Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder

Detalhes bibliográficos
Autor(a) principal: Martins Okuda, Paola Matiko [UNIFESP]
Data de Publicação: 2017
Outros Autores: Klaiman, Cheryl, Bradshaw, Jessica, Reid, Morganne, Cogo-Moreira, Hugo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000019xbz
DOI: 10.3389/fpsyt.2017.00265
Texto Completo: http://dx.doi.org/10.3389/fpsyt.2017.00265
https://repositorio.unifesp.br/handle/11600/58159
Resumo: Aim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (omega = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.
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spelling Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorderautism spectrum disorderrisk of biasconfirmatory factor analysismeta-analysisrandomized controlled trialsAim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (omega = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, BrazilChildrens Healthcare Atlanta, Marcus Autism Ctr, Atlanta, GA USAEmory Univ, Sch Med, Atlanta, GA USAUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, BrazilWeb of ScienceSao Paulo Research Foundation-FAPESPFAPESP: 2015/04619-0Frontiers Media Sa2020-09-01T13:21:16Z2020-09-01T13:21:16Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fpsyt.2017.00265Frontiers In Psychiatry. Lausanne, v. 8, p. -, 2017.10.3389/fpsyt.2017.00265WOS000416410200001.pdf1664-0640https://repositorio.unifesp.br/handle/11600/58159WOS:000416410200001ark:/48912/0013000019xbzengFrontiers In PsychiatryLausanneinfo:eu-repo/semantics/openAccessMartins Okuda, Paola Matiko [UNIFESP]Klaiman, CherylBradshaw, JessicaReid, MorganneCogo-Moreira, Hugo [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-09T13:42:35Zoai:repositorio.unifesp.br/:11600/58159Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:06:23.872403Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
title Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
spellingShingle Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
Martins Okuda, Paola Matiko [UNIFESP]
autism spectrum disorder
risk of bias
confirmatory factor analysis
meta-analysis
randomized controlled trials
Martins Okuda, Paola Matiko [UNIFESP]
autism spectrum disorder
risk of bias
confirmatory factor analysis
meta-analysis
randomized controlled trials
title_short Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
title_full Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
title_fullStr Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
title_full_unstemmed Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
title_sort Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder
author Martins Okuda, Paola Matiko [UNIFESP]
author_facet Martins Okuda, Paola Matiko [UNIFESP]
Martins Okuda, Paola Matiko [UNIFESP]
Klaiman, Cheryl
Bradshaw, Jessica
Reid, Morganne
Cogo-Moreira, Hugo [UNIFESP]
Klaiman, Cheryl
Bradshaw, Jessica
Reid, Morganne
Cogo-Moreira, Hugo [UNIFESP]
author_role author
author2 Klaiman, Cheryl
Bradshaw, Jessica
Reid, Morganne
Cogo-Moreira, Hugo [UNIFESP]
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Martins Okuda, Paola Matiko [UNIFESP]
Klaiman, Cheryl
Bradshaw, Jessica
Reid, Morganne
Cogo-Moreira, Hugo [UNIFESP]
dc.subject.por.fl_str_mv autism spectrum disorder
risk of bias
confirmatory factor analysis
meta-analysis
randomized controlled trials
topic autism spectrum disorder
risk of bias
confirmatory factor analysis
meta-analysis
randomized controlled trials
description Aim: To determine construct validity and reliability indicators of the Cochrane risk of bias (RoB) tool in the context of randomized clinical trials (RCTs) for autism spectrum disorder (ASD). Methods: Confirmatory factor analysis was used to evaluate a unidimensional model consisting of 9 RoB categorical indicators evaluated across 94 RCTs addressing interventions for ASD. Results: Only five of the nine original RoB items returned good fit indices and so were retained in the analysis. Only one of this five had very high factor loadings. The remaining four indicators had more measurement error than common variance with the RoB latent factor. Together, the five indicators showed poor reliability (omega = 0.687; 95% CI: 0.613-0.761). Conclusion: Although the Cochrane model of RoB for ASD exhibited good fit indices, the majorities of the items have more residual variance than common variance and, therefore, did not adequately capture the RoB in ASD intervention trials.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-09-01T13:21:16Z
2020-09-01T13:21:16Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fpsyt.2017.00265
Frontiers In Psychiatry. Lausanne, v. 8, p. -, 2017.
10.3389/fpsyt.2017.00265
WOS000416410200001.pdf
1664-0640
https://repositorio.unifesp.br/handle/11600/58159
WOS:000416410200001
dc.identifier.dark.fl_str_mv ark:/48912/0013000019xbz
url http://dx.doi.org/10.3389/fpsyt.2017.00265
https://repositorio.unifesp.br/handle/11600/58159
identifier_str_mv Frontiers In Psychiatry. Lausanne, v. 8, p. -, 2017.
10.3389/fpsyt.2017.00265
WOS000416410200001.pdf
1664-0640
WOS:000416410200001
ark:/48912/0013000019xbz
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers In Psychiatry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv Lausanne
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822219244667928577
dc.identifier.doi.none.fl_str_mv 10.3389/fpsyt.2017.00265

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