Cytogenetic study of women with premature ovarian failure

Detalhes bibliográficos
Autor(a) principal: Pagni, Denise [UNIFESP]
Data de Publicação: 1998
Outros Autores: Melaragno, Maria Isabel [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1415-47571998000200016
http://repositorio.unifesp.br/handle/11600/638
Resumo: Etiology of premature ovarian failure (POF) is unclear in most patients. Since some cases are related to X-chromosome abnormalities, cytogenetical studies were conducted in patients with POF. Lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. All individuals presented normal karyotypes. Frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. The X chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
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spelling Cytogenetic study of women with premature ovarian failureEtiology of premature ovarian failure (POF) is unclear in most patients. Since some cases are related to X-chromosome abnormalities, cytogenetical studies were conducted in patients with POF. Lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. All individuals presented normal karyotypes. Frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. The X chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.A etiologia da insuficiência ovariana prematura (POF) ainda é desconhecida na maioria dos pacientes. Uma vez que alguns casos estão associados a anormalidades do cromossomo X, estudamos citogeneticamente pacientes portadores de POF. Comparamos as culturas de linfócitos de onze pacientes com as de indivíduos controles de mesmas idades. Todos os indivíduos estudados apresentaram cariótipos normais. As freqüências de células aneuplóides e com aberrações cromossômicas estruturais não diferiram entre os grupos. Verificamos uma maior freqüência de aneuploidia e de divisão prematura do centrômero do cromossomo X nos dois grupos.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciELOSociedade Brasileira de GenéticaUniversidade Federal de São Paulo (UNIFESP)Pagni, Denise [UNIFESP]Melaragno, Maria Isabel [UNIFESP]2015-06-14T13:24:44Z2015-06-14T13:24:44Z1998-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion263-266application/pdfhttp://dx.doi.org/10.1590/S1415-47571998000200016Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 21, n. 2, p. 263-266, 1998.10.1590/S1415-47571998000200016S1415-47571998000200016.pdf1415-4757S1415-47571998000200016http://repositorio.unifesp.br/handle/11600/638WOS:000075463600016engGenetics and Molecular Biologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T21:59:27Zoai:repositorio.unifesp.br/:11600/638Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T21:59:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cytogenetic study of women with premature ovarian failure
title Cytogenetic study of women with premature ovarian failure
spellingShingle Cytogenetic study of women with premature ovarian failure
Pagni, Denise [UNIFESP]
title_short Cytogenetic study of women with premature ovarian failure
title_full Cytogenetic study of women with premature ovarian failure
title_fullStr Cytogenetic study of women with premature ovarian failure
title_full_unstemmed Cytogenetic study of women with premature ovarian failure
title_sort Cytogenetic study of women with premature ovarian failure
author Pagni, Denise [UNIFESP]
author_facet Pagni, Denise [UNIFESP]
Melaragno, Maria Isabel [UNIFESP]
author_role author
author2 Melaragno, Maria Isabel [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pagni, Denise [UNIFESP]
Melaragno, Maria Isabel [UNIFESP]
description Etiology of premature ovarian failure (POF) is unclear in most patients. Since some cases are related to X-chromosome abnormalities, cytogenetical studies were conducted in patients with POF. Lymphocyte cultures from eleven patients were compared to cultures from age-matched controls. All individuals presented normal karyotypes. Frequencies of aneuploid and structural chromosome aberrations did not differ between the groups. The X chromosome was more frequently involved in aneuploidy and in premature centromere division in both groups.
publishDate 1998
dc.date.none.fl_str_mv 1998-06-01
2015-06-14T13:24:44Z
2015-06-14T13:24:44Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1415-47571998000200016
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 21, n. 2, p. 263-266, 1998.
10.1590/S1415-47571998000200016
S1415-47571998000200016.pdf
1415-4757
S1415-47571998000200016
http://repositorio.unifesp.br/handle/11600/638
WOS:000075463600016
url http://dx.doi.org/10.1590/S1415-47571998000200016
http://repositorio.unifesp.br/handle/11600/638
identifier_str_mv Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 21, n. 2, p. 263-266, 1998.
10.1590/S1415-47571998000200016
S1415-47571998000200016.pdf
1415-4757
S1415-47571998000200016
WOS:000075463600016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics and Molecular Biology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 263-266
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268405193113600

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