Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?

Detalhes bibliográficos
Autor(a) principal: Camargo, Luis Fernando Aranha [UNIFESP]
Data de Publicação: 2008
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1097/SHK.0b013e318181a6e4
http://repositorio.unifesp.br/handle/11600/30231
Resumo: Staphylococcus aureus is a frequent agent of serious intensive care unit infections with high associated mortality rates. Resistance to methicillin is frequent, exceeding 50% in many countries, and for these strains, vancomycin is the agent of choice. Resistance to this drug is now frequent for Enterococcus, but low rates are reported for S. aureus. Nonetheless, treatment failures with vancomycin for infections caused by strains considered susceptible have been reported during recent years. This article aims to review the possible explanations for this phenomenon, which is challenging the old paradigm of S. aureus infections and vancomycin use.
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spelling Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?Staphylococcus aureusvancomycinfailureresistanceStaphylococcus aureus is a frequent agent of serious intensive care unit infections with high associated mortality rates. Resistance to methicillin is frequent, exceeding 50% in many countries, and for these strains, vancomycin is the agent of choice. Resistance to this drug is now frequent for Enterococcus, but low rates are reported for S. aureus. Nonetheless, treatment failures with vancomycin for infections caused by strains considered susceptible have been reported during recent years. This article aims to review the possible explanations for this phenomenon, which is challenging the old paradigm of S. aureus infections and vancomycin use.Universidade Federal de São Paulo, Dept Infect Dis, BR-05685090 São Paulo, BrazilHosp Israelita Albert Einstein, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Infect Dis, BR-05685090 São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Hosp Israelita Albert EinsteinCamargo, Luis Fernando Aranha [UNIFESP]2016-01-24T13:49:18Z2016-01-24T13:49:18Z2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion67-69http://dx.doi.org/10.1097/SHK.0b013e318181a6e4Shock. Philadelphia: Lippincott Williams & Wilkins, v. 30, p. 67-69, 2008.10.1097/SHK.0b013e318181a6e41073-2322http://repositorio.unifesp.br/handle/11600/30231WOS:000259420600013engShockinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-09-27T09:48:38Zoai:repositorio.unifesp.br/:11600/30231Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-09-27T09:48:38Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
title Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
spellingShingle Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
Camargo, Luis Fernando Aranha [UNIFESP]
Staphylococcus aureus
vancomycin
failure
resistance
title_short Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
title_full Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
title_fullStr Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
title_full_unstemmed Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
title_sort Treatment of severe infections caused by Staphylococcus aureus: A change in the vancomycin paradigm?
author Camargo, Luis Fernando Aranha [UNIFESP]
author_facet Camargo, Luis Fernando Aranha [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
dc.contributor.author.fl_str_mv Camargo, Luis Fernando Aranha [UNIFESP]
dc.subject.por.fl_str_mv Staphylococcus aureus
vancomycin
failure
resistance
topic Staphylococcus aureus
vancomycin
failure
resistance
description Staphylococcus aureus is a frequent agent of serious intensive care unit infections with high associated mortality rates. Resistance to methicillin is frequent, exceeding 50% in many countries, and for these strains, vancomycin is the agent of choice. Resistance to this drug is now frequent for Enterococcus, but low rates are reported for S. aureus. Nonetheless, treatment failures with vancomycin for infections caused by strains considered susceptible have been reported during recent years. This article aims to review the possible explanations for this phenomenon, which is challenging the old paradigm of S. aureus infections and vancomycin use.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2016-01-24T13:49:18Z
2016-01-24T13:49:18Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1097/SHK.0b013e318181a6e4
Shock. Philadelphia: Lippincott Williams & Wilkins, v. 30, p. 67-69, 2008.
10.1097/SHK.0b013e318181a6e4
1073-2322
http://repositorio.unifesp.br/handle/11600/30231
WOS:000259420600013
url http://dx.doi.org/10.1097/SHK.0b013e318181a6e4
http://repositorio.unifesp.br/handle/11600/30231
identifier_str_mv Shock. Philadelphia: Lippincott Williams & Wilkins, v. 30, p. 67-69, 2008.
10.1097/SHK.0b013e318181a6e4
1073-2322
WOS:000259420600013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Shock
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 67-69
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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