MicroRNAs in cancer treatment and prognosis

Detalhes bibliográficos
Autor(a) principal: Schoof, Claudia Regina Gasque [UNIFESP]
Data de Publicação: 2012
Outros Autores: Botelho, Eder Leite da Silva [UNIFESP], Izzotti, Alberto, Vasques, Luciana dos Reis [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://www.ajcr.us/ajcr0000120A.html
http://repositorio.unifesp.br/handle/11600/42251
Resumo: Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.
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spelling MicroRNAs in cancer treatment and prognosisMicroRNAepigenetic modificationsmetastasischemotherapyradiotherapyDisturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.Univ Fed Sao Paulo, Dept Biochem, BR-04044020 Sao Paulo, BrazilUniv Sao Paulo, Dept Genet & Evolutionary Biol, BR-05508090 Sao Paulo, BrazilUniv Genoa, Dept Hlth Sci, I-16132 Genoa, ItalyUniv Fed Sao Paulo, Dept Biochem, BR-04044020 Sao Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Italian Association for Cancer Research (AIRC)Italian Association for Cancer Research (AIRC): 8909E-century Publishing CorpUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Univ GenoaSchoof, Claudia Regina Gasque [UNIFESP]Botelho, Eder Leite da Silva [UNIFESP]Izzotti, AlbertoVasques, Luciana dos Reis [UNIFESP]2018-06-15T12:53:05Z2018-06-15T12:53:05Z2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion414-U136application/pdfhttp://www.ajcr.us/ajcr0000120A.htmlAmerican Journal Of Cancer Research. Madison: E-century Publishing Corp, v. 2, n. 4, p. 414-U136, 2012.WOS000208854800005.pdf2156-6976http://repositorio.unifesp.br/handle/11600/42251WOS:000208854800005engAmerican Journal Of Cancer Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-09T00:55:13Zoai:repositorio.unifesp.br/:11600/42251Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-09T00:55:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv MicroRNAs in cancer treatment and prognosis
title MicroRNAs in cancer treatment and prognosis
spellingShingle MicroRNAs in cancer treatment and prognosis
Schoof, Claudia Regina Gasque [UNIFESP]
MicroRNA
epigenetic modifications
metastasis
chemotherapy
radiotherapy
title_short MicroRNAs in cancer treatment and prognosis
title_full MicroRNAs in cancer treatment and prognosis
title_fullStr MicroRNAs in cancer treatment and prognosis
title_full_unstemmed MicroRNAs in cancer treatment and prognosis
title_sort MicroRNAs in cancer treatment and prognosis
author Schoof, Claudia Regina Gasque [UNIFESP]
author_facet Schoof, Claudia Regina Gasque [UNIFESP]
Botelho, Eder Leite da Silva [UNIFESP]
Izzotti, Alberto
Vasques, Luciana dos Reis [UNIFESP]
author_role author
author2 Botelho, Eder Leite da Silva [UNIFESP]
Izzotti, Alberto
Vasques, Luciana dos Reis [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Genoa
dc.contributor.author.fl_str_mv Schoof, Claudia Regina Gasque [UNIFESP]
Botelho, Eder Leite da Silva [UNIFESP]
Izzotti, Alberto
Vasques, Luciana dos Reis [UNIFESP]
dc.subject.por.fl_str_mv MicroRNA
epigenetic modifications
metastasis
chemotherapy
radiotherapy
topic MicroRNA
epigenetic modifications
metastasis
chemotherapy
radiotherapy
description Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2018-06-15T12:53:05Z
2018-06-15T12:53:05Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ajcr.us/ajcr0000120A.html
American Journal Of Cancer Research. Madison: E-century Publishing Corp, v. 2, n. 4, p. 414-U136, 2012.
WOS000208854800005.pdf
2156-6976
http://repositorio.unifesp.br/handle/11600/42251
WOS:000208854800005
url http://www.ajcr.us/ajcr0000120A.html
http://repositorio.unifesp.br/handle/11600/42251
identifier_str_mv American Journal Of Cancer Research. Madison: E-century Publishing Corp, v. 2, n. 4, p. 414-U136, 2012.
WOS000208854800005.pdf
2156-6976
WOS:000208854800005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv American Journal Of Cancer Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 414-U136
application/pdf
dc.publisher.none.fl_str_mv E-century Publishing Corp
publisher.none.fl_str_mv E-century Publishing Corp
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268338943033344

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