Nicotine on rat TRAM flap

Detalhes bibliográficos
Autor(a) principal: Ely, Pedro Bins
Data de Publicação: 2009
Outros Autores: Kobayashi, Ludmila Aimi [UNIFESP], Campos, José Humberto Oliveira, Gomes, Heitor Carvalho [UNIFESP], Juliano, Yara [UNIFESP], Ferreira, Lydia Masako [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502009000300010
http://repositorio.unifesp.br/handle/11600/5055
Resumo: PURPOSE: The transverse rectus abdominis myocutaneous (TRAM) flap is one of the preferential techniques used in breast reconstruction following mastectomy. Nicotine has a detrimental effect on cutaneous flap survival; although there are no experimental studies proving this effect on musculocutaneous flaps. The aim of this study is to verify the effect of nicotine on the rat TRAM flap. METHODS: 30 Wistar EPM-1 rats were randomly distributed in two groups: control and experimental. The animals of the control group received saline solution injected subcutaneously, in a volume of 0.2 ml, twice a day, during 28 days in the preoperative period. The animals of the experimental group were treated with nicotine, injected subcutaneously, in a dose of 2 mg/kg twice a day, during 28 days in the preoperative period. All the animals were submitted to the caudally based, right unipedicled TRAM flap. 48 hours after the procedure, a study of the viable area of the flap was done through photographic documentation. Statistical analysis was performed with nonparametric Mann-Whitney's test. RESULTS: The experimental group had significantly greater area of necrosis when compared with the control group (p<0.001). CONCLUSION: Nicotine increased the area of necrosis of the TRAM flap, in rats.
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spelling Nicotine on rat TRAM flapNicotina em retalho TRAM em ratosSurgical FlapsNicotineRectus AbdominisSurgery, PlasticRatsRetalhos CirúrgicosNicotinaReto do AbdomeCirurgia PlásticaRatosPURPOSE: The transverse rectus abdominis myocutaneous (TRAM) flap is one of the preferential techniques used in breast reconstruction following mastectomy. Nicotine has a detrimental effect on cutaneous flap survival; although there are no experimental studies proving this effect on musculocutaneous flaps. The aim of this study is to verify the effect of nicotine on the rat TRAM flap. METHODS: 30 Wistar EPM-1 rats were randomly distributed in two groups: control and experimental. The animals of the control group received saline solution injected subcutaneously, in a volume of 0.2 ml, twice a day, during 28 days in the preoperative period. The animals of the experimental group were treated with nicotine, injected subcutaneously, in a dose of 2 mg/kg twice a day, during 28 days in the preoperative period. All the animals were submitted to the caudally based, right unipedicled TRAM flap. 48 hours after the procedure, a study of the viable area of the flap was done through photographic documentation. Statistical analysis was performed with nonparametric Mann-Whitney's test. RESULTS: The experimental group had significantly greater area of necrosis when compared with the control group (p<0.001). CONCLUSION: Nicotine increased the area of necrosis of the TRAM flap, in rats.OBJETIVOS: O retalho musculocutâneo transverso do músculo reto do abdome (TRAM) é uma das principais opções na reconstrução do relevo mamário pós-mastectomia. A nicotina tem efeito deletério na viabilidade de retalhos cutâneos; porém, não foram encontrados trabalhos experimentais comprovando este efeito em retalhos musculocutâneos. O objetivo deste trabalho é investigar o efeito da nicotina na viabilidade do retalho TRAM, em ratos. MÉTODOS: Foram utilizados 30 ratos da linhagem Wistar EPM-1. Os animais foram distribuídos aleatoriamente em dois grupos: controle e experimento. Os animais do grupo controle foram tratados com solução salina injetada no tecido celular subcutâneo num volume de 0,2 ml, duas vezes ao dia, durante 28 dias no período pré-operatório. Os animais do grupo experimento foram tratados com nicotina injetada no tecido celular subcutâneo em uma dose de 2mg/kg/2 vezes ao dia, durante 28 dias no período pré-operatório. Todos os animais foram submetidos ao procedimento do retalho TRAM de base caudal unilateral à direita (pedículo não dominante). 48 horas depois, foi feita a avaliação da área viável de superfície do retalho, por documentação fotográfica. Para análise dos resultados foram utilizados testes não paramétricos: Mann-Whitney. RESULTADOS: O grupo experimento apresentou uma área de necrose maior, quando comparado com o grupo controle (p<0,001). CONCLUSÃO: A nicotina aumentou a área de necrose do retalho TRAM, em ratos.Unit Santa Casa de Porto Alegre Plastic SurgeryUniversidade Federal de São Paulo (UNIFESP) Department of Surgery Plastic Surgery DivisionEscola Bahiana de Medicina Department of Surgery Head of Operative Technique and Experimental Surgery DivisionUniversidade Federal de São Paulo (UNIFESP) Department of EpidemiologyUniversidade Federal de São Paulo (UNIFESP) Department of Surgery Head of Plastic Surgery Division and ChairwomanUNIFESP, Department of Surgery Plastic Surgery DivisionUNIFESP, Department of EpidemiologyUNIFESP, Department of Surgery Head of Plastic Surgery Division and ChairwomanSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUnit Santa Casa de Porto Alegre Plastic SurgeryUniversidade Federal de São Paulo (UNIFESP)Escola Bahiana de Medicina Department of Surgery Head of Operative Technique and Experimental Surgery DivisionEly, Pedro BinsKobayashi, Ludmila Aimi [UNIFESP]Campos, José Humberto OliveiraGomes, Heitor Carvalho [UNIFESP]Juliano, Yara [UNIFESP]Ferreira, Lydia Masako [UNIFESP]2015-06-14T13:39:13Z2015-06-14T13:39:13Z2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion216-220application/pdfhttp://dx.doi.org/10.1590/S0102-86502009000300010Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 24, n. 3, p. 216-220, 2009.10.1590/S0102-86502009000300010S0102-86502009000300010.pdf0102-8650S0102-86502009000300010http://repositorio.unifesp.br/handle/11600/5055WOS:000266785400010engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T22:13:39Zoai:repositorio.unifesp.br/:11600/5055Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T22:13:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Nicotine on rat TRAM flap
Nicotina em retalho TRAM em ratos
title Nicotine on rat TRAM flap
spellingShingle Nicotine on rat TRAM flap
Ely, Pedro Bins
Surgical Flaps
Nicotine
Rectus Abdominis
Surgery, Plastic
Rats
Retalhos Cirúrgicos
Nicotina
Reto do Abdome
Cirurgia Plástica
Ratos
title_short Nicotine on rat TRAM flap
title_full Nicotine on rat TRAM flap
title_fullStr Nicotine on rat TRAM flap
title_full_unstemmed Nicotine on rat TRAM flap
title_sort Nicotine on rat TRAM flap
author Ely, Pedro Bins
author_facet Ely, Pedro Bins
Kobayashi, Ludmila Aimi [UNIFESP]
Campos, José Humberto Oliveira
Gomes, Heitor Carvalho [UNIFESP]
Juliano, Yara [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
author_role author
author2 Kobayashi, Ludmila Aimi [UNIFESP]
Campos, José Humberto Oliveira
Gomes, Heitor Carvalho [UNIFESP]
Juliano, Yara [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Unit Santa Casa de Porto Alegre Plastic Surgery
Universidade Federal de São Paulo (UNIFESP)
Escola Bahiana de Medicina Department of Surgery Head of Operative Technique and Experimental Surgery Division
dc.contributor.author.fl_str_mv Ely, Pedro Bins
Kobayashi, Ludmila Aimi [UNIFESP]
Campos, José Humberto Oliveira
Gomes, Heitor Carvalho [UNIFESP]
Juliano, Yara [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
dc.subject.por.fl_str_mv Surgical Flaps
Nicotine
Rectus Abdominis
Surgery, Plastic
Rats
Retalhos Cirúrgicos
Nicotina
Reto do Abdome
Cirurgia Plástica
Ratos
topic Surgical Flaps
Nicotine
Rectus Abdominis
Surgery, Plastic
Rats
Retalhos Cirúrgicos
Nicotina
Reto do Abdome
Cirurgia Plástica
Ratos
description PURPOSE: The transverse rectus abdominis myocutaneous (TRAM) flap is one of the preferential techniques used in breast reconstruction following mastectomy. Nicotine has a detrimental effect on cutaneous flap survival; although there are no experimental studies proving this effect on musculocutaneous flaps. The aim of this study is to verify the effect of nicotine on the rat TRAM flap. METHODS: 30 Wistar EPM-1 rats were randomly distributed in two groups: control and experimental. The animals of the control group received saline solution injected subcutaneously, in a volume of 0.2 ml, twice a day, during 28 days in the preoperative period. The animals of the experimental group were treated with nicotine, injected subcutaneously, in a dose of 2 mg/kg twice a day, during 28 days in the preoperative period. All the animals were submitted to the caudally based, right unipedicled TRAM flap. 48 hours after the procedure, a study of the viable area of the flap was done through photographic documentation. Statistical analysis was performed with nonparametric Mann-Whitney's test. RESULTS: The experimental group had significantly greater area of necrosis when compared with the control group (p<0.001). CONCLUSION: Nicotine increased the area of necrosis of the TRAM flap, in rats.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
2015-06-14T13:39:13Z
2015-06-14T13:39:13Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502009000300010
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 24, n. 3, p. 216-220, 2009.
10.1590/S0102-86502009000300010
S0102-86502009000300010.pdf
0102-8650
S0102-86502009000300010
http://repositorio.unifesp.br/handle/11600/5055
WOS:000266785400010
url http://dx.doi.org/10.1590/S0102-86502009000300010
http://repositorio.unifesp.br/handle/11600/5055
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 24, n. 3, p. 216-220, 2009.
10.1590/S0102-86502009000300010
S0102-86502009000300010.pdf
0102-8650
S0102-86502009000300010
WOS:000266785400010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 216-220
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268454055706624

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