Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0066-782X2010005000024 http://repositorio.unifesp.br/handle/11600/5715 |
Resumo: | BACKGROUND: Cardiac involvement is known to occur in patients with Duchenne muscular dystrophy (DMD). The electrocardiogram (ECG) shows some typical changes in DMD, which makes it a useful test for the diagnosis of cardiac lesion in this disease. OBJECTIVE: To evaluate the electrocardiographic changes in patients with DMD and to correlate these changes with the age of the population studied. METHODS: ECG of 131 patients diagnosed with DMD were examined. Several electrocardiographic variables were analyzed, and the patients were divided into two groups - one with and one without changes, for each variable studied. The correlation between the two groups and the age of the patients was analyzed. Garson's criteria were used to establish the electrocardiographic parameters of normality. RESULTS: ECG was abnormal in 78.6% of the patients. All showed normal sinus rhythm. The following percentages were found for the main variables studied: short PR interval = 18.3%; abnormal R waves in V1 = 29.7%; abnormal Q waves in V6 = 21.3%; abnormal ventricular repolarization = 54.9%; abnormal QS waves in inferior and/or upper lateral wall = 37.4%; conduction disturbances in right bundle branch = 55.7%; prolonged QT C interval = 35.8%, and wide QRS = 23.6%. Unpaired t test was used to establish the correlation between age and the electrocardiographic variables studied in the two groups. Statistically significant differences were found only for the abnormal repolarization variable. CONCLUSION: Electrocardiographic abnormalities are common in DMD, revealing early cardiac involvement. Only the abnormal ventricular repolarization variable was more frequent, however at a lower age range (p < 0.05). |
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Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientesDuchenne muscular dystrophy: electrocardiographic analysis of 131 patientsDistrofia muscular de duchenne: análisis electrocardiográfica de 131 pacientesMuscular dystrophy, Duchenneelectrocardiographyheart blockDistrofia muscular de Duchenneeletrocardiografiabloqueio cardíacoBACKGROUND: Cardiac involvement is known to occur in patients with Duchenne muscular dystrophy (DMD). The electrocardiogram (ECG) shows some typical changes in DMD, which makes it a useful test for the diagnosis of cardiac lesion in this disease. OBJECTIVE: To evaluate the electrocardiographic changes in patients with DMD and to correlate these changes with the age of the population studied. METHODS: ECG of 131 patients diagnosed with DMD were examined. Several electrocardiographic variables were analyzed, and the patients were divided into two groups - one with and one without changes, for each variable studied. The correlation between the two groups and the age of the patients was analyzed. Garson's criteria were used to establish the electrocardiographic parameters of normality. RESULTS: ECG was abnormal in 78.6% of the patients. All showed normal sinus rhythm. The following percentages were found for the main variables studied: short PR interval = 18.3%; abnormal R waves in V1 = 29.7%; abnormal Q waves in V6 = 21.3%; abnormal ventricular repolarization = 54.9%; abnormal QS waves in inferior and/or upper lateral wall = 37.4%; conduction disturbances in right bundle branch = 55.7%; prolonged QT C interval = 35.8%, and wide QRS = 23.6%. Unpaired t test was used to establish the correlation between age and the electrocardiographic variables studied in the two groups. Statistically significant differences were found only for the abnormal repolarization variable. CONCLUSION: Electrocardiographic abnormalities are common in DMD, revealing early cardiac involvement. Only the abnormal ventricular repolarization variable was more frequent, however at a lower age range (p < 0.05).FUNDAMENTO: Se sabe de la afectación cardíaca en pacientes con distrofia muscular de Duchenne (DMD). El electrocardiograma (ECG) presenta algunas alteraciones típicas en la DMD, hecho que lo convierte en un examen útil en el diagnóstico de la lesión cardíaca en esta patología. OBJETIVO: Evaluar las alteraciones electrocardiográficas en pacientes portadores de DMD, correlacionándolas con la edad de la población estudiada. MÉTODOS: Se analizaron los ECG de 131 pacientes con diagnóstico de DMD. Se evaluaron diversas variables electrocardiográficas, y los pacientes fueron separados en dos grupos: aquellos con y sin alteraciones, por variable estudiada. Se hizo la correlación de estos dos grupos con la edad de los pacientes. Se utilizaron los criterios de Garson para establecer los parámetros electrocardiográficos de normalidad. RESULTADOS: El ECG estaba anormal en un 78,6% de los pacientes. Todos presentaban ritmo sinusal. Fueron los que siguen a continuación los porcentuales encontrados para las principales variables estudiadas: PR corto = 18,3%, ondas R anormales en V1 = 29,7%, ondas Q anormales en V6 = 21,3%, alteraciones de la repolarización ventricular = 54,9%, ondas QS anormales en paredes inferior y/o lateral alta = 37,4%, disturbios de conducción por la rama derecha = 55,7%, intervalo QTc prolongado = 35,8% y ensanchamiento del QRS = 23,6%. La prueba t no pareado se utilizó para establecerse la correlación de la edad con las variables electrocardiográficas estudiadas en los dos grupos, y solamente la variable alteración de la repolarización mostró diferencia estadísticamente significativa. CONCLUSIÓN: Las alteraciones electrocardiográficas en la DMD son frecuentes, revelando compromiso cardiaco precoz. Solamente la variable alteración de la repolarización ventricular fue más frecuente, sin embargo en grupo de edad menor (p < 0,05).FUNDAMENTO: É conhecido o envolvimento cardíaco em pacientes com distrofia muscular de Duchenne (DMD). O eletrocardiograma (ECG) apresenta algumas alterações típicas na DMD, fato que o torna um exame útil no diagnóstico da lesão cardíaca nessa patologia. OBJETIVO: Avaliar as alterações eletrocardiográficas em pacientes portadores de DMD, correlacionando-as com a idade da população estudada. MÉTODOS: Foram analisados os ECG de 131 pacientes com diagnóstico de DMD. Avaliaram-se diversas variáveis eletrocardiográficas, sendo os pacientes separados em dois grupos: aqueles com e sem alterações, por variável estudada. Fez-se a correlação desses dois grupos com a idade dos pacientes. Foram utilizados os critérios de Garson para estabelecer os parâmetros eletrocardiográficos de normalidade. RESULTADOS: O ECG estava anormal em 78,6% dos pacientes. Todos apresentavam ritmo sinusal. Foram os seguintes os percentuais encontrados para as principais variáveis estudadas: PR curto = 18,3%, ondas R anormais em V1 = 29,7%, ondas Q anormais em V6 = 21,3%, alterações da repolarização ventricular = 54,9%, ondas QS anormais em paredes inferior e/ou lateral alta = 37,4%, distúrbios de condução pelo ramo direito = 55,7%, intervalo QT C prolongado = 35,8% e alargamento do QRS = 23,6%. O teste t não pareado foi utilizado para se estabelecer a correlação da idade com as variáveis eletrocardiográficas estudadas nos dois grupos e, apenas a variável alteração da repolarização mostrou diferença estatisticamente significante. CONCLUSÃO: As alterações eletrocardiográficas na DMD são frequentes, revelando comprometimento cardíaco precoce. Apenas a variável alteração da repolarização ventricular foi mais frequente, porém em faixa etária menor (p < 0,05).Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOSociedade Brasileira de Cardiologia - SBCUniversidade Federal de São Paulo (UNIFESP)Santos, Maria Auxiliadora Bonfim [UNIFESP]Costa, Francisco de Assis [UNIFESP]Travessa, Aline Ferreira [UNIFESP]Bombig, Maria Teresa Nogueira [UNIFESP]Fonseca, Francisco Antonio Helfenstein [UNIFESP]Luna Filho, Bráulio [UNIFESP]Mussi, Aurélia [UNIFESP]Souza, Dilma de [UNIFESP]Oliveira, Acary Souza Bulle [UNIFESP]Póvoa, Rui Manuel dos Santos [UNIFESP]2015-06-14T13:41:39Z2015-06-14T13:41:39Z2010-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion620-624application/pdfhttp://dx.doi.org/10.1590/S0066-782X2010005000024Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 94, n. 5, p. 620-624, 2010.10.1590/S0066-782X2010005000024S0066-782X2010000500008.pdf0066-782XS0066-782X2010000500008http://repositorio.unifesp.br/handle/11600/5715porArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-14T13:57:36Zoai:repositorio.unifesp.br/:11600/5715Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-10-14T13:57:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes Duchenne muscular dystrophy: electrocardiographic analysis of 131 patients Distrofia muscular de duchenne: análisis electrocardiográfica de 131 pacientes |
title |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
spellingShingle |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes Santos, Maria Auxiliadora Bonfim [UNIFESP] Muscular dystrophy, Duchenne electrocardiography heart block Distrofia muscular de Duchenne eletrocardiografia bloqueio cardíaco |
title_short |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
title_full |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
title_fullStr |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
title_full_unstemmed |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
title_sort |
Distrofia muscular de Duchenne: análise eletrocardiográfica de 131 pacientes |
author |
Santos, Maria Auxiliadora Bonfim [UNIFESP] |
author_facet |
Santos, Maria Auxiliadora Bonfim [UNIFESP] Costa, Francisco de Assis [UNIFESP] Travessa, Aline Ferreira [UNIFESP] Bombig, Maria Teresa Nogueira [UNIFESP] Fonseca, Francisco Antonio Helfenstein [UNIFESP] Luna Filho, Bráulio [UNIFESP] Mussi, Aurélia [UNIFESP] Souza, Dilma de [UNIFESP] Oliveira, Acary Souza Bulle [UNIFESP] Póvoa, Rui Manuel dos Santos [UNIFESP] |
author_role |
author |
author2 |
Costa, Francisco de Assis [UNIFESP] Travessa, Aline Ferreira [UNIFESP] Bombig, Maria Teresa Nogueira [UNIFESP] Fonseca, Francisco Antonio Helfenstein [UNIFESP] Luna Filho, Bráulio [UNIFESP] Mussi, Aurélia [UNIFESP] Souza, Dilma de [UNIFESP] Oliveira, Acary Souza Bulle [UNIFESP] Póvoa, Rui Manuel dos Santos [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Santos, Maria Auxiliadora Bonfim [UNIFESP] Costa, Francisco de Assis [UNIFESP] Travessa, Aline Ferreira [UNIFESP] Bombig, Maria Teresa Nogueira [UNIFESP] Fonseca, Francisco Antonio Helfenstein [UNIFESP] Luna Filho, Bráulio [UNIFESP] Mussi, Aurélia [UNIFESP] Souza, Dilma de [UNIFESP] Oliveira, Acary Souza Bulle [UNIFESP] Póvoa, Rui Manuel dos Santos [UNIFESP] |
dc.subject.por.fl_str_mv |
Muscular dystrophy, Duchenne electrocardiography heart block Distrofia muscular de Duchenne eletrocardiografia bloqueio cardíaco |
topic |
Muscular dystrophy, Duchenne electrocardiography heart block Distrofia muscular de Duchenne eletrocardiografia bloqueio cardíaco |
description |
BACKGROUND: Cardiac involvement is known to occur in patients with Duchenne muscular dystrophy (DMD). The electrocardiogram (ECG) shows some typical changes in DMD, which makes it a useful test for the diagnosis of cardiac lesion in this disease. OBJECTIVE: To evaluate the electrocardiographic changes in patients with DMD and to correlate these changes with the age of the population studied. METHODS: ECG of 131 patients diagnosed with DMD were examined. Several electrocardiographic variables were analyzed, and the patients were divided into two groups - one with and one without changes, for each variable studied. The correlation between the two groups and the age of the patients was analyzed. Garson's criteria were used to establish the electrocardiographic parameters of normality. RESULTS: ECG was abnormal in 78.6% of the patients. All showed normal sinus rhythm. The following percentages were found for the main variables studied: short PR interval = 18.3%; abnormal R waves in V1 = 29.7%; abnormal Q waves in V6 = 21.3%; abnormal ventricular repolarization = 54.9%; abnormal QS waves in inferior and/or upper lateral wall = 37.4%; conduction disturbances in right bundle branch = 55.7%; prolonged QT C interval = 35.8%, and wide QRS = 23.6%. Unpaired t test was used to establish the correlation between age and the electrocardiographic variables studied in the two groups. Statistically significant differences were found only for the abnormal repolarization variable. CONCLUSION: Electrocardiographic abnormalities are common in DMD, revealing early cardiac involvement. Only the abnormal ventricular repolarization variable was more frequent, however at a lower age range (p < 0.05). |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05-01 2015-06-14T13:41:39Z 2015-06-14T13:41:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0066-782X2010005000024 Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 94, n. 5, p. 620-624, 2010. 10.1590/S0066-782X2010005000024 S0066-782X2010000500008.pdf 0066-782X S0066-782X2010000500008 http://repositorio.unifesp.br/handle/11600/5715 |
url |
http://dx.doi.org/10.1590/S0066-782X2010005000024 http://repositorio.unifesp.br/handle/11600/5715 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 94, n. 5, p. 620-624, 2010. 10.1590/S0066-782X2010005000024 S0066-782X2010000500008.pdf 0066-782X S0066-782X2010000500008 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
620-624 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268456861696000 |