Effects of acute and chronic sleep loss on immune modulation of rats
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/29834 https://dx.doi.org/10.1152/ajpregu.00105.2007 |
Resumo: | Sleep deprivation is now recognized as an increasingly common condition inherent to modern society, and one that in many ways, is detrimental to certain physiological systems, namely, immune function. Although sleep is now viewed by a significant body of researchers as being essential for the proper working of a host of defense systems, the consequences of a lack of sleep on immune function remains to be fully comprehended. the aim of the current study was to investigate how paradoxical sleep deprivation (PSD) for 24 and 96 h and sleep restriction (SR) for 21 days by the modified multiple-platform method, and their respective 24-h recovery periods, affect immune activation in rats. To this end, we assessed circulating white blood cell counts, lymphocyte count within immune organs, as well as Ig and complement production. the data revealed that PSD for 96 h increased complement C3 and corticosterone concentration in relation to the control group. in contrast, the spleen weight, total leukocytes, and lymphocytes decreased during SR for 21 days when compared with the control group, although production of a certain class of immunoglobulin, the IgM, did increase. After recovery sleep, lymphocyte count in axillary lymph nodes grew when rats had rebound sleep after PSD for 24 h, neutrophils increased after PSD 96 h and lymphocytes numbers were higher after SR 21 days. Such alterations during sleep deprivation suggest only minor alterations of nonspecific immune parameters during acute PSD, and a significant impairment in cellular response during chronic SR. |
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Zager, Adriano [UNIFESP]Andersen, Monica Levy [UNIFESP]Ruiz, Francieli Silva [UNIFESP]Antunes, Isabela B. [UNIFESP]Tufik, Sergio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T13:48:49Z2016-01-24T13:48:49Z2007-07-01American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 293, n. 1, p. R504-R509, 2007.0363-6119https://repositorio.unifesp.br/handle/11600/29834https://dx.doi.org/10.1152/ajpregu.00105.200710.1152/ajpregu.00105.2007WOS:000247970700058Sleep deprivation is now recognized as an increasingly common condition inherent to modern society, and one that in many ways, is detrimental to certain physiological systems, namely, immune function. Although sleep is now viewed by a significant body of researchers as being essential for the proper working of a host of defense systems, the consequences of a lack of sleep on immune function remains to be fully comprehended. the aim of the current study was to investigate how paradoxical sleep deprivation (PSD) for 24 and 96 h and sleep restriction (SR) for 21 days by the modified multiple-platform method, and their respective 24-h recovery periods, affect immune activation in rats. To this end, we assessed circulating white blood cell counts, lymphocyte count within immune organs, as well as Ig and complement production. the data revealed that PSD for 96 h increased complement C3 and corticosterone concentration in relation to the control group. in contrast, the spleen weight, total leukocytes, and lymphocytes decreased during SR for 21 days when compared with the control group, although production of a certain class of immunoglobulin, the IgM, did increase. After recovery sleep, lymphocyte count in axillary lymph nodes grew when rats had rebound sleep after PSD for 24 h, neutrophils increased after PSD 96 h and lymphocytes numbers were higher after SR 21 days. Such alterations during sleep deprivation suggest only minor alterations of nonspecific immune parameters during acute PSD, and a significant impairment in cellular response during chronic SR.Associação Fundo de Incentivo à Psicofarmacologia (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilFAPESP: 98/14303-3FAPESP: 04/03979-9Web of ScienceR504-R509engAmer Physiological SocAmerican Journal of Physiology-regulatory Integrative and Comparative PhysiologySleep deprivationImmune systemHost defensesLeukocytesImmuno-globulinEffects of acute and chronic sleep loss on immune modulation of ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/298342021-10-05 21:26:34.433metadata only accessoai:repositorio.unifesp.br:11600/29834Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:26:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of acute and chronic sleep loss on immune modulation of rats |
title |
Effects of acute and chronic sleep loss on immune modulation of rats |
spellingShingle |
Effects of acute and chronic sleep loss on immune modulation of rats Zager, Adriano [UNIFESP] Sleep deprivation Immune system Host defenses Leukocytes Immuno-globulin |
title_short |
Effects of acute and chronic sleep loss on immune modulation of rats |
title_full |
Effects of acute and chronic sleep loss on immune modulation of rats |
title_fullStr |
Effects of acute and chronic sleep loss on immune modulation of rats |
title_full_unstemmed |
Effects of acute and chronic sleep loss on immune modulation of rats |
title_sort |
Effects of acute and chronic sleep loss on immune modulation of rats |
author |
Zager, Adriano [UNIFESP] |
author_facet |
Zager, Adriano [UNIFESP] Andersen, Monica Levy [UNIFESP] Ruiz, Francieli Silva [UNIFESP] Antunes, Isabela B. [UNIFESP] Tufik, Sergio [UNIFESP] |
author_role |
author |
author2 |
Andersen, Monica Levy [UNIFESP] Ruiz, Francieli Silva [UNIFESP] Antunes, Isabela B. [UNIFESP] Tufik, Sergio [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Zager, Adriano [UNIFESP] Andersen, Monica Levy [UNIFESP] Ruiz, Francieli Silva [UNIFESP] Antunes, Isabela B. [UNIFESP] Tufik, Sergio [UNIFESP] |
dc.subject.eng.fl_str_mv |
Sleep deprivation Immune system Host defenses Leukocytes Immuno-globulin |
topic |
Sleep deprivation Immune system Host defenses Leukocytes Immuno-globulin |
description |
Sleep deprivation is now recognized as an increasingly common condition inherent to modern society, and one that in many ways, is detrimental to certain physiological systems, namely, immune function. Although sleep is now viewed by a significant body of researchers as being essential for the proper working of a host of defense systems, the consequences of a lack of sleep on immune function remains to be fully comprehended. the aim of the current study was to investigate how paradoxical sleep deprivation (PSD) for 24 and 96 h and sleep restriction (SR) for 21 days by the modified multiple-platform method, and their respective 24-h recovery periods, affect immune activation in rats. To this end, we assessed circulating white blood cell counts, lymphocyte count within immune organs, as well as Ig and complement production. the data revealed that PSD for 96 h increased complement C3 and corticosterone concentration in relation to the control group. in contrast, the spleen weight, total leukocytes, and lymphocytes decreased during SR for 21 days when compared with the control group, although production of a certain class of immunoglobulin, the IgM, did increase. After recovery sleep, lymphocyte count in axillary lymph nodes grew when rats had rebound sleep after PSD for 24 h, neutrophils increased after PSD 96 h and lymphocytes numbers were higher after SR 21 days. Such alterations during sleep deprivation suggest only minor alterations of nonspecific immune parameters during acute PSD, and a significant impairment in cellular response during chronic SR. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-07-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:48:49Z |
dc.date.available.fl_str_mv |
2016-01-24T13:48:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 293, n. 1, p. R504-R509, 2007. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/29834 https://dx.doi.org/10.1152/ajpregu.00105.2007 |
dc.identifier.issn.none.fl_str_mv |
0363-6119 |
dc.identifier.doi.none.fl_str_mv |
10.1152/ajpregu.00105.2007 |
dc.identifier.wos.none.fl_str_mv |
WOS:000247970700058 |
identifier_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 293, n. 1, p. R504-R509, 2007. 0363-6119 10.1152/ajpregu.00105.2007 WOS:000247970700058 |
url |
https://repositorio.unifesp.br/handle/11600/29834 https://dx.doi.org/10.1152/ajpregu.00105.2007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
R504-R509 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764135886225408 |