Richards, Marcus
Shah, Ajit
Stewart, Robert
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Kings Coll London
Univ London Imperial Coll Sci Technol & Med
Universidade Federal de São Paulo (UNIFESP)
Med Res Council Study Hlth & Dev
Univ Cent Lancashire
dc.contributor.author.fl_str_mv Taylor, Clare
Tillin, Therese
Chaturvedi, Nish
Dewey, Michael
Ferri, Cleusa Pinheiro [UNIFESP]
Hughes, Alun
Prince, Martin
Richards, Marcus
Shah, Ajit
Stewart, Robert
dc.subject.por.fl_str_mv cognitive impairment
pulse pressure
ambulatory blood pressure
blood pressure
hypertension
topic cognitive impairment
pulse pressure
ambulatory blood pressure
blood pressure
hypertension
description ObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.
publishDate 2013
dc.date.none.fl_str_mv 2013-09-01
2016-01-24T14:34:19Z
2016-01-24T14:34:19Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/jgs.12416
Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013.
10.1111/jgs.12416
WOS000324307200007.pdf
0002-8614
http://repositorio.unifesp.br/handle/11600/36676
WOS:000324307200007
url http://dx.doi.org/10.1111/jgs.12416
http://repositorio.unifesp.br/handle/11600/36676
identifier_str_mv Journal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013.
10.1111/jgs.12416
WOS000324307200007.pdf
0002-8614
WOS:000324307200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the American Geriatrics Society
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 1489-1498
application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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