Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6739 http://dx.doi.org/10.1590/S0074-02762011000800006 |
Resumo: | The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. |
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Machado, Daisy Maria [UNIFESP]Fink, Maria CristinaPannuti, Cláudio SérgioSucci, Regina Célia de Menezes [UNIFESP]Machado, Alessandra AparecidaCarmo, Fabiana Bononi do [UNIFESP]Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]Urbano, Paulo RobertoBeltrão, Suênia Vasconcelos [UNIFESP]Santos, Isabel Cristina Lopes dos [UNIFESP]Machado, Clarisse Martins [UNIFESP]Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:43:23Z2015-06-14T13:43:23Z2011-12-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 931-935, 2011.0074-0276http://repositorio.unifesp.br/handle/11600/6739http://dx.doi.org/10.1590/S0074-02762011000800006S0074-02762011000800006.pdfS0074-0276201100080000610.1590/S0074-02762011000800006WOS:000299068800006The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.Universidade de São Paulo Instituto de Medicina Tropical de São Paulo Laboratório de VirologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de PediatriaUNIFESP, Depto. de PediatriaSciELO931-935engInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo CruzHIV-1childadolescentJC virusBK virusurineHuman polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0074-02762011000800006.pdfapplication/pdf455318${dspace.ui.url}/bitstream/11600/6739/1/S0074-02762011000800006.pdf92f8a1d4ba50230eabe4ca2c4a6cabbaMD51open accessTEXTS0074-02762011000800006.pdf.txtS0074-02762011000800006.pdf.txtExtracted texttext/plain22573${dspace.ui.url}/bitstream/11600/6739/21/S0074-02762011000800006.pdf.txt2f09922bca6d732ac84f8117f8d21591MD521open accessTHUMBNAILS0074-02762011000800006.pdf.jpgS0074-02762011000800006.pdf.jpgIM Thumbnailimage/jpeg6941${dspace.ui.url}/bitstream/11600/6739/23/S0074-02762011000800006.pdf.jpg54bd9a5d311912644f22c646f04f1132MD523open access11600/67392023-06-05 19:28:21.297open accessoai:repositorio.unifesp.br:11600/6739Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:28:21Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
title |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
spellingShingle |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV Machado, Daisy Maria [UNIFESP] HIV-1 child adolescent JC virus BK virus urine |
title_short |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
title_full |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
title_fullStr |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
title_full_unstemmed |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
title_sort |
Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
author |
Machado, Daisy Maria [UNIFESP] |
author_facet |
Machado, Daisy Maria [UNIFESP] Fink, Maria Cristina Pannuti, Cláudio Sérgio Succi, Regina Célia de Menezes [UNIFESP] Machado, Alessandra Aparecida Carmo, Fabiana Bononi do [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Urbano, Paulo Roberto Beltrão, Suênia Vasconcelos [UNIFESP] Santos, Isabel Cristina Lopes dos [UNIFESP] Machado, Clarisse Martins [UNIFESP] |
author_role |
author |
author2 |
Fink, Maria Cristina Pannuti, Cláudio Sérgio Succi, Regina Célia de Menezes [UNIFESP] Machado, Alessandra Aparecida Carmo, Fabiana Bononi do [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Urbano, Paulo Roberto Beltrão, Suênia Vasconcelos [UNIFESP] Santos, Isabel Cristina Lopes dos [UNIFESP] Machado, Clarisse Martins [UNIFESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Machado, Daisy Maria [UNIFESP] Fink, Maria Cristina Pannuti, Cláudio Sérgio Succi, Regina Célia de Menezes [UNIFESP] Machado, Alessandra Aparecida Carmo, Fabiana Bononi do [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Urbano, Paulo Roberto Beltrão, Suênia Vasconcelos [UNIFESP] Santos, Isabel Cristina Lopes dos [UNIFESP] Machado, Clarisse Martins [UNIFESP] |
dc.subject.eng.fl_str_mv |
HIV-1 child adolescent JC virus BK virus urine |
topic |
HIV-1 child adolescent JC virus BK virus urine |
description |
The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-12-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:43:23Z |
dc.date.available.fl_str_mv |
2015-06-14T13:43:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 931-935, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6739 http://dx.doi.org/10.1590/S0074-02762011000800006 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
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S0074-02762011000800006.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0074-02762011000800006 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762011000800006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000299068800006 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 931-935, 2011. 0074-0276 S0074-02762011000800006.pdf S0074-02762011000800006 10.1590/S0074-02762011000800006 WOS:000299068800006 |
url |
http://repositorio.unifesp.br/handle/11600/6739 http://dx.doi.org/10.1590/S0074-02762011000800006 |
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eng |
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Memórias do Instituto Oswaldo Cruz |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
931-935 |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Repositório Institucional da UNIFESP |
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