Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://dx.doi.org/10.3390/nu9070692 https://repositorio.unifesp.br/handle/11600/53554 |
Resumo: | This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise. Analysis of Variance (ANOVA) for repeated measures and Tukey post hoc test were performed. Statistical significance was set at p < 0.05. SaO(2)% reduced when comparing baseline vs. pre-exercise, post-exercise, and after recovery for all three groups. There was also a reduction of SaO(2)% in pre-exercise vs. post-exercise for the hypoxia group and an increase was observed in pre-exercise vs. recovery for both supplementation groups, and between post-exercise and for the three groups studied. There was an increase of salivary flow in post-exercise vs. recovery in Hypoxia + Carbohydrate group. Immunoglobulin A (IgA) decreased from baseline vs. post-exercise for Hypoxia + Glutamine group. Interleukin 10 (IL-10) increased from post-exercise vs. after recovery in Hypoxia + Carbohydrate group. Reduction of tumor necrosis factor alpha (TNF-alpha) was observed from baseline vs. post-exercise and after recovery for the Hypoxia + Carbohydrate group a lower concentration was observed in pre-exercise vs. post-exercise and recovery. TNF-alpha had a reduction from baseline vs. post-exercise for both supplementation groups, and a lower secretion between baseline vs. recovery, and pre-exercise vs. post-exercise for Hypoxia + Carbohydrate group. Five hours of hypoxia and exercise did not change IgA. Carbohydrates, with greater efficiency than glutamine, induced anti-inflammatory responses. |
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Caris, Aline Venticinque [UNIFESP]Silva, Edgar Tavares da [UNIFESP]Santos, Samile Amorim dos [UNIFESP]Tufik, Sergio [UNIFESP]Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]2020-06-26T16:30:28Z2020-06-26T16:30:28Z2017https://dx.doi.org/10.3390/nu9070692Nutrients. Basel, v. 9, n. 7, p. -, 2017.2072-6643https://repositorio.unifesp.br/handle/11600/53554WOS000406679700049.pdf10.3390/nu9070692WOS:000406679700049This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise. Analysis of Variance (ANOVA) for repeated measures and Tukey post hoc test were performed. Statistical significance was set at p < 0.05. SaO(2)% reduced when comparing baseline vs. pre-exercise, post-exercise, and after recovery for all three groups. There was also a reduction of SaO(2)% in pre-exercise vs. post-exercise for the hypoxia group and an increase was observed in pre-exercise vs. recovery for both supplementation groups, and between post-exercise and for the three groups studied. There was an increase of salivary flow in post-exercise vs. recovery in Hypoxia + Carbohydrate group. Immunoglobulin A (IgA) decreased from baseline vs. post-exercise for Hypoxia + Glutamine group. Interleukin 10 (IL-10) increased from post-exercise vs. after recovery in Hypoxia + Carbohydrate group. Reduction of tumor necrosis factor alpha (TNF-alpha) was observed from baseline vs. post-exercise and after recovery for the Hypoxia + Carbohydrate group a lower concentration was observed in pre-exercise vs. post-exercise and recovery. TNF-alpha had a reduction from baseline vs. post-exercise for both supplementation groups, and a lower secretion between baseline vs. recovery, and pre-exercise vs. post-exercise for Hypoxia + Carbohydrate group. Five hours of hypoxia and exercise did not change IgA. Carbohydrates, with greater efficiency than glutamine, induced anti-inflammatory responses.Univ Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, BrazilUniv Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, BrazilWeb of Science-engMdpi AgNutrientsSupplementationCarbohydrateHypoxiaPhysical exerciseGlutamineHigh altitudeInnate immune responseOral mucosal immunityEffects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBasel97info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000406679700049.pdfapplication/pdf2007295${dspace.ui.url}/bitstream/11600/53554/1/WOS000406679700049.pdf8cdb3f570e3ef3e26f8b68c5b6dcfbb9MD51open accessTEXTWOS000406679700049.pdf.txtWOS000406679700049.pdf.txtExtracted texttext/plain60872${dspace.ui.url}/bitstream/11600/53554/5/WOS000406679700049.pdf.txt80347734a7b78e5b9511a1151e409538MD55open accessTHUMBNAILWOS000406679700049.pdf.jpgWOS000406679700049.pdf.jpgIM Thumbnailimage/jpeg6902${dspace.ui.url}/bitstream/11600/53554/7/WOS000406679700049.pdf.jpgafe33dd6f9ee24a3e404289ceec283adMD57open access11600/535542023-06-05 19:10:23.825open accessoai:repositorio.unifesp.br:11600/53554Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:10:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
title |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
spellingShingle |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial Caris, Aline Venticinque [UNIFESP] Supplementation Carbohydrate Hypoxia Physical exercise Glutamine High altitude Innate immune response Oral mucosal immunity |
title_short |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
title_full |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
title_fullStr |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
title_full_unstemmed |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
title_sort |
Effects of carbohydrate and glutamine supplementation on oral mucosa immunity after strenuous exercise at high altitude: a double-blind randomized trial |
author |
Caris, Aline Venticinque [UNIFESP] |
author_facet |
Caris, Aline Venticinque [UNIFESP] Silva, Edgar Tavares da [UNIFESP] Santos, Samile Amorim dos [UNIFESP] Tufik, Sergio [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] |
author_role |
author |
author2 |
Silva, Edgar Tavares da [UNIFESP] Santos, Samile Amorim dos [UNIFESP] Tufik, Sergio [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Caris, Aline Venticinque [UNIFESP] Silva, Edgar Tavares da [UNIFESP] Santos, Samile Amorim dos [UNIFESP] Tufik, Sergio [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] |
dc.subject.eng.fl_str_mv |
Supplementation Carbohydrate Hypoxia Physical exercise Glutamine High altitude Innate immune response Oral mucosal immunity |
topic |
Supplementation Carbohydrate Hypoxia Physical exercise Glutamine High altitude Innate immune response Oral mucosal immunity |
description |
This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise. Analysis of Variance (ANOVA) for repeated measures and Tukey post hoc test were performed. Statistical significance was set at p < 0.05. SaO(2)% reduced when comparing baseline vs. pre-exercise, post-exercise, and after recovery for all three groups. There was also a reduction of SaO(2)% in pre-exercise vs. post-exercise for the hypoxia group and an increase was observed in pre-exercise vs. recovery for both supplementation groups, and between post-exercise and for the three groups studied. There was an increase of salivary flow in post-exercise vs. recovery in Hypoxia + Carbohydrate group. Immunoglobulin A (IgA) decreased from baseline vs. post-exercise for Hypoxia + Glutamine group. Interleukin 10 (IL-10) increased from post-exercise vs. after recovery in Hypoxia + Carbohydrate group. Reduction of tumor necrosis factor alpha (TNF-alpha) was observed from baseline vs. post-exercise and after recovery for the Hypoxia + Carbohydrate group a lower concentration was observed in pre-exercise vs. post-exercise and recovery. TNF-alpha had a reduction from baseline vs. post-exercise for both supplementation groups, and a lower secretion between baseline vs. recovery, and pre-exercise vs. post-exercise for Hypoxia + Carbohydrate group. Five hours of hypoxia and exercise did not change IgA. Carbohydrates, with greater efficiency than glutamine, induced anti-inflammatory responses. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-06-26T16:30:28Z |
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2020-06-26T16:30:28Z |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.].fl_str_mv |
https://dx.doi.org/10.3390/nu9070692 |
dc.identifier.citation.fl_str_mv |
Nutrients. Basel, v. 9, n. 7, p. -, 2017. |
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https://repositorio.unifesp.br/handle/11600/53554 |
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2072-6643 |
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WOS000406679700049.pdf |
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10.3390/nu9070692 |
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WOS:000406679700049 |
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https://dx.doi.org/10.3390/nu9070692 https://repositorio.unifesp.br/handle/11600/53554 |
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Nutrients. Basel, v. 9, n. 7, p. -, 2017. 2072-6643 WOS000406679700049.pdf 10.3390/nu9070692 WOS:000406679700049 |
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