Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos

Detalhes bibliográficos
Autor(a) principal: Tiago, Romualdo Suzano Louzeiro [UNIFESP]
Data de Publicação: 2005
Outros Autores: Faria, Flavio Paulo de [UNIFESP], Pontes, Paulo Augusto de Lima [UNIFESP], Brasil, Osíris de Oliveira Camponês do [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0034-72992005000500002
http://repositorio.unifesp.br/handle/11600/2734
Resumo: AIM: Perform a morphometric analysis of the myelinic fibers of the right hypoglossal nerve, in two age groups; to verify quantitative changes as a result of the aging process. STUDY DESIGN: anatomic. MATERIAL AND METHOD: A 1cm fragment of the right hypoglossal nerve was collected from 12 male corpses without any medical history of diseases such as: diabetes, alcoholism, and malignant neoplasia. The sample was divided in two groups: group with six corpses under sixty years old (adult), and another group with six corpses sixty years old or above (elderly). The material was fixed at 2.5% glutaldehyde and 2% paraformaldehyde solution; post-fixed at 2% osmium tetroxide; dehydrated with increasing ethanol concentrations, and included in epoxy resin. Semi-thin sections of 0.3µm were obtaining, colored in 1% toluidine blue, and evaluated with light microscope combined with image analyzing system. The following morphometric data were quantified: intraperineural transversal section area, number, and diameter of the myelinic fibers. RESULTS: The intraperineural area of the hypoglossal nerve was similar in both age groups (p=0.8691). The average area in the adult group was 1.697mm² and in the elderly group it was 1.649mm². The total number of myelinic fibers of the hypoglossal nerve was similar in both age groups (p=0.9018). The adult group presented an average of 10,286 ± 2,308 myelinic fibers, and the elderly group presented an average of 10,141 ± 1,590 myelinic fibers. A bimodal distribution of the myelinic fibers was observed, with a significant peak on the 9µm fibers, and another smaller peak on the 2µm fibers. CONCLUSION: The intraperineural area and the total number of myelinic fibers of the right hypoglossal nerve are similar in both age groups.
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spelling Aspectos morfométricos do nervo hipoglosso humano em adultos e idososMorphometric aspects of the human hypoglossal nerve in adults and the elderlyhypoglossal nerveagingdysphagianervo hipoglossoenvelhecimentodisfagiaAIM: Perform a morphometric analysis of the myelinic fibers of the right hypoglossal nerve, in two age groups; to verify quantitative changes as a result of the aging process. STUDY DESIGN: anatomic. MATERIAL AND METHOD: A 1cm fragment of the right hypoglossal nerve was collected from 12 male corpses without any medical history of diseases such as: diabetes, alcoholism, and malignant neoplasia. The sample was divided in two groups: group with six corpses under sixty years old (adult), and another group with six corpses sixty years old or above (elderly). The material was fixed at 2.5% glutaldehyde and 2% paraformaldehyde solution; post-fixed at 2% osmium tetroxide; dehydrated with increasing ethanol concentrations, and included in epoxy resin. Semi-thin sections of 0.3µm were obtaining, colored in 1% toluidine blue, and evaluated with light microscope combined with image analyzing system. The following morphometric data were quantified: intraperineural transversal section area, number, and diameter of the myelinic fibers. RESULTS: The intraperineural area of the hypoglossal nerve was similar in both age groups (p=0.8691). The average area in the adult group was 1.697mm² and in the elderly group it was 1.649mm². The total number of myelinic fibers of the hypoglossal nerve was similar in both age groups (p=0.9018). The adult group presented an average of 10,286 ± 2,308 myelinic fibers, and the elderly group presented an average of 10,141 ± 1,590 myelinic fibers. A bimodal distribution of the myelinic fibers was observed, with a significant peak on the 9µm fibers, and another smaller peak on the 2µm fibers. CONCLUSION: The intraperineural area and the total number of myelinic fibers of the right hypoglossal nerve are similar in both age groups.OBJETIVO: Realizar análise morfométrica das fibras mielínicas do nervo hipoglosso direito, em dois grupos etários, com a finalidade de verificar modificações quantitativas decorrentes do processo de envelhecimento. FORMA DE ESTUDO: anatômico. MATERIAL E MÉTODO: Foi coletado fragmento de 1cm do nervo hipoglosso direito de 12 cadáveres do sexo masculino, sem antecedentes para doenças como diabetes, alcoolismo e neoplasia maligna. A amostra foi dividida em dois grupos: grupo adulto (idade inferior a 60 anos), composto por seis cadáveres; grupo idoso (idade igual ou superior a 60 anos), composto por seis cadáveres. O material foi fixado em solução contendo 2,5% de glutaraldeído e 2% de paraformaldeído; pós-fixado em tetróxido de ósmio 2%; desidratado em concentrações crescentes de etanol e incluído em resina epóxi. Cortes semifinos de 0,3¼m de espessura foram obtidos, corados com azul de toluidina a 1% e avaliados em microscópio de luz acoplado a sistema analisador de imagens. Os seguintes dados morfométricos foram quantificados: área de secção transversal intraperineural, número e o diâmetro das fibras mielínicas. RESULTADOS: A área intraperineural do nervo hipoglosso foi semelhante nos dois grupos etários (p=0,8691). A média da área no grupo adulto foi de 1,697 mm2, e no grupo idoso foi de 1,649 mm2. O número total de fibras mielínicas do nervo hipoglosso foi semelhante nos dois grupos etários (p=0,9018). O grupo adulto apresentou média de 10.286 ± 2308 fibras mielínicas e o grupo idoso apresentou média de 10.141 ± 1590 fibras mielínicas. Foi observada distribuição bimodal das fibras mielínicas, com pico acentuado nas fibras de 9¼m e outro menor nas fibras de 2¼m. CONCLUSÃO: A área intraperineural e o número total de fibras mielínicas do nervo hipoglosso direito é semelhante nos dois grupos etários.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPM, Depto. de Otorrinolaringologia e Cirurgia de Cabeça e PescoçoUNIFESP, EPMSciELOABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-FacialUniversidade Federal de São Paulo (UNIFESP)Tiago, Romualdo Suzano Louzeiro [UNIFESP]Faria, Flavio Paulo de [UNIFESP]Pontes, Paulo Augusto de Lima [UNIFESP]Brasil, Osíris de Oliveira Camponês do [UNIFESP]2015-06-14T13:31:46Z2015-06-14T13:31:46Z2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion554-558application/pdfhttp://dx.doi.org/10.1590/S0034-72992005000500002Revista Brasileira de Otorrinolaringologia. ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, v. 71, n. 5, p. 554-558, 2005.10.1590/S0034-72992005000500002S0034-72992005000500002.pdf0034-7299S0034-72992005000500002http://repositorio.unifesp.br/handle/11600/2734porRevista Brasileira de Otorrinolaringologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T19:29:40Zoai:repositorio.unifesp.br/:11600/2734Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T19:29:40Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
Morphometric aspects of the human hypoglossal nerve in adults and the elderly
title Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
spellingShingle Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
Tiago, Romualdo Suzano Louzeiro [UNIFESP]
hypoglossal nerve
aging
dysphagia
nervo hipoglosso
envelhecimento
disfagia
title_short Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
title_full Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
title_fullStr Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
title_full_unstemmed Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
title_sort Aspectos morfométricos do nervo hipoglosso humano em adultos e idosos
author Tiago, Romualdo Suzano Louzeiro [UNIFESP]
author_facet Tiago, Romualdo Suzano Louzeiro [UNIFESP]
Faria, Flavio Paulo de [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osíris de Oliveira Camponês do [UNIFESP]
author_role author
author2 Faria, Flavio Paulo de [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osíris de Oliveira Camponês do [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Tiago, Romualdo Suzano Louzeiro [UNIFESP]
Faria, Flavio Paulo de [UNIFESP]
Pontes, Paulo Augusto de Lima [UNIFESP]
Brasil, Osíris de Oliveira Camponês do [UNIFESP]
dc.subject.por.fl_str_mv hypoglossal nerve
aging
dysphagia
nervo hipoglosso
envelhecimento
disfagia
topic hypoglossal nerve
aging
dysphagia
nervo hipoglosso
envelhecimento
disfagia
description AIM: Perform a morphometric analysis of the myelinic fibers of the right hypoglossal nerve, in two age groups; to verify quantitative changes as a result of the aging process. STUDY DESIGN: anatomic. MATERIAL AND METHOD: A 1cm fragment of the right hypoglossal nerve was collected from 12 male corpses without any medical history of diseases such as: diabetes, alcoholism, and malignant neoplasia. The sample was divided in two groups: group with six corpses under sixty years old (adult), and another group with six corpses sixty years old or above (elderly). The material was fixed at 2.5% glutaldehyde and 2% paraformaldehyde solution; post-fixed at 2% osmium tetroxide; dehydrated with increasing ethanol concentrations, and included in epoxy resin. Semi-thin sections of 0.3µm were obtaining, colored in 1% toluidine blue, and evaluated with light microscope combined with image analyzing system. The following morphometric data were quantified: intraperineural transversal section area, number, and diameter of the myelinic fibers. RESULTS: The intraperineural area of the hypoglossal nerve was similar in both age groups (p=0.8691). The average area in the adult group was 1.697mm² and in the elderly group it was 1.649mm². The total number of myelinic fibers of the hypoglossal nerve was similar in both age groups (p=0.9018). The adult group presented an average of 10,286 ± 2,308 myelinic fibers, and the elderly group presented an average of 10,141 ± 1,590 myelinic fibers. A bimodal distribution of the myelinic fibers was observed, with a significant peak on the 9µm fibers, and another smaller peak on the 2µm fibers. CONCLUSION: The intraperineural area and the total number of myelinic fibers of the right hypoglossal nerve are similar in both age groups.
publishDate 2005
dc.date.none.fl_str_mv 2005-10-01
2015-06-14T13:31:46Z
2015-06-14T13:31:46Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0034-72992005000500002
Revista Brasileira de Otorrinolaringologia. ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, v. 71, n. 5, p. 554-558, 2005.
10.1590/S0034-72992005000500002
S0034-72992005000500002.pdf
0034-7299
S0034-72992005000500002
http://repositorio.unifesp.br/handle/11600/2734
url http://dx.doi.org/10.1590/S0034-72992005000500002
http://repositorio.unifesp.br/handle/11600/2734
identifier_str_mv Revista Brasileira de Otorrinolaringologia. ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, v. 71, n. 5, p. 554-558, 2005.
10.1590/S0034-72992005000500002
S0034-72992005000500002.pdf
0034-7299
S0034-72992005000500002
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Otorrinolaringologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 554-558
application/pdf
dc.publisher.none.fl_str_mv ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
publisher.none.fl_str_mv ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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