Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions

Detalhes bibliográficos
Autor(a) principal: Caris, Aline Venticinque [UNIFESP]
Data de Publicação: 2016
Outros Autores: Silva, Edgar Tavares da [UNIFESP], Santos, Samile Amorim dos [UNIFESP], Lira, Fabio Santos, Oyama, Lila Missae [UNIFESP], Tufik, Sergio [UNIFESP], Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/56823
http://dx.doi.org/10.3390/nu8110706
Resumo: Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditions
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spelling Caris, Aline Venticinque [UNIFESP]Silva, Edgar Tavares da [UNIFESP]Santos, Samile Amorim dos [UNIFESP]Lira, Fabio SantosOyama, Lila Missae [UNIFESP]Tufik, Sergio [UNIFESP]Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]2020-07-31T12:47:25Z2020-07-31T12:47:25Z2016Nutrients. Basel, v. 8, n. 11, p. -, 2016.2072-6643https://repositorio.unifesp.br/handle/11600/56823http://dx.doi.org/10.3390/nu8110706WOS000388666400041.pdf10.3390/nu8110706WOS:000388666400041Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditionsnormoxia, hypoxia and hypoxia + carbohydrate supplementation. Blood samples were collected at rest, at the end of exercise and after 60 min of recovery. To evaluate hypoxia + carbohydrate supplementation, volunteers received a solution of 6% carbohydrate (maltodextrin) or a placebo (strawberry-flavored Crystal Light (R)Kraft Foods, Northfield, IL, USA) every 20 min during exercise and recovery. Statistical analyses comprised analysis of variance, with a one-way ANOVA followed by the Tukey post hoc test with a significance level of p < 0.05. Results: Under normoxic and hypoxic conditions, there was a significant increase in the concentration of IL-6 after exercise and after recovery compared to at rest (p < 0.05), while in the hypoxia + carbohydrate group, there was a significant increase in the concentration of IL-6 and TNF-alpha after exercise compared to at rest (p < 0.05). Furthermore, under this condition, TNF-alpha, IL-2 and the balance of IL-2/IL-4 were increased after recovery compared to at rest (p < 0.05). Conclusion: We conclude that carbohydrate supplementation modified the IL-6 and TNF-alpha serum concentrations and shifted the IL-2/IL-4 balance towards Th1 in response without glycemic, glutaminemia and cell damage effects.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Associação Fundo de Incentivo à Psicofarmacologia (AFIP)Univ Fed Sao Paulo, Dept Psychobiol, BR-04021001 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, BrazilUniv Estadual Paulista, Dept Phys Educ, BR-19060900 Presidente Prudente, BrazilUniv Fed Sao Paulo, Dept Physiol, BR-04021001 Sao Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo 04021-001, BrazilDepartment of Bioscience, Universidade Federal de São Paulo, Santos 11060-001, BrazilDepartment of Physiology, Universidade Federal de São Paulo, São Paulo 04021-001, BrazilFAPESP: 2013/01324-4Web of Science-engMdpi AgNutrientssupplementationcarbohydratehypoxiaexerciseimmune systemIL-2/IL-4Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBasel811info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000388666400041.pdfapplication/pdf238158${dspace.ui.url}/bitstream/11600/56823/1/WOS000388666400041.pdf8172ce646d509b79af1baf481f452259MD51open accessTEXTWOS000388666400041.pdf.txtWOS000388666400041.pdf.txtExtracted texttext/plain40226${dspace.ui.url}/bitstream/11600/56823/5/WOS000388666400041.pdf.txtbafd19cfa8ad659f9a8fdb0ecf9221ecMD55open accessTHUMBNAILWOS000388666400041.pdf.jpgWOS000388666400041.pdf.jpgIM Thumbnailimage/jpeg6754${dspace.ui.url}/bitstream/11600/56823/7/WOS000388666400041.pdf.jpged60b065f8f19cafdad4f904089fc73cMD57open access11600/568232023-06-05 19:12:48.768open accessoai:repositorio.unifesp.br:11600/56823Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:12:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
title Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
spellingShingle Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
Caris, Aline Venticinque [UNIFESP]
supplementation
carbohydrate
hypoxia
exercise
immune system
IL-2/IL-4
title_short Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
title_full Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
title_fullStr Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
title_full_unstemmed Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
title_sort Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions
author Caris, Aline Venticinque [UNIFESP]
author_facet Caris, Aline Venticinque [UNIFESP]
Silva, Edgar Tavares da [UNIFESP]
Santos, Samile Amorim dos [UNIFESP]
Lira, Fabio Santos
Oyama, Lila Missae [UNIFESP]
Tufik, Sergio [UNIFESP]
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
author_role author
author2 Silva, Edgar Tavares da [UNIFESP]
Santos, Samile Amorim dos [UNIFESP]
Lira, Fabio Santos
Oyama, Lila Missae [UNIFESP]
Tufik, Sergio [UNIFESP]
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caris, Aline Venticinque [UNIFESP]
Silva, Edgar Tavares da [UNIFESP]
Santos, Samile Amorim dos [UNIFESP]
Lira, Fabio Santos
Oyama, Lila Missae [UNIFESP]
Tufik, Sergio [UNIFESP]
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.subject.eng.fl_str_mv supplementation
carbohydrate
hypoxia
exercise
immune system
IL-2/IL-4
topic supplementation
carbohydrate
hypoxia
exercise
immune system
IL-2/IL-4
description Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditions
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-07-31T12:47:25Z
dc.date.available.fl_str_mv 2020-07-31T12:47:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv Nutrients. Basel, v. 8, n. 11, p. -, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/56823
http://dx.doi.org/10.3390/nu8110706
dc.identifier.issn.none.fl_str_mv 2072-6643
dc.identifier.file.none.fl_str_mv WOS000388666400041.pdf
dc.identifier.doi.none.fl_str_mv 10.3390/nu8110706
dc.identifier.wos.none.fl_str_mv WOS:000388666400041
identifier_str_mv Nutrients. Basel, v. 8, n. 11, p. -, 2016.
2072-6643
WOS000388666400041.pdf
10.3390/nu8110706
WOS:000388666400041
url https://repositorio.unifesp.br/handle/11600/56823
http://dx.doi.org/10.3390/nu8110706
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dc.coverage.none.fl_str_mv Basel
dc.publisher.none.fl_str_mv Mdpi Ag
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
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institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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