Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma

Detalhes bibliográficos
Autor(a) principal: Siviero-Miachon, Adriana Aparecida [UNIFESP]
Data de Publicação: 2011
Outros Autores: Monteiro, Carlos Manoel de Castro [UNIFESP], Pires, Liliane Viana, Rozalem, Ana Carolina [UNIFESP], Silva, Nasjla Saba da [UNIFESP], Petrilli, Antonio Sergio [UNIFESP], Spinola-Castro, Angela Maria [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302011000800022
http://repositorio.unifesp.br/handle/11600/6689
Resumo: OBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.
id UFSP_67c7a35354cdaeeeecd4f203de54072e
oai_identifier_str oai:repositorio.unifesp.br/:11600/6689
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastomaFatores precoces para síndrome metabólica em sobreviventes de câncer pediátrico: resultados em adolescentes e adultos jovens tratados por meduloblastoma na infânciaMedulloblastomamedulloblastomacardiovascular diseasesmetabolic syndrome XMeduloblastomameduloblastomaprevenção e controledoenças cardiovascularessíndrome X metabólicaOBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.OBJETIVO: Analisar características que predispõem para síndrome metabólica (SM) em sobreviventes de meduloblastoma. SUJEITOS E MÉTODOS: Dezesseis sobreviventes de meduloblastoma pediátrico, 18,0 (4,4) anos, história de radioterapia (RT) cranioespinhal, comparados a nove controles pareados por idade, sexo e índice de massa corporal, de acordo com distribuição de gordura, variáveis metabólicas e cardiovasculares. RESULTADOS: Pacientes com meduloblastoma mostraram aumento da cintura e relações (todos p < 0,05) e HOMA1-IR (p = 0,006), modificados pela secreção do hormônio de crescimento (GH), mas dentro dos limites de normalidade. CONCLUSÕES: Sobreviventes adolescentes e adultos jovens de meduloblastoma apresentaram deposição centrípeta de gordura e diminuição da sensibilidade à insulina, associados ao estado do GH. Sobreviventes de tumor cerebral pediátrico que receberam RT devem ser monitorados para diagnosticar fatores para SM predispondo à doença cardiovascular.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Department of PediatricsUNIFESP-EPM Department of MedicineUniversidade de São Paulo Department of Food Science and Experimental Nutrition Pharmaceutical Science SchoolUNIFESP-EPM Department of PediatricsUNIFESP, EPM, Department of PediatricsUNIFESP, EPM Department of MedicineUNIFESP, EPM Department of PediatricsSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sociedade Brasileira de Endocrinologia e MetabologiaUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Siviero-Miachon, Adriana Aparecida [UNIFESP]Monteiro, Carlos Manoel de Castro [UNIFESP]Pires, Liliane VianaRozalem, Ana Carolina [UNIFESP]Silva, Nasjla Saba da [UNIFESP]Petrilli, Antonio Sergio [UNIFESP]Spinola-Castro, Angela Maria [UNIFESP]2015-06-14T13:43:20Z2015-06-14T13:43:20Z2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion653-660application/pdfhttp://dx.doi.org/10.1590/S0004-27302011000800022Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 8, p. 653-660, 2011.10.1590/S0004-27302011000800022S0004-27302011000800022.pdf0004-2730S0004-27302011000800022http://repositorio.unifesp.br/handle/11600/6689WOS:000298885900022engArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T10:02:31Zoai:repositorio.unifesp.br/:11600/6689Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T10:02:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
Fatores precoces para síndrome metabólica em sobreviventes de câncer pediátrico: resultados em adolescentes e adultos jovens tratados por meduloblastoma na infância
title Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
spellingShingle Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
Siviero-Miachon, Adriana Aparecida [UNIFESP]
Medulloblastoma
medulloblastoma
cardiovascular diseases
metabolic syndrome X
Meduloblastoma
meduloblastoma
prevenção e controle
doenças cardiovasculares
síndrome X metabólica
title_short Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_full Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_fullStr Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_full_unstemmed Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
title_sort Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma
author Siviero-Miachon, Adriana Aparecida [UNIFESP]
author_facet Siviero-Miachon, Adriana Aparecida [UNIFESP]
Monteiro, Carlos Manoel de Castro [UNIFESP]
Pires, Liliane Viana
Rozalem, Ana Carolina [UNIFESP]
Silva, Nasjla Saba da [UNIFESP]
Petrilli, Antonio Sergio [UNIFESP]
Spinola-Castro, Angela Maria [UNIFESP]
author_role author
author2 Monteiro, Carlos Manoel de Castro [UNIFESP]
Pires, Liliane Viana
Rozalem, Ana Carolina [UNIFESP]
Silva, Nasjla Saba da [UNIFESP]
Petrilli, Antonio Sergio [UNIFESP]
Spinola-Castro, Angela Maria [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Siviero-Miachon, Adriana Aparecida [UNIFESP]
Monteiro, Carlos Manoel de Castro [UNIFESP]
Pires, Liliane Viana
Rozalem, Ana Carolina [UNIFESP]
Silva, Nasjla Saba da [UNIFESP]
Petrilli, Antonio Sergio [UNIFESP]
Spinola-Castro, Angela Maria [UNIFESP]
dc.subject.por.fl_str_mv Medulloblastoma
medulloblastoma
cardiovascular diseases
metabolic syndrome X
Meduloblastoma
meduloblastoma
prevenção e controle
doenças cardiovasculares
síndrome X metabólica
topic Medulloblastoma
medulloblastoma
cardiovascular diseases
metabolic syndrome X
Meduloblastoma
meduloblastoma
prevenção e controle
doenças cardiovasculares
síndrome X metabólica
description OBJECTIVE: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. SUBJECTS AND METHODS: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. RESULTS: Medulloblastoma patients showed increases in waist circum-ference and its relationships (all p < 0.05), and HOMA1-IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. CONCLUSIONS: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
2015-06-14T13:43:20Z
2015-06-14T13:43:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302011000800022
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 8, p. 653-660, 2011.
10.1590/S0004-27302011000800022
S0004-27302011000800022.pdf
0004-2730
S0004-27302011000800022
http://repositorio.unifesp.br/handle/11600/6689
WOS:000298885900022
url http://dx.doi.org/10.1590/S0004-27302011000800022
http://repositorio.unifesp.br/handle/11600/6689
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 55, n. 8, p. 653-660, 2011.
10.1590/S0004-27302011000800022
S0004-27302011000800022.pdf
0004-2730
S0004-27302011000800022
WOS:000298885900022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 653-660
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268445857939456

Registros relacionados