Epidemiological assessment and therapeutic response in hypopharyngeal cancer

• Autor(a) principal: Amar, Ali [UNIFESP]
• Data de Publicação: 2013
• Outros Autores: Curioni, Otavio Alberto, Paiva, Diogenes Lopes de, Rapoport, Abrao, Dedivitis, Rogerio Aparecido, Cernea, Claudio Roberto, Brandao, Lenine Garcia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.5935/1808-8694.20130089; http://repositorio.unifesp.br/handle/11600/36467
• topic: epidemiology; hypopharyngeal neoplasms; neoplasm staging; squamous cell carcinoma; survival analysis

Despite the low incidence, diagnostic and therapeutic advances, hypopharyngeal cancer still has high mortality.Objective: To evaluate retrospectively the epidemiological profile and response to surgery and radiation/chemotherapy of patients with hypopharyngeal cancer.Method: We reviewed the medical records of 114 patients treated between 2002 and 2009 in a tertiary hospital with histopathological diagnosis of squamous cell carcinoma.Results: the mean age of the patients was 57 years, 94.7% were males and 5.3% females, 98.2% were smokers and 92% consumed alcohol; 72% are illiterate or did not complete first grade schooling. the main complaints were: neck node (28%), pain and dysphagia (22%), odynophagia (12.2%), dysphonia (7.8%). the clinical staging was: I (1.7%), II (3.5%), III (18.4%), IV (76.3%). the treatment was carried out with radiotherapy and chemotherapy alone in 35%, with mean 2-year survival of 20% and 5-year survival of 18%; surgery followed by radiotherapy and chemotherapy in 22.8% with 2-year survival of 60.0% and 5 years of 55.0%; chemotherapy alone in 2.6%, and 39.4% without treatment.Conclusion: Most patients already had advanced clinical stages and independent of the treatment option, had a low survival rate, confirming the poor prognosis of this neoplasm.