Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys

Detalhes bibliográficos
Autor(a) principal: Berro, Lais F. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Diaz, Maylen Perez, Maltbie, Eric, Howell, Leonard L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1007/s00213-017-4653-2
http://repositorio.unifesp.br/handle/11600/51363
Resumo: Accumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse. The aim of the present study was to evaluate the effects of the selective serotonin 5-HT2C receptor agonist WAY163909 on the behavioral neuropharmacology of cocaine and methamphetamine in adult rhesus macaques. Cocaine or methamphetamine self-administration and reinstatement were evaluated under second-order and fixed-ratio schedules of reinforcement, respectively. Cocaine- and methamphetamine-induced increases in dopamine were assessed through in vivo microdialysis targeting the nucleus accumbens. Pretreatment with WAY163909 dose-dependently attenuated cocaine and methamphetamine self-administration and drug-induced reinstatement of extinguished behavior previously maintained by cocaine or methamphetamine delivery. In an additional experiment, WAY163909 induced a dose-dependent attenuation of cocaine- or methamphetamine-induced dopamine overflow in the nucleus accumbens. Our data indicate that selective 5-HT2C receptor activation decreases drug intake and drug-seeking behavior in nonhuman primate models of psychostimulant abuse through neurochemical mechanisms involved in the modulation of mesolimbic dopamine.
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spelling Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeysCocaineMethamphetamineSelf-administrationReinstatementIn vivo microdialysisRhesus monkeysAccumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse. The aim of the present study was to evaluate the effects of the selective serotonin 5-HT2C receptor agonist WAY163909 on the behavioral neuropharmacology of cocaine and methamphetamine in adult rhesus macaques. Cocaine or methamphetamine self-administration and reinstatement were evaluated under second-order and fixed-ratio schedules of reinforcement, respectively. Cocaine- and methamphetamine-induced increases in dopamine were assessed through in vivo microdialysis targeting the nucleus accumbens. Pretreatment with WAY163909 dose-dependently attenuated cocaine and methamphetamine self-administration and drug-induced reinstatement of extinguished behavior previously maintained by cocaine or methamphetamine delivery. In an additional experiment, WAY163909 induced a dose-dependent attenuation of cocaine- or methamphetamine-induced dopamine overflow in the nucleus accumbens. Our data indicate that selective 5-HT2C receptor activation decreases drug intake and drug-seeking behavior in nonhuman primate models of psychostimulant abuse through neurochemical mechanisms involved in the modulation of mesolimbic dopamine.Emory Univ, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USAUniv Fed São Paulo, Dept Psychobiol, São Paulo, SP, BrazilEmory Univ, Dept Psychiat & Behav Sci, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USAUniv Fed São Paulo, Dept Psychobiol, São Paulo, SP, BrazilWeb of ScienceUSPHSAFIPFAPESPUSPHS: DA10344USPHS: DA031246USPHS: ODP51OD11132FAPESP: 2015/16109-7FAPESP: 2015/25482-3Springer2019-08-19T11:49:38Z2019-08-19T11:49:38Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2607-2617http://dx.doi.org/10.1007/s00213-017-4653-2Psychopharmacology. New York, v. 234, n. 17, p. 2607-2617, 2017.10.1007/s00213-017-4653-20033-3158http://repositorio.unifesp.br/handle/11600/51363WOS:000407397200008enginfo:eu-repo/semantics/openAccessBerro, Lais F. [UNIFESP]Diaz, Maylen PerezMaltbie, EricHowell, Leonard L.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T21:33:38Zoai:repositorio.unifesp.br/:11600/51363Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-10-05T21:33:38Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
title Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
spellingShingle Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
Berro, Lais F. [UNIFESP]
Cocaine
Methamphetamine
Self-administration
Reinstatement
In vivo microdialysis
Rhesus monkeys
title_short Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
title_full Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
title_fullStr Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
title_full_unstemmed Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
title_sort Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys
author Berro, Lais F. [UNIFESP]
author_facet Berro, Lais F. [UNIFESP]
Diaz, Maylen Perez
Maltbie, Eric
Howell, Leonard L.
author_role author
author2 Diaz, Maylen Perez
Maltbie, Eric
Howell, Leonard L.
author2_role author
author
author
dc.contributor.author.fl_str_mv Berro, Lais F. [UNIFESP]
Diaz, Maylen Perez
Maltbie, Eric
Howell, Leonard L.
dc.subject.por.fl_str_mv Cocaine
Methamphetamine
Self-administration
Reinstatement
In vivo microdialysis
Rhesus monkeys
topic Cocaine
Methamphetamine
Self-administration
Reinstatement
In vivo microdialysis
Rhesus monkeys
description Accumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse. The aim of the present study was to evaluate the effects of the selective serotonin 5-HT2C receptor agonist WAY163909 on the behavioral neuropharmacology of cocaine and methamphetamine in adult rhesus macaques. Cocaine or methamphetamine self-administration and reinstatement were evaluated under second-order and fixed-ratio schedules of reinforcement, respectively. Cocaine- and methamphetamine-induced increases in dopamine were assessed through in vivo microdialysis targeting the nucleus accumbens. Pretreatment with WAY163909 dose-dependently attenuated cocaine and methamphetamine self-administration and drug-induced reinstatement of extinguished behavior previously maintained by cocaine or methamphetamine delivery. In an additional experiment, WAY163909 induced a dose-dependent attenuation of cocaine- or methamphetamine-induced dopamine overflow in the nucleus accumbens. Our data indicate that selective 5-HT2C receptor activation decreases drug intake and drug-seeking behavior in nonhuman primate models of psychostimulant abuse through neurochemical mechanisms involved in the modulation of mesolimbic dopamine.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019-08-19T11:49:38Z
2019-08-19T11:49:38Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00213-017-4653-2
Psychopharmacology. New York, v. 234, n. 17, p. 2607-2617, 2017.
10.1007/s00213-017-4653-2
0033-3158
http://repositorio.unifesp.br/handle/11600/51363
WOS:000407397200008
url http://dx.doi.org/10.1007/s00213-017-4653-2
http://repositorio.unifesp.br/handle/11600/51363
identifier_str_mv Psychopharmacology. New York, v. 234, n. 17, p. 2607-2617, 2017.
10.1007/s00213-017-4653-2
0033-3158
WOS:000407397200008
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2607-2617
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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